KEGG   Homo sapiens (human): 115004
Entry
115004            CDS       T01001                                 
Symbol
CGAS, C6orf150, D4, MB21D1, h-cGAS
Name
(RefSeq) cyclic GMP-AMP synthase
  KO
K17834  cyclic GMP-AMP synthase [EC:2.7.7.86]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05131  Shigellosis
hsa05163  Human cytomegalovirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06182  Shigella
nt06520  CGAS-STING signaling
  Element
N00395  cGAS-STING signaling pathway
N00569  HSV UL41 to cGAS-STING signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    115004 (CGAS)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    115004 (CGAS)
   05171 Coronavirus disease - COVID-19
    115004 (CGAS)
   05168 Herpes simplex virus 1 infection
    115004 (CGAS)
   05163 Human cytomegalovirus infection
    115004 (CGAS)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    115004 (CGAS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.86  cyclic GMP-AMP synthase
     115004 (CGAS)
SSDB
Motif
Pfam: Mab-21 Mab-21_C SLD3
Other DBs
NCBI-GeneID: 115004
NCBI-ProteinID: NP_612450
OMIM: 613973
HGNC: 21367
Ensembl: ENSG00000164430
UniProt: Q8N884
Structure
Position
6:complement(73423711..73452297)
AA seq 522 aa
MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
NT seq 1569 nt   +upstreamnt  +downstreamnt
atgcagccttggcacggaaaggccatgcagagagcttccgaggccggagccactgccccc
aaggcttccgcacggaatgccaggggcgccccgatggatcccaccgagtctccggctgcc
cccgaggccgccctgcctaaggcgggaaagttcggccccgccaggaagtcgggatcccgg
cagaaaaagagcgccccggacacccaggagaggccgcccgtccgcgcaactggggcccgc
gccaaaaaggcccctcagcgcgcccaggacacgcagccgtctgacgccaccagcgcccct
ggggcagaggggctggagcctcctgcggctcgggagccggctctttccagggctggttct
tgccgccagaggggcgcgcgctgctccacgaagccaagacctccgcccgggccctgggac
gtgcccagccccggcctgccggtctcggcccccattctcgtacggagggatgcggcgcct
ggggcctcgaagctccgggcggttttggagaagttgaagctcagccgcgatgatatctcc
acggcggcggggatggtgaaaggggttgtggaccacctgctgctcagactgaagtgcgac
tccgcgttcagaggcgtcgggctgctgaacaccgggagctactatgagcacgtgaagatt
tctgcacctaatgaatttgatgtcatgtttaaactggaagtccccagaattcaactagaa
gaatattccaacactcgtgcatattactttgtgaaatttaaaagaaatccgaaagaaaat
cctctgagtcagtttttagaaggtgaaatattatcagcttctaagatgctgtcaaagttt
aggaaaatcattaaggaagaaattaacgacattaaagatacagatgtcatcatgaagagg
aaaagaggagggagccctgctgtaacacttcttattagtgaaaaaatatctgtggatata
accctggctttggaatcaaaaagtagctggcctgctagcacccaagaaggcctgcgcatt
caaaactggctttcagcaaaagttaggaagcaactacgactaaagccattttaccttgta
cccaagcatgcaaaggaaggaaatggtttccaagaagaaacatggcggctatccttctct
cacatcgaaaaggaaattttgaacaatcatggaaaatctaaaacgtgctgtgaaaacaaa
gaagagaaatgttgcaggaaagattgtttaaaactaatgaaataccttttagaacagctg
aaagaaaggtttaaagacaaaaaacatctggataaattctcttcttatcatgtgaaaact
gccttctttcacgtatgtacccagaaccctcaagacagtcagtgggaccgcaaagacctg
ggcctctgctttgataactgcgtgacatactttcttcagtgcctcaggacagaaaaactt
gagaattattttattcctgaattcaatctattctctagcaacttaattgacaaaagaagt
aaggaatttctgacaaagcaaattgaatatgaaagaaacaatgagtttccagtttttgat
gaattttga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Network (7)   
   KEGG NETWORK (7)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
3D Structure (40)   
   PDB (40)   
Protein domain (3)   
   Pfam (3)   
All databases (110)   

Download RDF
DBGET integrated database retrieval system