KEGG   Homo sapiens (human): 1179
Entry
1179              CDS       T01001                                 
Symbol
CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hCLCA1, hCaCC-1
Name
(RefSeq) chloride channel accessory 1
  KO
K05027  calcium-activated chloride channel regulator 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04924  Renin secretion
hsa04972  Pancreatic secretion
Drug target
Crofelemer: D03605<US>
Niflumic acid: D08275
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    1179 (CLCA1)
  09154 Digestive system
   04972 Pancreatic secretion
    1179 (CLCA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1179 (CLCA1)
Ion channels [BR:hsa04040]
 Chloride channels
  Chloride channel, calcium-activated (CaCC)
   1179 (CLCA1)
SSDB
Motif
Pfam: CLCA VWA_2 VWA VWA_CoxE Cas_Cas1
Other DBs
NCBI-GeneID: 1179
NCBI-ProteinID: NP_001276
OMIM: 603906
HGNC: 2015
Ensembl: ENSG00000016490
UniProt: A8K7I4
Structure
Position
1:86468927..86500259
AA seq 914 aa
MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQA
SLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTE
QMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNG
RIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFA
QHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLL
QIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELI
QINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISG
CFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNG
AVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQG
GFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKD
TSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSR
YFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDD
VQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDY
DHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDL
FIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILK
IMWKWIGELQLSIA
NT seq 2745 nt   +upstreamnt  +downstreamnt
atggggccatttaagagttctgtgttcatcttgattcttcaccttctagaaggggccctg
agtaattcactcattcagctgaacaacaatggctatgaaggcattgtcgttgcaatcgac
cccaatgtgccagaagatgaaacactcattcaacaaataaaggacatggtgacccaggca
tctctgtatctgcttgaagctacaggaaagcgattttatttcaaaaatgttgccattttg
attcctgaaacatggaagacaaaggctgactatgtgagaccaaaacttgagacctacaaa
aatgctgatgttctggttgctgagtctactcctccaggtaatgatgaaccctacactgag
cagatgggcaactgtggagagaagggtgaaaggatccacctcactcctgatttcattgca
ggaaaaaagttagctgaatatggaccacaaggtagggcatttgtccatgagtgggctcat
ctacgatggggagtatttgacgagtacaataatgatgagaaattctacttatccaatgga
agaatacaagcagtaagatgttcagcaggtattactggtacaaatgtagtaaagaagtgt
cagggaggcagctgttacaccaaaagatgcacattcaataaagtaacaggactctatgaa
aaaggatgtgagtttgttctccaatcccgccagacggagaaggcttctataatgtttgca
caacatgttgattctatagttgaattctgtacagaacaaaaccacaacaaagaagctcca
aacaagcaaaatcaaaaatgcaatctccgaagcacatgggaagtgatccgtgattctgag
gactttaagaaaaccactcctatgacaacacagccaccaaatcccaccttctcattgctg
cagattggacaaagaattgtgtgtttagtccttgacaaatctggaagcatggcgactggt
aaccgcctcaatcgactgaatcaagcaggccagcttttcctgctgcagacagttgagctg
gggtcctgggttgggatggtgacatttgacagtgctgcccatgtacaaaatgaactcata
cagataaacagtggcagtgacagggacacactcgccaaaagattacctgcagcagcttca
ggagggacgtccatctgcagcgggcttcgatcggcatttactgtgattaggaagaaatat
ccaactgatggatctgaaattgtgctgctgacggatggggaagacaacactataagtggg
tgctttaacgaggtcaaacaaagtggtgccatcatccacacagtcgctttggggccctct
gcagctcaagaactagaggagctgtccaaaatgacaggaggtttacagacatatgcttca
gatcaagttcagaacaatggcctcattgatgcttttggggccctttcatcaggaaatgga
gctgtctctcagcgctccatccagcttgagagtaagggattaaccctccagaacagccag
tggatgaatggcacagtgatcgtggacagcaccgtgggaaaggacactttgtttcttatc
acctggacaatgcagcctccccaaatccttctctgggatcccagtggacagaagcaaggt
ggctttgtagtggacaaaaacaccaaaatggcctacctccaaatcccaggcattgctaag
gttggcacttggaaatacagtctgcaagcaagctcacaaaccttgaccctgactgtcacg
tcccgtgcgtccaatgctaccctgcctccaattacagtgacttccaaaacgaacaaggac
accagcaaattccccagccctctggtagtttatgcaaatattcgccaaggagcctcccca
attctcagggccagtgtcacagccctgattgaatcagtgaatggaaaaacagttaccttg
gaactactggataatggagcaggtgctgatgctactaaggatgacggtgtctactcaagg
tatttcacaacttatgacacgaatggtagatacagtgtaaaagtgcgggctctgggagga
gttaacgcagccagacggagagtgataccccagcagagtggagcactgtacatacctggc
tggattgagaatgatgaaatacaatggaatccaccaagacctgaaattaataaggatgat
gttcaacacaagcaagtgtgtttcagcagaacatcctcgggaggctcatttgtggcttct
gatgtcccaaatgctcccatacctgatctcttcccacctggccaaatcaccgacctgaag
gcggaaattcacgggggcagtctcattaatctgacttggacagctcctggggatgattat
gaccatggaacagctcacaagtatatcattcgaataagtacaagtattcttgatctcaga
gacaagttcaatgaatctcttcaagtgaatactactgctctcatcccaaaggaagccaac
tctgaggaagtctttttgtttaaaccagaaaacattacttttgaaaatggcacagatctt
ttcattgctattcaggctgttgataaggtcgatctgaaatcagaaatatccaacattgca
cgagtatctttgtttattcctccacagactccgccagagacacctagtcctgatgaaacg
tctgctccttgtcctaatattcatatcaacagcaccattcctggcattcacattttaaaa
attatgtggaagtggataggagaactgcagctgtcaatagcctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   Pfam (5)   
All databases (57)   

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