KEGG   Homo sapiens (human): 1181
Entry
1181              CDS       T01001                                 
Symbol
CLCN2, CIC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, FHA2, FHII, HALD2, LKPAT, clC-2
Name
(RefSeq) chloride voltage-gated channel 2
  KO
K05011  chloride channel 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04978  Mineral absorption
Disease
H00808  Idiopathic generalized epilepsies
H02216  Juvenile absence epilepsy
H02217  Juvenile myoclonic epilepsy
Drug target
Lubiprostone: D04790<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    1181 (CLCN2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1181 (CLCN2)
Ion channels [BR:hsa04040]
 Chloride channels
  Chloride channel (CLC)
   1181 (CLCN2)
SSDB
Motif
Pfam: Voltage_CLC CBS Toprim
Other DBs
NCBI-GeneID: 1181
NCBI-ProteinID: NP_004357
OMIM: 600570
HGNC: 2020
Ensembl: ENSG00000114859
UniProt: P51788
Structure
Position
3:complement(184346185..184361605)
AA seq 898 aa
MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPE
LLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQ
WMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYL
TLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEML
AAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEE
TITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLM
RKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPST
SQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAW
FPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVIL
ANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDL
RLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPL
SDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESA
GIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLD
EPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE
GSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ
NT seq 2697 nt   +upstreamnt  +downstreamnt
atggcggccgcggcggcggaggaagggatggagccacgggcgctgcagtacgagcagacc
ctgatgtatggccggtacactcaggaccttggggcctttgccaaagaggaagctgctcgg
attcgcctgggagggcctgaaccctggaaaggtcccccttcctctcgggctgccccagag
ctcttggaatatggacggagccgttgcgcccgatgccgcgtctgttctgtccgctgccac
aagttcctagtatccagggttggtgaagattggatcttcctggtcctgctggggcttctc
atggcattggtcagctgggtcatggactatgccattgctgcctgtctgcaagcccagcag
tggatgtcccggggcttgaacaccagcatcttgctccagtacctggcctgggtcacctac
cctgttgtcctcatcactttctcagccggattcacacagatcctggcccctcaggctgtc
ggctctggcatccctgagatgaagaccatcttgcggggagtggtgctgaaagaatacctc
acactcaagacctttatagctaaggtcattgggctgacctgcgccctaggcagcgggatg
ccgcttggcaaagagggcccttttgtgcatatcgcaagcatgtgtgctgcccttctcagc
aagttcctctccctctttgggggtatctatgagaatgaatcccggaacacagagatgctg
gctgccgcctgtgccgtgggggtgggctgctgcttcgcggcacctattggaggcgtcctc
ttcagcatcgaggtcacctccaccttctttgcagtgcggaactactggcggggcttcttc
gctgccaccttcagtgccttcatcttccgggtcttggcagtctggaaccgggatgaagag
actattacagccctcttcaaaacccgattccggctcgacttcccctttgacctgcaggag
ctgccagcctttgctgtcattggtattgctagtggcttcggtggagccctctttgtctac
ctgaaccggaagattgtccaggtgatgcggaagcagaaaaccatcaatcgcttcctcatg
aggaaacgcctgctcttcccggctctggtgaccctgctcatctccacgctgaccttcccc
cctggctttggacagttcatggctggacagctctcacagaaagagacgctggtcaccctg
tttgacaatcggacgtgggtccgccagggcctggtggaggagctagaaccacccagcacc
tcacaggcctggaacccaccacgtgccaacgtcttcctcaccctggtcatcttcattctc
atgaagttctggatgtctgcactggccaccaccatcccagttccctgtggggccttcatg
cctgtctttgtcattggagcagcatttgggcgtctggtgggtgaaagcatggctgcctgg
ttcccagatggaattcatacggacagcagcacctaccggattgtgcctgggggctacgct
gtggtcggggcagctgcgctggcaggagcggtgacacacacagtgtccacggctgtgatc
gtgttcgagctcacaggccagattgcccacatcctgcctgtcatgatcgccgtcatcctg
gccaacgctgtcgcccagagtctgcagccctccctctatgacagcatcatccgaatcaag
aaactgccctacctgcctgagctcggctggggccgccaccagcagtaccgggtgcgtgtg
gaggacatcatggtgcgggatgttccccatgtggccctcagctgcaccttccgggacctg
cgtttggcactgcacaggaccaagggccgaatgctggccctagtggagtcccctgagtcc
atgattctgctgggctccatcgagcgttcacaggtggtggcattgttgggggcccagctg
agcccagcccgccggcggcagcacatgcaggagcgcagagccacccagacctctccacta
tctgatcaggagggtccccctacccctgaggcttctgtctgcttccaggtgaacacagaa
gactcagccttcccagcagcccggggggagacccacaagcccctaaagcctgcactcaag
agggggcccagtgtcaccaggaacctcggagagagtcccacagggagcgcagagtcggca
ggcatcgccctccggagcctcttctgtggcagtccaccccctgaggctgcttcggagaag
ttggaatcctgtgagaagcgcaagctgaagcgtgtccgaatctccctggcaagtgacgcg
gacctggaaggcgagatgagccctgaagagattctggagtgggaggagcagcaactagat
gaacctgtcaacttcagtgactgcaaaattgatcctgctcccttccagctggtggagcgg
acctctttgcacaagactcacactatcttctcactgctgggagtggaccatgcttatgtc
accagtattggcagactcattggaatcgttactctaaaggagctccggaaggccatcgag
ggctctgtcacagcacagggtgtgaaagtccggccgcccctcgccagcttccgagacagt
gccaccagcagcagtgacacggagaccactgaggtgcatgcactctgggggccccactcc
cgtcatggcctcccccgggagggcagcccttccgacagcgacgacaaatgccaatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (42)   
   RefSeq(nuc) (10)   
   GenBank (16)   
   EMBL (16)   
3D Structure (3)   
   PDB (3)   
Protein domain (3)   
   Pfam (3)   
All databases (86)   

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