KEGG   Homo sapiens (human): 123099
Entry
123099            CDS       T01001                                 
Symbol
DEGS2, C14orf66, DES2, FADS8
Name
(RefSeq) delta 4-desaturase, sphingolipid 2
  KO
K04712  sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00600  Sphingolipid metabolism
hsa01100  Metabolic pathways
hsa04071  Sphingolipid signaling pathway
Module
hsa_M00094  Ceramide biosynthesis
hsa_M00099  Sphingosine biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    123099 (DEGS2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    123099 (DEGS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins [BR:hsa01004]
    123099 (DEGS2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.5  sphingolipid C4-monooxygenase
     123099 (DEGS2)
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.17  sphingolipid 4-desaturase
     123099 (DEGS2)
Lipid biosynthesis proteins [BR:hsa01004]
 Desaturase
  Sphingolipid
   123099 (DEGS2)
SSDB
Motif
Pfam: FA_desaturase Lipid_DES
Other DBs
NCBI-GeneID: 123099
NCBI-ProteinID: NP_996801
OMIM: 610862
HGNC: 20113
Ensembl: ENSG00000168350
UniProt: Q6QHC5
Position
14:complement(100143957..100166886)
AA seq 323 aa
MGNSASRSDFEWVYTDQPHTQRRKEILAKYPAIKALMRPDPRLKWAVLVLVLVQMLACWL
VRGLAWRWLLFWAYAFGGCVNHSLTLAIHDISHNAAFGTGRAARNRWLAVFANLPVGVPY
AASFKKYHVDHHRYLGGDGLDVDVPTRLEGWFFCTPARKLLWLVLQPFFYSLRPLCVHPK
AVTRMEVLNTLVQLAADLAIFALWGLKPVVYLLASSFLGLGLHPISGHFVAEHYMFLKGH
ETYSYYGPLNWITFNVGYHVEHHDFPSIPGYNLPLVRKIAPEYYDHLPQHHSWVKVLWDF
VFEDSLGPYARVKRVYRLAKDGL
NT seq 972 nt   +upstreamnt  +downstreamnt
atgggcaacagcgcgagccgcagcgacttcgagtgggtctacaccgaccagccgcacacg
cagcggcgcaaggagatactggccaagtacccggccatcaaggccctgatgcggccagac
ccgcgcctcaagtgggcggtgctggtgctggtgctggtgcagatgctggcctgctggctg
gtgcgcgggctggcctggcgctggctgctgttctgggcctacgcctttggtggctgcgtg
aaccactcgctgacgctggccatccacgacatctcgcacaacgcggccttcggcacgggc
cgtgcggcacgcaaccgctggctggccgtgttcgccaacctgcccgtgggtgtgccctac
gccgcctccttcaagaagtaccacgtggaccaccaccgctacctgggcggcgacgggctg
gacgtggacgtgcccacgcgtctggagggctggttcttctgcacacccgcccgcaagctg
ctctggctggtgctgcagcccttcttctactcactacggccgctctgcgtccaccccaag
gccgtgacccgcatggaggtgctcaacacgctggtgcagctggcggccgacctggccatc
tttgccctttgggggctcaagcccgtggtctacctgctggccagctccttcctgggcctg
ggcctgcaccccatctcgggccacttcgtggccgagcactacatgttcctcaagggccac
gagacctactcctactatgggcctctcaactggatcaccttcaatgtgggctaccacgtg
gagcaccacgacttccccagcatcccgggctacaacctgccgctggtgcggaagatcgcg
cccgagtactacgaccacctgccgcagcaccactcctgggtgaaggtgctctgggatttt
gtgtttgaggactccctggggccctatgccagggtgaagcgggtgtacaggctggcaaaa
gatggtctgtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (2)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (11)   
   RefSeq(nuc) (3)   
   GenBank (4)   
   EMBL (4)   
Protein domain (2)   
   Pfam (2)   
All databases (64)   

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