KEGG   Homo sapiens (human): 126129
Entry
126129            CDS       T01001                                 
Symbol
CPT1C, CATL1, CPT_I-C, CPT1-B, CPT1P, CPTI-B, CPTIC, SPG73
Name
(RefSeq) carnitine palmitoyltransferase 1C
  KO
K19524  carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00071  Fatty acid degradation
hsa01212  Fatty acid metabolism
hsa03320  PPAR signaling pathway
hsa04148  Efferocytosis
hsa04152  AMPK signaling pathway
hsa04714  Thermogenesis
hsa04920  Adipocytokine signaling pathway
hsa04922  Glucagon signaling pathway
hsa04936  Alcoholic liver disease
Network
nt06020  beta-Oxidation in mitochondria
  Element
N00765  beta-Oxidation, acyl-CoA synthesis
Disease
H00266  Hereditary spastic paraplegia
Drug target
Oxfenicine: D05292
Perhexiline (DG00334): D05442 D08340
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    126129 (CPT1C)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    126129 (CPT1C)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    126129 (CPT1C)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    126129 (CPT1C)
   04920 Adipocytokine signaling pathway
    126129 (CPT1C)
   03320 PPAR signaling pathway
    126129 (CPT1C)
  09159 Environmental adaptation
   04714 Thermogenesis
    126129 (CPT1C)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    126129 (CPT1C)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    126129 (CPT1C)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.21  carnitine O-palmitoyltransferase
     126129 (CPT1C)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    126129 (CPT1C)
SSDB
Motif
Pfam: Carn_acyltransf CPT_N PaaA2
Other DBs
NCBI-GeneID: 126129
NCBI-ProteinID: NP_001186681
OMIM: 608846
HGNC: 18540
Ensembl: ENSG00000169169
UniProt: Q8TCG5 B3KU49
Structure
Position
19:49690662..49713731
AA seq 803 aa
MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPL
SWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLRGVLAAALFASCLWGALIF
TLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQ
DTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFV
YLRSRNPLMVNSNYYMMDFLYVTPTPLQAARAGNAVHALLLYRHRLNRQEIPPTLLMGMR
PLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHSRNSLLSPRALEQ
QFQRILDDPSPACPHEEHLAALTAAPRGTWAQVRTSLKTQAAEALEAVEGAAFFVSLDAE
PAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGH
MWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSEN
VDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTE
TVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIV
SRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVS
YIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENS
RHRCGFLSRQTGASKASMTSTDF
NT seq 2412 nt   +upstreamnt  +downstreamnt
atggctgaagcgcaccaggccgtgggcttccgaccctcgctgacctcggacggggctgaa
gtggaactcagtgcccctgtgctgcaggagatctacctctctggcctgcgctcctggaaa
aggcatctctcacgtttctggaatgactttctcaccggtgtgtttcctgccagccccctc
agttggcttttcctcttcagtgccatccagcttgcctggttcctccagctggatccttcc
ttaggactgatggagaagatcaaagagttgctgcctgactggggtggacaacaccacggg
ctccggggggtcctggcagccgcgctgtttgcctcgtgtttgtggggagccctgatcttc
acactgcacgtggccctgaggctgcttctgtcctaccacggctggcttcttgagccccac
ggagccatgtcctcccccaccaagacctggctggccctggtccgcatcttctctggccgc
cacccgatgctgttcagttaccagcgctccctgccacgccagcccgtgccctctgtgcag
gacaccgtgcgcaagtacctggagtcggtccggcccatcctctccgacgaggacttcgac
tggaccgcggtcctggcgcaggaattcctgaggctgcaggcgtcgctgctgcagtggtac
ctgcggctcaagtcctggtgggcgtccaattatgtcagtgactggtgggaggaatttgtg
tacctgcgctcccgaaatccgctgatggtgaacagcaactattacatgatggacttcctg
tatgtcacacccacgcctctgcaggcagctcgcgctgggaatgccgtccatgccctcctc
ctgtaccgccaccgcctgaaccgccaggagatacccccgactttgctgatgggaatgcgc
cccttatgctctgcccagtacgagaagatcttcaacaccacgcggattccaggggtccaa
aaagactacatccgccacctccatgacagccaacacgtggctgtcttccaccggggccga
ttcttccgcatggggacccactcccgaaacagcctgctttccccgagagccctggagcag
cagtttcagagaatcctggatgatccctcaccggcctgcccccacgaggaacatctggca
gctctgacagctgctcccaggggcacgtgggcccaggtgcggacatccctgaagacccag
gcagcggaggccctggaggcggtggaaggggccgctttctttgtgtcactggatgctgag
cccgcggggctcaccagggaggacccggcagcgtcgttggatgcctacgcccatgctctg
ctggccggccggggccatgatcgctggtttgacaaatccttcaccctaatcgtcttctct
aacgggaagctgggcctcagcgtggagcactcctgggccgactgccccatctcaggacac
atgtgggagttcactctggctacagaatgctttcagctgggctactcaacagacggccac
tgcaaggggcacccggaccccacactaccccagccccagcggctgcaatgggaccttcca
gaccagatccactcctccatctctctagccctgaggggagccaagatcttgtctgaaaat
gtcgactgccatgtcgttccattctccctatttggcaagagcttcatccgacgctgccac
ctctcttcagacagcttcatccagatcgccttgcaactggcccacttccgggacaggggt
caattctgcctgacttatgagtcggccatgactcgcttattcctggaaggccggacggag
acggtgcggtcttgcacgagggaggcctgcaactttgtcagggccatggaggacaaagag
aagacggacccacagtgcctcgccctgttccgcgtggcagtggacaagcaccaggctctg
ctgaaggcagccatgagcgggcagggagttgaccgccacctgtttgcgctgtacatcgtg
tcccgattcctccacctgcagtcgcccttcctgacccaggtccattcggagcagtggcag
ctgtccaccagccagatccctgttcagcaaatgcatctgtttgacgtccacaattacccg
gactatgtttcctcaggcggtggattcgggcctgctgatgaccatggttatggtgtttct
tatatcttcatgggggatggcatgatcaccttccacatctccagcaaaaaatcaagcaca
aaaacggattcccacaggctggggcagcacattgaggacgcactgctggatgtggcctcc
ctgttccaggcgggacagcattttaagcgccggttcagagggtcagggaaggagaactcc
aggcacaggtgtggatttctctcccgccagactggggcctccaaggcctcaatgacatcc
accgacttctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (9)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (38)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (35)   
DNA sequence (60)   
   RefSeq(nuc) (36)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (153)   

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