KEGG   Homo sapiens (human): 1352
Entry
1352              CDS       T01001                                 
Symbol
COX10, MC4DN3
Name
(RefSeq) cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
  KO
K02257  heme o synthase [EC:2.5.1.141]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa00860  Porphyrin metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04714  Thermogenesis
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06529  Thermogenesis
  Element
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01354  Leigh syndrome
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1352 (COX10)
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    1352 (COX10)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    1352 (COX10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    1352 (COX10)
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    1352 (COX10)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.141  heme o synthase
     1352 (COX10)
Prenyltransferases [BR:hsa01006]
 Compound prenylation
  Protoheme farnesyltransferase
   1352 (COX10)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial respiratory chain complex assembly factors
   Complex-IV assembly factors
    1352 (COX10)
SSDB
Motif
Pfam: UbiA
Other DBs
NCBI-GeneID: 1352
NCBI-ProteinID: NP_001294
OMIM: 602125
HGNC: 2260
Ensembl: ENSG00000006695
UniProt: Q12887
Position
17:14069504..14208677
AA seq 443 aa
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMY
VTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIE
LEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFA
TCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW
TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRH
CLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLP
LLLLLMLTCKRPSGGGDAGPPPS
NT seq 1332 nt   +upstreamnt  +downstreamnt
atggccgcatctccgcacactctctcctcacgcctcctgacaggttgcgtaggaggctct
gtctggtatcttgaaagaagaactatacaggactcccctcacaagttcttacatcttctc
aggaatgtcaataagcagtggattacatttcagcactttagcttcctcaaacgcatgtat
gtcacacagctgaacagaagccacaaccagcaagtaagacccaagccagaaccagtagca
tctcctttccttgaaaaaacatcttcaggtcaagccaaagcagaaatatatgagatgaga
cctctctcaccgcccagcctatctttgtccagaaagccaaatgaaaaggaattgatagaa
ctagagccagactcagtaattgaagactcaatagatgtagggaaagagacaaaagaggaa
aagcggtggaaagagatgaagctgcaagtgtatgatttgccaggaattttggctcgacta
tccaaaatcaaactcacagctctggttgtaagtaccactgcagctggatttgcattggct
ccgggcccttttgactggccctgtttcctgcttacttctgttgggacaggccttgcatcc
tgtgctgccaactccatcaatcagttttttgaggtgccatttgactcaaacatgaatagg
acaaagaacagaccgctggttcgtggacagatcagcccattgctagctgtgtcctttgcc
acttgttgtgctgttccgggagttgccattctgaccttgggggtgaatccactcacagga
gccctggggctcttcaacattttcctgtatacctgctgctacacaccactgaaaaggatc
agcattgccaacacatgggtcggagctgtggttggggccatcccgcctgtcatgggctgg
acagcggccacgggcagcctcgatgctggcgcatttctcctgggaggaatcctctactcc
tggcagtttcctcatttcaacgccctgagctggggcctccgtgaagactactcccggggc
ggctactgcatgatgtcggtcacccacccgggcctgtgccggcgcgtggcgctgcgccac
tgcctggccctgctcgtgctgtccgcagcagcccctgtgctggacatcaccacatggacc
ttccccatcatggcccttcccatcaatgcgtacatctcctacctcggcttccgcttctac
gtggacgcagaccgcaggagctcgcggagactgttcttctgcagcctgtggcacctgccg
ctgctgctgctgctcatgctcacctgcaagcggccgagcggaggcggggacgcagggccc
cctcccagctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
Protein domain (1)   
   Pfam (1)   
All databases (61)   

Download RDF
DBGET integrated database retrieval system