KEGG   Homo sapiens (human): 1395
Entry
1395              CDS       T01001                                 
Symbol
CRHR2, CRF-RB, CRF2, CRFR2, HM-CRF
Name
(RefSeq) corticotropin releasing hormone receptor 2
  KO
K04579  corticotropin releasing hormone receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04934  Cushing syndrome
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00324  CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
Drug target
Corticorelin (DG01167): D03591 D03592 D03905<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    1395 (CRHR2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1395 (CRHR2)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1395 (CRHR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1395 (CRHR2)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Hypothalamic hormone
   Corticotropin-releasing hormone (CRH)
    1395 (CRHR2)
SSDB
Motif
Pfam: 7tm_2 HRM
Other DBs
NCBI-GeneID: 1395
NCBI-ProteinID: NP_001874
OMIM: 602034
HGNC: 2358
Ensembl: ENSG00000106113
UniProt: Q13324 A0A090N7T4
Structure
Position
7:complement(30651942..30700103)
AA seq 411 aa
MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALV
ERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVN
YLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESN
EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIV
AWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
NT seq 1236 nt   +upstreamnt  +downstreamnt
atggacgcggcactgctccacagcctgctggaggccaactgcagcctggcgctggctgaa
gagctgctcttggacggctgggggccacccctggaccccgagggtccctactcctactgc
aacacgaccttggaccagatcggaacgtgctggccccgcagcgctgccggagccctcgtg
gagaggccgtgccccgagtacttcaacggcgtcaagtacaacacgacccggaatgcctat
cgagaatgcttggagaatgggacgtgggcctcaaagatcaactactcacagtgtgagccc
attttggatgacaagcagaggaagtatgacctgcactaccgcatcgcccttgtcgtcaac
tacctgggccactgcgtatctgtggcagccctggtggccgccttcctgcttttcctggcc
ctgcggagcattcgctgtctgcggaatgtgattcactggaacctcatcaccacctttatc
ctgcgaaatgtcatgtggttcctgctgcagctcgttgaccatgaagtgcacgagagcaat
gaggtctggtgccgctgcatcaccaccatcttcaactacttcgtggtgaccaacttcttc
tggatgtttgtggaaggctgctacctgcacacggccattgtcatgacctactccactgag
cgcctgcgcaagtgcctcttcctcttcatcggatggtgcatccccttccccatcatcgtc
gcctgggccatcggcaagctctactatgagaatgaacagtgctggtttggcaaggagcct
ggcgacctggtggactacatctaccaaggccccatcattctcgtgctcctgatcaatttc
gtatttctgttcaacatcgtcaggatcctaatgacaaagttacgcgcgtccaccacatcc
gagacaatccagtacaggaaggcagtgaaggccaccctggtgctcctgcccctcctgggc
atcacctacatgctcttcttcgtcaatcccggggaggacgacctgtcacagatcatgttc
atctatttcaactccttcctgcagtcgttccagggtttcttcgtgtctgtcttctactgc
ttcttcaatggagaggtgcgctcagccgtgaggaagaggtggcaccgctggcaggaccat
cactcccttcgagtccccatggcccgggccatgtccatccctacatcacccacacggatc
agcttccacagcatcaagcagacggccgctgtgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (53)   
   RefSeq(nuc) (9)   
   GenBank (22)   
   EMBL (22)   
3D Structure (6)   
   PDB (6)   
Protein domain (2)   
   Pfam (2)   
All databases (97)   

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