KEGG   Homo sapiens (human): 152831
Entry
152831            CDS       T01001                                 
Symbol
KLB, BKL
Name
(RefSeq) klotho beta
  KO
K22404  beta-klotho
Organism
hsa  Homo sapiens (human)
Pathway
hsa04714  Thermogenesis
Drug target
Fazpilodemab: D12490
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    152831 (KLB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    152831 (KLB)
Transporters [BR:hsa02000]
 Other transporters
  Accessory factors involved in transport [TC:8]
   152831 (KLB)
SSDB
Motif
Pfam: Glyco_hydro_1
Other DBs
NCBI-GeneID: 152831
NCBI-ProteinID: NP_783864
OMIM: 611135
HGNC: 15527
Ensembl: ENSG00000134962
UniProt: Q86Z14 B4DYH5
Structure
Position
4:39406930..39451533
AA seq 1044 aa
MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSALILLRAVTGFSGDGRAI
WSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKN
VSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLD
ALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIH
NPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITL
GSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEK
HEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWF
TDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFY
VDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVA
SSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFA
LDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADG
WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHA
LAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTG
DYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSR
YDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDD
RLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNK
VISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQ
KRRKFWKAKNLQHIPLKKGKRVVS
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgaagccaggctgtgcggcaggatctccagggaatgaatggattttcttcagcactgat
gaaataaccacacgctataggaatacaatgtccaacgggggattgcaaagatctgtcatc
ctgtcagcacttattctgctacgagctgttactggattctctggagatggaagagctata
tggtctaaaaatcctaattttactccggtaaatgaaagtcagctgtttctctatgacact
ttccctaaaaactttttctggggtattgggactggagcattgcaagtggaagggagttgg
aagaaggatggaaaaggaccttctatatgggatcatttcatccacacacaccttaaaaat
gtcagcagcacgaatggttccagtgacagttatatttttctggaaaaagacttatcagcc
ctggattttataggagtttctttttatcaattttcaatttcctggccaaggcttttcccc
gatggaatagtaacagttgccaacgcaaaaggtctgcagtactacagtactcttctggac
gctctagtgcttagaaacattgaacctatagttactttataccactgggatttgcctttg
gcactacaagaaaaatatggggggtggaaaaatgataccataatagatatcttcaatgac
tatgccacatactgtttccagatgtttggggaccgtgtcaaatattggattacaattcac
aacccatatctagtggcttggcatgggtatgggacaggtatgcatgcccctggagagaag
ggaaatttagcagctgtctacactgtgggacacaacttgatcaaggctcactcgaaagtt
tggcataactacaacacacatttccgcccacatcagaagggttggttatcgatcacgttg
ggatctcattggatcgagccaaaccggtcggaaaacacgatggatatattcaaatgtcaa
caatccatggtttctgtgcttggatggtttgccaaccctatccatggggatggcgactat
ccagaggggatgagaaagaagttgttctccgttctacccattttctctgaagcagagaag
catgagatgagaggcacagctgatttctttgccttttcttttggacccaacaacttcaag
cccctaaacaccatggctaaaatgggacaaaatgtttcacttaatttaagagaagcgctg
aactggattaaactggaatacaacaaccctcgaatcttgattgctgagaatggctggttc
acagacagtcgtgtgaaaacagaagacaccacggccatctacatgatgaagaatttcctc
agccaggtgcttcaagcaataaggttagatgaaatacgagtgtttggttatactgcctgg
tctctcctggatggctttgaatggcaggatgcttacaccatccgccgaggattattttat
gtggattttaacagtaaacagaaagagcggaaacctaagtcttcagcacactactacaaa
cagatcatacgagaaaatggtttttctttaaaagagtccacgccagatgtgcagggccag
tttccctgtgacttctcctggggtgtcactgaatctgttcttaagcccgagtctgtggct
tcgtccccacagttcagcgatcctcatctgtacgtgtggaacgccactggcaacagactg
ttgcaccgagtggaaggggtgaggctgaaaacacgacccgctcaatgcacagattttgta
aacatcaaaaaacaacttgagatgttggcaagaatgaaagtcacccactaccggtttgct
ctggattgggcctcggtccttcccactggcaacctgtccgcggtgaaccgacaggccctg
aggtactacaggtgcgtggtcagtgaggggctgaagcttggcatctccgcgatggtcacc
ctgtattatccgacccacgcccacctaggcctccccgagcctctgttgcatgccgacggg
tggctgaacccatcgacggccgaggccttccaggcctacgctgggctgtgcttccaggag
ctgggggacctggtgaagctctggatcaccatcaacgagcctaaccggctaagtgacatc
tacaaccgctctggcaacgacacctacggggcggcgcacaacctgctggtggcccacgcc
ctggcctggcgcctctacgaccggcagttcaggccctcacagcgcggggccgtgtcgctg
tcgctgcacgcggactgggcggaacccgccaacccctatgctgactcgcactggagggcg
gccgagcgcttcctgcagttcgagatcgcctggttcgccgagccgctcttcaagaccggg
gactaccccgcggccatgagggaatacattgcctccaagcaccgacgggggctttccagc
tcggccctgccgcgcctcaccgaggccgaaaggaggctgctcaagggcacggtcgacttc
tgcgcgctcaaccacttcaccactaggttcgtgatgcacgagcagctggccggcagccgc
tacgactcggacagggacatccagtttctgcaggacatcacccgcctgagctcccccacg
cgcctggctgtgattccctggggggtgcgcaagctgctgcggtgggtccggaggaactac
ggcgacatggacatttacatcaccgccagtggcatcgacgaccaggctctggaggatgac
cggctccggaagtactacctagggaagtaccttcaggaggtgctgaaagcatacctgatt
gataaagtcagaatcaaaggctattatgcattcaaactggctgaagagaaatctaaaccc
agatttggattcttcacatctgattttaaagctaaatcctcaatacaattttacaacaaa
gtgatcagcagcaggggcttcccttttgagaacagtagttctagatgcagtcagacccaa
gaaaatacagagtgcactgtctgcttattccttgtgcagaagaaaccactgatattcctg
ggttgttgcttcttctccaccctggttctactcttatcaattgccatttttcaaaggcag
aagagaagaaagttttggaaagcaaaaaacttacaacacataccattaaagaaaggcaag
agagttgttagctaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (5)   
   PDB (5)   
Protein domain (1)   
   Pfam (1)   
All databases (45)   

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