| Entry |
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| Symbol |
CYLD, BRSS, CDMT, CYLD1, CYLDI, EAC, FTDALS8, MFT, MFT1, SBS, TEM, USPL2
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| Name |
(RefSeq) CYLD lysine 63 deubiquitinase
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| KO |
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| Organism |
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| Pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa04625 | C-type lectin receptor signaling pathway |
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| Network |
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| Element |
| N01625 | CYLD regulation of RIPK1/3 |
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| Disease |
| H00827 | Brooke-Spiegler syndrome |
| H00828 | Familial cylindromatosis |
| H00829 | Multiple familial trichoepithelioma |
| H02342 | Frontotemporal dementia and amyotrophic lateral sclerosis |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
1540 (CYLD)
04668 TNF signaling pathway
1540 (CYLD)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
1540 (CYLD)
09150 Organismal Systems
09151 Immune system
04622 RIG-I-like receptor signaling pathway
1540 (CYLD)
04625 C-type lectin receptor signaling pathway
1540 (CYLD)
09158 Development and regeneration
04380 Osteoclast differentiation
1540 (CYLD)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
1540 (CYLD)
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:hsa04121]
1540 (CYLD)
Enzymes [BR:hsa01000]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.19 Omega peptidases
3.4.19.12 ubiquitinyl hydrolase 1
1540 (CYLD)
Peptidases and inhibitors [BR:hsa01002]
Cysteine peptidases
Family C67
1540 (CYLD)
Ubiquitin system [BR:hsa04121]
Deubiquitinating enzyme (DUB)
Ubiquitin-specific proteases (UBPs)
UBP/USP
1540 (CYLD)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
16:50742086..50801935
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| AA seq |
956 aa
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRI
PSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERFSLFKNRNRLS
KGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKV
GETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFACVESTILLHIN
DIIPALSESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTSDPGNRNRSELFYTLNG
SSVDSQPQSKSKNTWYIDEVAEDPAKSLTEISTDFDRSSPPLQPPPVNSLTTENRFHSLP
FSLTKMPNTNGSIGHSPLSLSAQSVMEELNTAPVQESPPLAMPPGNSHGLEVGSLAEVKE
NPPFYGVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCR
PDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNS
CYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIM
KLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFME
KNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDL
LEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSL
PKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNG
FNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK |
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| NT seq |
2871 nt +upstreamnt +downstreamnt
atgagttcaggcttatggagccaagaaaaagtcacttcaccctactgggaagagcggatt
ttttacttgcttcttcaagaatgcagcgttacagacaaacaaacacaaaagctccttaaa
gtaccgaagggaagtataggacagtatattcaagatcgttctgtggggcattcaaggatt
ccttctgcaaaaggcaagaaaaatcagattggattaaaaattctagagcaacctcatgca
gttctctttgttgatgaaaaggatgttgtagagataaatgaaaagttcacagagttactt
ttggcaattaccaattgtgaggagaggttcagcctgtttaaaaacagaaacagactaagt
aaaggcctccaaatagacgtgggctgtcctgtgaaagtacagctgagatctggggaagaa
aaatttcctggagttgtacgcttcagaggacccctgttagcagagaggacagtctccgga
atattctttggagttgaattgctggaagaaggtcgtggtcaaggtttcactgacggggtg
taccaagggaaacagctttttcagtgtgatgaagattgtggcgtgtttgttgcattggac
aagctagaactcatagaagatgatgacactgcattggaaagtgattacgcaggtcctggg
gacacaatgcaggtcgaacttcctcctttggaaataaactccagagtttctttgaaggtt
ggagaaacaatagaatctggaacagttatattctgtgatgttttgccaggaaaagaaagc
ttaggatattttgttggtgtggacatggataaccctattggcaactgggatggaagattt
gatggagtgcagctttgtagttttgcgtgtgttgaaagtacaattctattgcacatcaat
gatatcatcccagctttatcagagagtgtgacgcaggaaaggaggcctcccaaacttgcc
tttatgtcaagaggtgttggggacaaaggttcatccagtcataataaaccaaaggctaca
ggatctacctcagaccctggaaatagaaacagatctgaattattttataccttaaatggg
tcttctgttgactcacaaccacaatccaaatcaaaaaatacatggtacattgatgaagtt
gcagaagaccctgcaaaatctcttacagagatatctacagactttgaccgttcttcacca
ccactccagcctcctcctgtgaactcactgaccaccgagaacagattccactctttacca
ttcagtctcaccaagatgcccaataccaatggaagtattggccacagtccactttctctg
tcagcccagtctgtaatggaagagctaaacactgcacccgtccaagagagtccacccttg
gccatgcctcctgggaactcacatggtctagaagtgggctcattggctgaagttaaggag
aaccctcctttctatggggtaatccgttggatcggtcagccaccaggactgaatgaagtg
ctcgctggactggaactggaagatgagtgtgcaggctgtacggatggaaccttcagaggc
actcggtatttcacctgtgccctgaagaaggcgctgtttgtgaaactgaagagctgcagg
cctgactctaggtttgcatcattgcagccggtttccaatcagattgagcgctgtaactct
ttagcatttggaggctacttaagtgaagtagtagaagaaaatactccaccaaaaatggaa
aaagaaggcttggagataatgattgggaagaagaaaggcatccagggtcattacaattct
tgttacttagactcaaccttattctgcttatttgcttttagttctgttctggacactgtg
ttacttagacccaaagaaaagaacgatgtagaatattatagtgaaacccaagagctactg
aggacagaaattgttaatcctctgagaatatatggatatgtgtgtgccacaaaaattatg
aaactgaggaaaatacttgaaaaggtggaggctgcatcaggatttacctctgaagaaaaa
gatcctgaggaattcttgaatattctgtttcatcatattttaagggtagaacctttgcta
aaaataagatcagcaggtcaaaaggtacaagattgttacttctatcaaatttttatggaa
aaaaatgagaaagttggcgttcccacaattcagcagttgttagaatggtcttttatcaac
agtaacctgaaatttgcagaggcaccatcatgtctgattattcagatgcctcgatttgga
aaagactttaaactatttaaaaaaatttttccttctctggaattaaatataacagattta
cttgaagacactcccagacagtgccggatatgtggagggcttgcaatgtatgagtgtaga
gaatgctacgacgatccggacatctcagctggaaaaatcaagcagttttgtaaaacctgc
aacactcaagtccaccttcatccgaagaggctgaatcataaatataacccagtgtcactt
cccaaagacttacccgactgggactggagacacggctgcatcccttgccagaatatggag
ttatttgctgttctctgcatagaaacaagccactatgttgcttttgtgaagtatgggaag
gacgattctgcctggctcttctttgacagcatggccgatcgggatggtggtcagaatggc
ttcaacattcctcaagtcaccccatgcccagaagtaggagagtacttgaagatgtctctg
gaagacctgcattccttggactccaggagaatccaaggctgtgcacgaagactgctttgt
gatgcatatatgtgcatgtaccagagtccaacaatgagtttgtacaaataa |
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