KEGG   Homo sapiens (human): 1582
Entry
1582              CDS       T01001                                 
Symbol
CYP8B1, CP8B, CYP12, CYPVIIIB1
Name
(RefSeq) cytochrome P450 family 8 subfamily B member 1
  KO
K07431  sterol 12-alpha-hydroxylase [EC:1.14.14.139]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00120  Primary bile acid biosynthesis
hsa01100  Metabolic pathways
hsa03320  PPAR signaling pathway
Module
hsa_M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Network
nt06022  Bile acid biosynthesis
  Element
N00805  Bile acid biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    1582 (CYP8B1)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    1582 (CYP8B1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1582 (CYP8B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.139  5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
     1582 (CYP8B1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP8 family
   1582 (CYP8B1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1582
NCBI-ProteinID: NP_004382
OMIM: 602172
HGNC: 2653
Ensembl: ENSG00000180432
UniProt: Q9UNU6
Structure
Position
3:complement(42872192..42875879)
AA seq 501 aa
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRM
RTKHGDVFTVQLGGQYFTFVMDPLSFGSILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH
EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTA
GYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQRLFHKML
SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK
HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV
HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFF
KTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW
GFGTMQPSHDVRFRYRLHPTE
NT seq 1506 nt   +upstreamnt  +downstreamnt
atggttctctggggtccagtgctgggagctctgctggtggtcattgctggatacctgtgc
ctgccagggatgctccgacaacgcaggccatgggagccccctctggacaagggtaccgtg
ccctggcttggccatgccatggctttccggaagaatatgtttgaatttctgaagcgcatg
aggaccaagcatggggatgtgttcacagtgcagctagggggccagtacttcaccttcgtc
atggaccccctctcctttggctccatcctcaaggacacacagagaaaactagactttggg
caatatgcaaaaaaactggtgctgaaggtatttggataccgttcagtgcaaggggaccat
gagatgatacactcagccagcaccaagcatctgaggggggatggcttgaaggatcttaat
gagaccatgctggacagcctgtcctttgtaatgctgacgtccaaaggctggagtctggat
gccagttgctggcatgaggacagcctctttcgcttctgctattacatcttgttcacagct
ggctacctgagcttgttcggctacacgaaggacaaggagcaggacctgctacaggcagga
gagttattcatggagttccgcaagtttgaccttcttttcccaaggtttgtctactccctg
ctgtggccccgggagtggctagaagtgggccgactccagcgtctctttcacaagatgctc
tccgtgagccacagccaggagaaggagggcatcagcaactggctgggcaacatgcttcag
tttctgagggagcagggggtaccctcagctatgcaggacaagttcaacttcatgatgctc
tgggcctcccaggggaacacggggcctacctctttctgggccctcttgtacctcctgaag
cacccagaagctattcgggctgtgagggaggaagctacccaggtcctgggtgaggccagg
ctggagaccaagcagtcctttgccttcaaactcggtgccctgcaacacaccccagttcta
gacagcgtggtggaggagacgctgcggctgagggctgcacccaccctcctcaggttggtt
catgaagactataccctgaagatgtccagtgggcaggagtatctgttccgccatggagac
atcctggccctctttccctacctctcagtgcacatggaccctgacatccaccctgagccc
accgtcttcaagtacgatcgcttcctcaaccctaatggcagccggaaagtggacttcttc
aagacaggcaagaagatccaccactacaccatgccctggggttcgggcgtttccatctgc
cctgggaggttctttgcactcagtgaggtgaagctctttatcctgcttatggtcacacac
tttgacttagagttggtggaccctgacacaccactaccccatgttgacccgcagcgctgg
ggttttggcaccatgcagcccagccacgatgtgcgcttccgctaccgcctgcatcctaca
gagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (1)   
   Pfam (1)   
All databases (68)   

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