Entry
Symbol
CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo
Name
(RefSeq) cytochrome P450 family 11 subfamily B member 2
KO
Organism
Pathway
hsa04925 Aldosterone synthesis and secretion
Module
hsa_M00108 C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Network
nt06019 Steroid hormone biosynthesis
nt06310 CRH-ACTH-cortisol signaling
nt06316 Renin-angiotensin-aldosterone signaling
Element
N00298 CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301 Angiotensin-aldosterone signaling pathway
N00302 Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303 Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304 Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305 Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00338 Steroid hormone biosynthesis, progesterone to cortisol/cortisone
N00339 Steroid hormone biosynthesis, progesterone to aldosterone
Disease
H00258 Aldosterone synthase deficiency
H00602 Glucocorticoid-remediable aldosteronism (GRA)
Drug target
Brite
KEGG Orthology (KO) [BR:hsa00001 ]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
1585 (CYP11B2)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
1585 (CYP11B2)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:hsa00199 ]
1585 (CYP11B2)
Enzymes [BR:hsa01000 ]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15.4 steroid 11beta-monooxygenase
1585 (CYP11B2)
1.14.15.5 corticosterone 18-monooxygenase
1585 (CYP11B2)
Cytochrome P450 [BR:hsa00199 ]
Cytochrome P450, animal type
CYP11 family
1585 (CYP11B2)
BRITE hierarchy
SSDB
Ortholog Paralog Gene cluster GFIT
Motif
Motif
Other DBs
Structure
PDB
Position
8:complement(142910559..142917843)
Genome browser
AA seq
503 aa AA seq DB search
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
NT seq
1512 nt NT seq +upstream nt +downstream nt
atggcactcagggcaaaggcagaggtgtgcgtggcagcgccctggctgtccctgcaaagg
gcacgggcactgggcactagagccgctcgggcccctaggacggtgctgccgtttgaagcc
atgccccagcatccaggcaacaggtggctgaggctgctgcagatctggagggagcagggt
tatgagcacctgcacctggagatgcaccagaccttccaggagctggggcccattttcagg
tacaacttgggaggaccacgcatggtgtgtgtgatgctgccggaggatgtggagaagctg
caacaggtggacagcctgcatccctgcaggatgatcctggagccctgggtggcctacaga
caacatcgtgggcacaaatgtggcgtgttcttgttgaatgggcctgaatggcgcttcaac
cgattgcggctgaacccagatgtgctgtcgcccaaggccgtgcagaggttcctcccgatg
gtggatgcagtggccagggacttctcccaggccctgaagaagaaggtgctgcagaacgcc
cgggggagcctgaccctggacgtccagcccagcatcttccactacaccatagaagccagc
aacttagctctttttggagagcggctgggcctggttggccacagccccagttctgccagc
ctgaacttcctccatgccctggaggtcatgttcaaatccaccgtccagctcatgttcatg
cccaggagcctgtctcgctggatcagccccaaggtgtggaaggagcactttgaggcctgg
gactgcatcttccagtacggtgacaactgtatccagaaaatctaccaggaactggccttc
aaccgccctcaacactacacaggcatcgtggcggagctcctgttgaaggcggaactgtca
ctagaagccatcaaggccaactctatggaactcactgcagggagcgtggacacgacagcg
tttcccttgctgatgacgctctttgagctggctcggaaccccgacgtgcagcagatcctg
cgccaggagagcctggccgccgcagccagcatcagtgaacatccccagaaggcaaccacc
gagctgcccttgctgcgggcggccctcaaggagaccttgcggctctaccctgtgggtctg
tttttggagcgagtggtgagctcagacttggtgcttcagaactaccacatcccagctggg
acattggtacaggttttcctctactcgctgggtcgcaatgccgccttgttcccgaggcct
gagcggtataatccccagcgctggctagacatcaggggctccggcaggaacttccaccac
gtgccctttggctttggcatgcgccagtgcctcgggcggcgcctggcagaggcagagatg
ctgctgctgctgcaccacgtgctgaagcacttcctggtggagacactaactcaagaggac
ataaagatggtctacagcttcatattgaggcctggcacgtcccccctcctcactttcaga
gcgattaactag