KEGG   Homo sapiens (human): 1654
Entry
1654              CDS       T01001                                 
Symbol
DDX3X, CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102, MRXSSB
Name
(RefSeq) DEAD-box helicase 3 X-linked
  KO
K11594  ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa05161  Hepatitis B
hsa05203  Viral carcinogenesis
Network
nt06162  Hepatitis B virus (HBV)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
  Element
N00552  HBV pol to TLR3-IRF3 signaling pathway
Disease
H00658  X-linked syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    1654 (DDX3X)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    1654 (DDX3X)
  09172 Infectious disease: viral
   05161 Hepatitis B
    1654 (DDX3X)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1654 (DDX3X)
   03041 Spliceosome [BR:hsa03041]
    1654 (DDX3X)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1654 (DDX3X)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.7  DEAD-box RNA helicase
     1654 (DDX3X)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     1654 (DDX3X)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     1654 (DDX3X)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   RNA helicase-like proteins
    1654 (DDX3X)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Gene silencing
   RISC (RNA-induced silencing complex)
    1654 (DDX3X)
SSDB
Motif
Pfam: DEAD Helicase_C ResIII UTP25
Other DBs
NCBI-GeneID: 1654
NCBI-ProteinID: NP_001347
OMIM: 300160
HGNC: 2745
Ensembl: ENSG00000215301
UniProt: O00571
Structure
Position
X:41333308..41364472
AA seq 662 aa
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGW
SSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFE
RGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILS
QIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVV
YGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV
WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDR
EEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGAR
DYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWW
GN
NT seq 1989 nt   +upstreamnt  +downstreamnt
atgagtcatgtggcagtggaaaatgcgctcgggctggaccagcagtttgctggcctagac
ctgaactcttcagataatcagagtggaggaagtacagccagcaaagggcgctatattcct
cctcatttaaggaaccgagaagctactaaaggtttctacgataaagacagttcagggtgg
agttctagcaaagataaggatgcgtatagcagttttggatctcgtagtgattcaagaggg
aagtctagcttcttcagtgatcgtggaagtggatcaaggggaaggtttgatgatcgtgga
cggagtgattacgatggcattggcagccgtggtgacagaagtggctttggcaaatttgaa
cgtggtggaaacagtcgctggtgtgacaaatcagatgaagatgattggtcaaaaccactc
ccaccaagtgaacgcttggaacaggaactcttttctggaggcaacactgggattaatttt
gagaaatacgatgacattccagttgaggcaacaggcaacaactgtcctccacatattgaa
agtttcagtgatgttgagatgggagaaattatcatgggaaacattgagcttactcgttat
actcgcccaactccagtgcaaaagcatgctattcctattatcaaagagaaaagagacttg
atggcttgtgcccaaacagggtctggaaaaactgcagcatttctgttgcccatcttgagt
cagatttattcagatggtccaggcgaggctttgagggccatgaaggaaaatggaaggtat
gggcgccgcaaacaatacccaatctccttggtattagcaccaacgagagagttggcagta
cagatctacgaggaagccagaaaattttcataccgatctagagttcgtccttgcgtggtt
tatggtggtgccgatattggtcagcagattcgagacttggaacgtggatgccatttgtta
gtagccactccaggacgtctagtggatatgatggaaagaggaaagattggattagacttt
tgcaaatacttggtgttagatgaagctgatcggatgttggatatggggtttgagcctcag
attcgtagaatagtcgaacaagatactatgcctccaaagggtgtccgccacactatgatg
tttagtgctacttttcctaaggaaatacagatgctggctcgtgatttcttagatgaatat
atcttcttggctgtaggaagagttggctctacctctgaaaacatcacacagaaagtagtt
tgggtggaagaatcagacaaacggtcatttctgcttgacctcctaaatgcaacaggcaag
gattcactgaccttagtgtttgtggagaccaaaaagggtgcagattctctggaggatttc
ttataccatgaaggatacgcatgtaccagcatccatggagaccgttctcagagggataga
gaagaggcccttcaccagttccgctcaggaaaaagcccaattttagtggctacagcagta
gcagcaagaggactggacatttcaaatgtgaaacatgttatcaattttgacttgccaagt
gatattgaagaatatgtacatcgtattggtcgtacgggacgtgtaggaaaccttggcctg
gcaacctcattctttaacgagaggaacataaatattactaaggatttgttggatcttctt
gttgaagctaaacaagaagtgccgtcttggttagaaaacatggcttatgaacaccactac
aagggtagcagtcgtggacgttctaagagtagcagatttagtggagggtttggtgccaga
gactaccgacaaagtagcggtgccagcagttccagcttcagcagcagccgcgcaagcagc
agccgcagtggcggaggtggccacggtagcagcagaggatttggtggaggtggctatgga
ggcttttacaacagtgatggatatggaggaaattataactcccagggggttgactggtgg
ggtaactga

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (4)   
   KEGG NETWORK (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (69)   
   RefSeq(nuc) (9)   
   GenBank (30)   
   EMBL (30)   
3D Structure (14)   
   PDB (14)   
Protein domain (4)   
   Pfam (4)   
All databases (137)   

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