KEGG   Homo sapiens (human): 1659
Entry
1659              CDS       T01001                                 
Symbol
DHX8, DDX8, Dhr2, HRH1, PRP22, PRPF22
Name
(RefSeq) DEAH-box helicase 8
  KO
K12818  ATP-dependent RNA helicase DHX8/PRP22 [EC:5.6.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03040  Spliceosome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    1659 (DHX8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:hsa03041]
    1659 (DHX8)
Spliceosome [BR:hsa03041]
 Complex C
  Other components
   Step II factors
    1659 (DHX8)
SSDB
Motif
Pfam: OB_NTP_bind HA2_C S1 Helicase_C HA2_N DEAD AAA_22 AAA_19 nSTAND3 Flavi_DEAD AAA_16 T2SSE TsaE PhoH Sigma54_activ_2 ABC_tran
Other DBs
NCBI-GeneID: 1659
NCBI-ProteinID: NP_004932
OMIM: 600396
HGNC: 2749
Ensembl: ENSG00000067596
UniProt: Q14562 Q86YB2 Q05CV4
Structure
Position
17:43483975..43544799
AA seq 1220 aa
MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN
TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP
VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR
DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK
YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL
RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE
ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD
EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS
ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK
HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ
YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY
MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL
DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL
TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN
IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY
RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ
LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR
PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK
QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA
LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP
LYNRYEEPNAWRISRAFRRR
NT seq 3663 nt   +upstreamnt  +downstreamnt
atggctgtggctgtagccatggcgggagccttaatcgggtcggagccaggccccgcggaa
gaacttgccaaactcgagtacctgtctttggtgtcaaaggtttgcactgagctggacaat
cacttggggatcaacgacaaggaccttgctgaatttgtgatcagtcttgctgagaaaaat
accacctttgatacttttaaggcttctctcgtcaaaaatggtgcagaatttacggattct
cttattagtaacttgctgcgtctcatacaaaccatgcggcctccagcgaagccttccact
agcaaagatccagttgttaaacctaaaacagaaaaagaaaagctgaaggaactcttccca
gtcctttgccaaccggacaacccttctgttcggaccatgttggatgaagatgatgtgaaa
gttgctgtggatgtcctgaaagaactggaagctttaatgcccagcgcagcaggccaggag
aagcaaagagatgctgaacaccgggacaggacaaagaagaagaagcggagtcgaagccga
gatcgaaaccgagatcgagacagagatagggaacgaaaccgagatagagaccacaagcgg
agacaccgatcccgctctcgatcacgttccaggacccgggagaggaataaagtgaagtct
agatatcggtccaggagcaggagtcagagtccccccaaagaccggaaggaccgggacaaa
tatggagagcggaatctggatagatggcgggataagcatgtggaccgccctcctccagaa
gagcccaccattggtgacatttataatggcaaagttaccagcatcatgcagtttggttgc
tttgtgcagctggaaggactaaggaagcggtgggaaggcctggtgcacatctctgagctc
cggcgggagggtcgtgtggccaatgtagctgatgtcgtgagcaaaggccagagggtcaaa
gtcaaagtgctgtccttcactgggaccaagaccagcctgagcatgaaggatgtggatcaa
gagactggagaagatctaaacccaaatagacggcgaaatcttgtcggggagaccaatgag
gagacctcaatgcggaatcctgatagacccactcacttgtcccttgtcagtgctcctgaa
gtagaggacgactcactggaacgcaagcgcctcacccgaatctctgacccagagaagtgg
gagatcaaacagatgattgctgccaatgtcctttccaaagaagaatttccagactttgat
gaagagactggcattctccctaaggtggatgatgaagaagatgaggaccttgagattgaa
ttggttgaggaagagcctccattcctgagagggcacactaagcaaagcatggacatgagc
cccattaaaattgtcaagaacccagacggctccctctcccaagcagcaatgatgcagagt
gccttggccaaagaaaggcgggaactcaaacaggcccagcgggaagctgagatggattct
attcccatgggactcaacaaacactgggttgaccctctgcctgatgcggaaggcagacag
attgctgccaacatgaggggtattgggatgatgcccaatgatattcctgagtggaagaag
catgcctttgggggcaacaaagcctcttacggaaaaaagacccagatgtcaatccttgag
cagagggagagcctgcccatctacaaactgaaggagcaattggtccaggccgtccatgac
aatcagatcctgattgtcattggtgagacaggatctggaaagacaacacagatcacccag
tacctggcggaggcaggctacacttccaggggcaagattgggtgtacccagcccagaaga
gtggcagctatgtcggtggccaaaagagtgtcagaggagtttggttgttgcttaggccaa
gaggtgggctacaccattcgatttgaggactgcactagccctgaaacagtcatcaagtac
atgacagatgggatgttgcttagagagtgcttgattgaccctgacctcactcagtacgcg
atcatcatgttggacgaggcacatgagaggacaattcacactgatgtgctctttggattg
ttgaaaaagacagttcagaaacggcaggacatgaagctgattgtcacctcagccaccttg
gatgcagtgaagttttctcaatacttctatgaagctcccattttcaccatcccaggtcga
acatatccagtggaaatactgtacacaaaggaacctgagacagattatctggatgccagc
ctgattactgttatgcagattcatttaacagaaccaccaggtgatatcctggtcttcctg
actggtcaggaagaaattgatactgcttgtgagatcctgtatgaaagaatgaaatccctg
ggacctgatgttccagagttaattatcctcccagtgtactctgctcttcccagtgagatg
cagacccgaatctttgacccagctccaccaggcagcagaaaggttgtgattgccaccaat
atcgcagagacatcgctgactattgatggtatctactatgtggtggacccaggattcgtg
aaacagaaagtttacaattccaagacagggattgaccagctcgtggtgacgcctatttct
caggctcaggcaaagcaacgagctggcagagctgggagaacaggcccagggaagtgttac
aggttgtacacagaacgtgcctaccgagatgaaatgctgaccaccaacgtgccggaaatc
cagagaaccaacttagcaagcacagtgctgtcactcaaggccatgggtatcaatgatctg
ctgtcctttgatttcatggatgccccacctatggaaactttgatcacagccatggagcag
ctgtacacactgggggccctggatgacgagggcctgctcactcgcttgggccgccggatg
gcagagttccctctggagccaatgctatgcaaaatgctcatcatgtctgtgcatctgggc
tgcagtgaggaaatgctgaccattgtatccatgctgtctgtgcagaacgtcttctatagg
cccaaggataaacaagcccttgcagatcagaagaaggccaaattccaccagactgaaggg
gaccacctcaccctgctagctgtgtacaactcctggaagaacaacaagttctccaaccca
tggtgctatgagaactttatccaggctcgttccctgcgccgggcccaggacattcgcaag
cagatgttaggcataatggacagacacaagctggatgttgtttcctgtggcaagtccaca
gtccgagtgcagaaggccatctgcagtgggttcttccgtaatgctgccaagaaagacccg
caggagggttaccggacactgatcgaccagcaggtggtctatatccatccttccagtgcc
ctcttcaacagacagccagaatgggtggtgtaccatgagctggtgctcaccaccaaggaa
tacatgcgtgaagttaccaccatcgaccctcggtggcttgtggagtttgccccagccttc
ttcaaggtctcagacccaactaagctaagcaaacagaagaagcaacagcgtcttgaaccc
ttgtacaaccgctatgaggaacccaatgcctggagaatatctcgagctttccgacggcgc
tga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (39)   
   KEGG ORTHOLOGY (1)   
   RefGene (29)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (12)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (32)   
   RefSeq(nuc) (12)   
   GenBank (10)   
   EMBL (10)   
3D Structure (13)   
   PDB (13)   
Protein domain (16)   
   Pfam (16)   
All databases (118)   

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