KEGG   Homo sapiens (human): 169355
Entry
169355            CDS       T01001                                 
Symbol
IDO2, INDOL1
Name
(RefSeq) indoleamine 2,3-dioxygenase 2
  KO
K00463  indoleamine 2,3-dioxygenase [EC:1.13.11.52]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05143  African trypanosomiasis
Module
hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
Drug target
Indoximod: D10640
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    169355 (IDO2)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05143 African trypanosomiasis
    169355 (IDO2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.52  indoleamine 2,3-dioxygenase
     169355 (IDO2)
SSDB
Motif
Pfam: IDO PrnB
Other DBs
NCBI-GeneID: 169355
NCBI-ProteinID: NP_919270
OMIM: 612129
HGNC: 27269
Ensembl: ENSG00000188676
UniProt: Q6ZQW0
Position
8:39934651..40016392
AA seq 407 aa
MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQ
AHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSR
NLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVP
GIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSG
WKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYM
PPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAA
KAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
NT seq 1224 nt   +upstreamnt  +downstreamnt
atggagccccacagaccgaatgtgaagacagcagtgccattgtctttggaaagctatcac
atatctgaagagtatggctttcttcttccagattctctgaaagaacttccagatcattat
aggccttggatggaaattgccaacaaacttcctcaattgattgatgctcaccagcttcaa
gctcatgtggacaagatgcccctgctgagctgccagttcctgaagggtcaccgggagcag
cgcctggcccacctggtcctgagcttcctcaccatgggttatgtctggcaggaaggagag
gcgcagcctgcagaggtcctgccaaggaatcttgcccttccatttgtcgaagtctccagg
aacttggggctccctcctatcctggtccactcagacttggtgctgacgaactggaccaaa
aaagatccagacggattcctggaaattgggaacctggagaccatcatctcatttcctggg
ggagagagcctgcatggttttatactggtgactgctttggtagagaaagaagcagtgcct
gggataaaggctcttgttcaggccacgaatgctatcttgcagcccaaccaggaggccctg
ctccaagccctgcagcgactgagactgtctattcaggacatcaccaaaaccttaggacag
atgcatgattatgtagatccagacatattttatgcaggcatccggatctttctctctgga
tggaaagacaacccagcaatgcctgcagggctgatgtatgaaggagtttcccaagagccc
ctgaaatactccggcgggagtgcagctcagagcacagtgcttcatgcctttgatgagttc
ttaggcattcgtcatagcaaggaaagtggtgactttctgtacagaatgagggattacatg
cctccttcccataaggccttcatagaagacatccactcagcaccttccctgagggactac
atcctgtcatctggacaggaccacttgctgacagcttataaccagtgtgtgcaggccctg
gcagagctgcggagctatcacatcaccatggtcaccaaatacctcatcacagctgcagcc
aaggcaaagcatgggaagccaaaccatctcccagggcctcctcaggctttaaaagacagg
ggcacaggtggaaccgcagttatgagctttcttaagagtgtcagggataagaccttggag
tcaatccttcacccacgtggttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (14)   
   RefSeq(nuc) (2)   
   GenBank (6)   
   EMBL (6)   
Protein domain (2)   
   Pfam (2)   
All databases (64)   

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