KEGG   Homo sapiens (human): 1733
Entry
1733              CDS       T01001                                 
Symbol
DIO1, 5DI, THMA2, TXDI1
Name
(RefSeq) iodothyronine deiodinase 1
  KO
K01562  type I thyroxine 5'-deiodinase [EC:1.21.99.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04919  Thyroid hormone signaling pathway
Disease
H01186  Abnormal thyroid hormone metabolism
Drug target
Propylthiouracil: D00562<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    1733 (DIO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.21  Catalysing the reaction X-H + Y-H = X-Y
   1.21.99  With unknown physiological acceptors
    1.21.99.4  thyroxine 5'-deiodinase
     1733 (DIO1)
SSDB
Motif
Pfam: T4_deiodinase DUF2019 SCIMP CoV_NSP4_N
Other DBs
NCBI-GeneID: 1733
NCBI-ProteinID: NP_000783
OMIM: 147892
HGNC: 2883
Ensembl: ENSG00000211452
UniProt: P49895 A8K415
Position
1:53894187..53911086
AA seq 249 aa
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
RAVLEKLHS
NT seq 750 nt   +upstreamnt  +downstreamnt
atggggctgccccagccagggctgtggctgaagaggctctgggtgctcttggaggtggct
gtgcatgtggtcgtgggtaaagtgcttctgatattgtttccagacagagtcaagcggaac
atcctggccatgggcgagaagacgggtatgaccaggaacccccatttcagccacgacaac
tggataccaacctttttcagcacccagtatttctggttcgtcttgaaggtccgttggcag
cgactagaggacacgactgagctagggggtctggccccaaactgcccggtggtccgcctc
tcaggacagaggtgcaacatttgggagtttatgcaaggtaataggccactggtgctgaat
tttggaagttgtacctgaccttcatttatgttcaaatttgaccagttcaagaggcttatt
gaagactttagttccatagcagattttcttgtcatttacattgaagaagcacatgcatca
gatggctgggcttttaagaacaacatggacatcagaaatcaccagaaccttcaggatcgc
ctgcaggcagcccatctactgctggccaggagcccccagtgccctgtggtggtggacacc
atgcagaaccagagcagccagctctacgcagcactgcctgagaggctctacataatccag
gagggcaggatcctctacaagggtaaatctggcccttggaactacaacccagaggaagtt
cgtgctgttctggaaaagctccacagttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (53)   
   RefSeq(nuc) (7)   
   GenBank (23)   
   EMBL (23)   
Protein domain (4)   
   Pfam (4)   
All databases (87)   

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