KEGG   Homo sapiens (human): 1763
Entry
1763              CDS       T01001                                 
Symbol
DNA2, DNA2L, hDNA2
Name
(RefSeq) DNA replication helicase/nuclease 2
  KO
K10742  DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Network
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01446  DNA end resection and RPA loading
N01472  Okazaki fragment maturation
Disease
H00992  Seckel syndrome
H01118  Progressive external ophthalmoplegia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    1763 (DNA2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    1763 (DNA2)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     1763 (DNA2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   Other elongation factors
    1763 (DNA2)
 Prokaryotic type
   Elongation factors (archaeal)
    Other elongation factors
     1763 (DNA2)
SSDB
Motif
Pfam: Dna2 AAA_12 Dna2_Rift AAA_11 AAA_30 AAA_19 PDDEXK_1 UvrD-helicase nSTAND3 Cas_Cas4 SRP54 bpMoxR DEAD UvrD_C_2 ResIII AAA_25 CbiA SLFN-g3_helicase AAA_22 MobB AAA_7 AAA_18 AAA PhoH YqeC
Other DBs
NCBI-GeneID: 1763
NCBI-ProteinID: NP_001073918
OMIM: 601810
HGNC: 2939
Ensembl: ENSG00000138346
UniProt: P51530
Structure
Position
10:complement(68414064..68472521)
AA seq 1060 aa
MEQLNELELLMEKSFWEEAELPAELFQKKVVASFPRTVLSTGMDNRYLVLAVNTVQNKEG
NCEKRLVITASQSLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILY
PDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQ
ELAFQTIQEIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNTSTDFPQMQLSL
PSDNSKDNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELK
TGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPANHLDKRELLKLRNQ
MAFSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDCSSVPI
VMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIG
NLIRMEHVKIVCDGQYLHNFQCKHGAIPVTNLMAGDRVIVSGEERSLFALSRGYVKEINM
TTVTCLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTFVSKKLRDLIIDFRE
PQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICT
LVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQQFTEQEICRS
KSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFSR
RFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSAVVQLTVQYRMNSKIMSLSNKL
TYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMGVFEPNNPVCFLNTDKV
PAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPSDIGIIAPYRQQLKIINDLLARSIGM
VEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRLNVAITRAKHKLILLGCVPSL
NCYPPLEKLLNHLNSEKLIIDLPSREHESLCHILGDFQRE
NT seq 3183 nt   +upstreamnt  +downstreamnt
atggagcagctgaacgaactggagctgctgatggagaagagtttttgggaggaggcggag
ctgccggcggagctatttcagaagaaagtggtagcttcctttccaagaacagttctgagc
acaggaatggataaccggtacctggtgttggcagtcaatactgtacagaacaaagaggga
aactgtgaaaagcgcctggtcatcactgcttcacagtcactagaaaataaagaactatgc
atccttaggaatgactggtgttctgttccagtagagccaggagatatcattcatttggag
ggagactgcacatctgacacttggataatagataaagattttggatatttgattctgtat
ccagacatgctgatttctggcaccagcatagccagtagtattcgatgtatgagaagagct
gtcctgagtgaaacttttaggagctctgatccagccacacgccaaatgctaattggtacg
gttctccatgaggtgtttcaaaaagccataaataatagctttgccccagaaaagctacaa
gaacttgcttttcaaacaattcaagaaataagacatttgaaggaaatgtaccgcttaaat
ctaagtcaagatgaaataaaacaagaagtagaggactatcttccttcgttttgtaaatgg
gcaggagatttcatgcataaaaacacttcgactgacttccctcagatgcagctctctctg
ccaagtgataatagtaaggataattcaacatgtaacattgaagtcgtgaaaccaatggat
attgaagaaagcatttggtcccctaggtttggattgaaaggcaaaatagatgttacagtt
ggtgtgaaaatacatcgagggtataaaacaaaatacaagataatgccgctggaacttaaa
actggcaaagaatcaaattctattgaacaccgtagtcaggttgttctgtacactctacta
agccaagagagaagagctgatccagaggctggcttgcttctctacctcaagactggtcag
atgtaccctgtgcctgccaaccatctagataaaagagaattattaaagctaagaaaccag
atggcattctcattgtttcaccgtattagcaaatctgctactagacagaagacacagctt
gcttctttgccacaaataattgaggaagagaaaacttgtaaatattgttcacaaattggc
aattgtgctctttatagcagagcagttgaacaacagatggattgtagttcagtcccaatt
gtgatgctgcccaaaatagaagaagaaacccagcatctgaagcaaacacacttagaatat
ttcagcctttggtgtctaatgttaaccctggagtcacaatcgaaggataataaaaagaat
caccaaaatatctggctaatgcctgcttcggaaatggagaagagtggcagttgcattgga
aacctgattagaatggaacatgtaaagatagtttgtgatgggcaatatttacataatttc
caatgtaaacatggtgccatacctgtcacaaatctaatggcaggtgacagagttattgta
agtggagaagaaaggtcactgtttgctttgtctagaggatatgtgaaggagattaacatg
acaacagtaacttgtttattagacagaaacttgtcggtccttccagaatcaactttgttc
agattagaccaagaagaaaaaaattgtgatatagataccccattaggaaatctttccaaa
ttgatggaaaacacgtttgtcagcaaaaaacttcgagatttaattattgactttcgtgaa
cctcagtttatatcctaccttagttctgttcttccacatgatgcaaaggatacagttgcc
tgcattctaaagggtttgaataagcctcagaggcaagcgatgaaaaaggtacttctttca
aaagactacacactcatcgtgggtatgcctgggacaggaaaaacaactacgatatgtact
ctcgtaagaattctctacgcctgtggttttagcgttttgttgaccagctatacacactct
gctgttgacaatattcttttgaagttagccaagtttaaaataggatttttgcgtttgggt
cagattcagaaggttcatccagctatccagcaatttacagagcaagaaatttgcagatca
aagtccattaaatccttagctcttctagaagaactctacaatagtcaacttatagttgca
acaacatgtatgggaataaaccatccaatattttcccgtaaaatttttgatttttgtatt
gtggatgaagcctctcaaattagccaaccaatttgtctgggccccctttttttttcacgg
agatttgtgttagtgggggaccatcagcagcttcctcccctggtgctaaaccgtgaagca
agagctcttggcatgagtgaaagcttattcaagaggctggagcagaataagagtgctgtt
gtacagttaaccgtgcagtacagaatgaacagtaaaattatgtccttaagtaataagctg
acctatgagggcaagctggagtgtggatcagacaaagtggccaatgcagtgataaaccta
cgtcactttaaagatgtgaagctggaactggaattttatgctgactattctgataatcct
tggttgatgggagtatttgaacccaacaatcctgtttgtttccttaatacagacaaggtt
ccagcgccagaacaagttgaaaaaggtggtgtgagcaatgtaacagaagccaaactcata
gttttcctaacctccatttttgttaaggctggatgcagtccctctgatattggtattatt
gcaccgtacaggcagcaattaaagatcatcaatgatttattggcacgttctattgggatg
gtcgaagttaatacagtagacaaataccaaggaagggacaaaagtattgtcctagtatct
tttgttagaagtaataaggatggaactgttggtgaactcttgaaagattggcgacgtctt
aatgttgctataaccagagccaaacataaactgattcttctggggtgtgtgccctcacta
aattgctatcctcctttggagaagctgcttaatcatttaaactcagaaaaattaatcatt
gatcttccatcaagagaacatgaaagtctttgccacatattgggtgactttcaaagagaa
taa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (4)   
   KEGG NETWORK (4)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (32)   
   RefSeq(nuc) (8)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (25)   
   Pfam (25)   
All databases (106)   

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