KEGG   Homo sapiens (human): 1786
Entry
1786              CDS       T01001                                 
Symbol
DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
Name
(RefSeq) DNA methyltransferase 1
  KO
K00558  DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa05206  MicroRNAs in cancer
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
  Element
N01607  Methionine degradation
Disease
H00265  Hereditary sensory and autonomic neuropathy
Drug target
Azacitidine: D03021<JP/US>
Decitabine: D03665<US>
Roducitabine: D11740
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1786 (DNMT1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    1786 (DNMT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1786 (DNMT1)
   03032 DNA replication proteins [BR:hsa03032]
    1786 (DNMT1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1786 (DNMT1)
  09183 Protein families: signaling and cellular processes
   02048 Prokaryotic defense system [BR:hsa02048]
    1786 (DNMT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1786 (DNMT1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    1786 (DNMT1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    1786 (DNMT1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    1786 (DNMT1)
Prokaryotic defense system [BR:hsa02048]
 Restriction and modification system (R-M system)
  Type II R-M system
   DNA methyltransferases
    1786 (DNMT1)
SSDB
Motif
Pfam: BAH DNMT1-RFD DNA_methylase DMAP_binding zf-CXXC HTH_12
Other DBs
NCBI-GeneID: 1786
NCBI-ProteinID: NP_001370
OMIM: 126375
HGNC: 2976
Ensembl: ENSG00000130816
UniProt: P26358 I6L9H2
Structure
Position
19:complement(10133346..10194953)
AA seq 1616 aa
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
GMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEK
EEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPE
EKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYL
DDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC
PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFS
TSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGL
NLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQAR
RQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQ
QPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQ
GKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVT
ALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLA
EMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPR
KEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNK
FYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGP
NRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLR
TLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMA
GETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP
RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNG
ASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLP
NIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCL
PHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFP
DTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
NT seq 4851 nt   +upstreamnt  +downstreamnt
atgccggcgcgtaccgccccagcccgggtgcccacactggccgtcccggccatctcgctg
cccgacgatgtccgcaggcggctcaaagatttggaaagagacagcttaacagaaaaggaa
tgtgtgaaggagaaattgaatctcttgcacgaatttctgcaaacagaaataaagaatcag
ttatgtgacttggaaaccaaattacgtaaagaagaattatccgaggagggctacctggct
aaagtcaaatcccttttaaataaagatttgtccttggagaacggtgctcatgcttacaac
cgggaagtgaatggacgtctagaaaacgggaaccaagcaagaagtgaagcccgtagagtg
ggaatggcagatgccaacagcccccccaaacccctttccaaacctcgcacgcccaggagg
agcaagtccgatggagaggctaagcctgaaccttcacctagccccaggattacaaggaaa
agcaccaggcaaaccaccatcacatctcattttgcaaagggccctgccaaacggaaacct
caggaagagtctgaaagagccaaatcggatgagtccatcaaggaagaagacaaagaccag
gatgagaagagacgtagagttacatccagagaacgagttgctagaccgcttcctgcagaa
gaacctgaaagagcaaaatcaggaacgcgcactgaaaaggaagaagaaagagatgaaaaa
gaagaaaagagactccgaagtcaaaccaaagaaccaacacccaaacagaaactgaaggag
gagccggacagagaagccagggcaggcgtgcaggctgacgaggacgaagatggagacgag
aaagatgagaagaagcacagaagtcaacccaaagatctagctgccaaacggaggcccgaa
gaaaaagaacctgaaaaagtaaatccacagatttctgatgaaaaagacgaggatgaaaag
gaggagaagagacgcaaaacgacccccaaagaaccaacggagaaaaaaatggctcgcgcc
aaaacagtcatgaactccaagacccaccctcccaagtgcattcagtgcgggcagtacctg
gacgaccctgacctcaaatatgggcagcacccaccagacgcggtggatgagccacagatg
ctgacaaatgagaagctgtccatctttgatgccaacgagtctggctttgagagttatgag
gcgcttccccagcacaaactgacctgcttcagtgtgtactgtaagcacggtcacctgtgt
cccatcgacaccggcctcatcgagaagaatatcgaactcttcttttctggttcagcaaaa
ccaatctatgatgatgacccatctcttgaaggtggtgttaatggcaaaaatcttggcccc
ataaatgaatggtggatcactggctttgatggaggtgaaaaggccctcatcggcttcagc
acctcatttgccgaatacattctgatggatcccagtcccgagtatgcgcccatatttggg
ctgatgcaggagaagatctacatcagcaagattgtggtggagttcctgcagagcaattcc
gactcgacctatgaggacctgatcaacaagatcgagaccacggttcctccttctggcctc
aacttgaaccgcttcacagaggactccctcctgcgacacgcgcagtttgtggtggagcag
gtggagagttatgacgaggccggggacagtgatgagcagcccatcttcctgacaccctgc
atgcgggacctgatcaagctggctggggtcacgctgggacagaggcgagcccaggcgagg
cggcagaccatcaggcattctaccagggagaaggacaggggacccacgaaagccaccacc
accaagctggtctaccagatcttcgatactttcttcgcagagcaaattgaaaaggatgac
agagaagacaaggagaacgcctttaagcgccggcgatgtggcgtctgtgaggtgtgtcag
cagcctgagtgtgggaaatgtaaagcctgcaaggacatggttaaatttggtggcagtgga
cggagcaagcaggcttgccaagagcggaggtgtcccaatatggccatgaaggaggcagat
gacgatgaggaagtcgatgataacatcccagagatgccgtcacccaaaaaaatgcaccag
gggaagaagaagaaacagaacaagaatcgcatctcttgggtcggagaagccgtcaagact
gatgggaagaagagttactataagaaggtgtgcattgatgcggaaaccctggaagtgggg
gactgtgtctctgttattccagatgattcctcaaaaccgctgtatctagcaagggtcacg
gcgctgtgggaggacagcagcaacgggcagatgtttcacgcccactggttctgcgctggg
acagacacagtcctcggggccacgtcggaccctctggagctgttcttggtggatgaatgt
gaggacatgcagctttcatatatccacagcaaagtgaaagtcatctacaaagccccctcc
gaaaactgggccatggagggaggcatggatcccgagtccctgctggagggggacgacggg
aagacctacttctaccagctgtggtatgatcaagactacgcgagattcgagtcccctcca
aaaacccagccaacagaggacaacaagttcaaattctgtgtgagctgtgcccgtctggct
gagatgaggcaaaaagaaatccccagggtcctggagcagctcgaggacctggatagccgg
gtcctctactactcagccaccaagaacggcatcctgtaccgagttggtgatggtgtgtac
ctgccccctgaggccttcacgttcaacatcaagctgtccagtcccgtgaaacgcccacgg
aaggagcccgtggatgaggacctgtacccagagcactaccggaaatactccgactacatc
aaaggcagcaacctggatgcccctgagccctaccgaattggccggatcaaagagatcttc
tgtcccaagaagagcaacggcaggcccaatgagactgacatcaaaatccgggtcaacaag
ttctacaggcctgagaacacccacaagtccactccagcgagctaccacgcagacatcaac
ctgctctactggagcgacgaggaggccgtggtggacttcaaggctgtgcagggccgctgc
accgtggagtatggggaggacctgcccgagtgcgtccaggtgtactccatgggcggcccc
aaccgcttctacttcctcgaggcctataatgcaaagagcaaaagctttgaagatcctccc
aaccatgcccgtagccctggaaacaaagggaagggcaagggaaaagggaagggcaagccc
aagtcccaagcctgtgagccgagcgagccagagatagagatcaagctgcccaagctgcgg
accctggatgtgttttctggctgcggggggttgtcggagggattccaccaagcaggcatc
tctgacacgctgtgggccatcgagatgtgggaccctgcggcccaggcgttccggctgaac
aaccccggctccacagtgttcacagaggactgcaacatcctgctgaagctggtcatggct
ggggagaccaccaactcccgcggccagcggctgccccagaagggagacgtggagatgctg
tgcggcgggccgccctgccagggcttcagcggcatgaaccgcttcaattcgcgcacctac
tccaagttcaaaaactctctggtggtttccttcctcagctactgcgactactaccggccc
cggttcttcctcctggagaatgtcaggaactttgtctccttcaagcgctccatggtcctg
aagctcaccctccgctgcctggtccgcatgggctatcagtgcaccttcggcgtgctgcag
gccggtcagtacggcgtggcccagactaggaggcgggccatcatcctggccgcggcccct
ggagagaagctccctctgttcccggagccactgcacgtgtttgctccccgggcctgccag
ctgagcgtggtggtggatgacaagaagtttgtgagcaacataaccaggttgagctcgggt
cctttccggaccatcacggtgcgagacacgatgtccgacctgccggaggtgcggaatgga
gcctcggcactggagatctcctacaacggggagcctcagtcctggttccagaggcagctc
cggggcgcacagtaccagcccatcctcagggaccacatctgtaaggacatgagtgcattg
gtggctgcccgcatgcggcacatccccttggccccagggtcagactggcgcgatctgccc
aacatcgaggtgcggctctcagacggcaccatggccaggaagctgcggtatacccaccat
gacaggaagaacggccgcagcagctctggggccctccgtggggtctgctcctgcgtggaa
gccggcaaagcctgcgaccccgcagccaggcagttcaacaccctcatcccctggtgcctg
ccccacaccgggaaccggcacaaccactgggctggcctctatggaaggctcgagtgggac
ggcttcttcagcacaaccgtcaccaaccccgagcccatgggcaagcagggccgcgtgctc
cacccagagcagcaccgtgtggtgagcgtgcgggagtgtgcccgctcccagggcttccct
gacacctaccggctcttcggcaacatcctggacaagcaccggcaggtgggcaatgccgtg
ccaccgcccctggccaaagccattggcttggagatcaagctttgtatgttggccaaagcc
cgagagagtgcctcagctaaaataaaggaggaggaagctgctaaggactag

  All links  
Ontology (6)   
   KEGG BRITE (6)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Drug (3)   
   KEGG DRUG (3)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (28)   
   RefSeq(nuc) (4)   
   GenBank (12)   
   EMBL (12)   
3D Structure (21)   
   PDB (21)   
Protein domain (6)   
   Pfam (6)   
All databases (125)   

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