KEGG   Homo sapiens (human): 1807
Entry
1807              CDS       T01001                                 
Symbol
DPYS, DHP, DHPase
Name
(RefSeq) dihydropyrimidinase
  KO
K01464  dihydropyrimidinase [EC:3.5.2.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00410  beta-Alanine metabolism
hsa00770  Pantothenate and CoA biosynthesis
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
Module
hsa_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Disease
H00199  Dihydropyrimidinase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    1807 (DPYS)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    1807 (DPYS)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    1807 (DPYS)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    1807 (DPYS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1807 (DPYS)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.2  dihydropyrimidinase
     1807 (DPYS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1807 (DPYS)
SSDB
Motif
Pfam: Amidohydro_1 Amidohydro_3 Amidohydro_2
Other DBs
NCBI-GeneID: 1807
NCBI-ProteinID: NP_001376
OMIM: 613326
HGNC: 3013
Ensembl: ENSG00000147647
UniProt: Q14117
Structure
Position
8:complement(104379431..104467055)
AA seq 519 aa
MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVL
PGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSW
ADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFS
RCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAV
NCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPP
LRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIW
EKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHH
QAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRD
RTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP
NT seq 1560 nt   +upstreamnt  +downstreamnt
atggcggcgccctcgcggctcctgatccgcgggggtcgcgtggtcaacgatgacttctcg
gaggtggccgacgtgctggtggaggacggcgtggtgcgggcactcgggcacgacctgctg
cctcccgggggcgctcctgcggggctgcgggtcctcgacgccgccggcaagctcgtcctg
cccggaggcatcgacacacacacgcacatgcagttccccttcatgggctcgcggtccatc
gacgacttccaccagggcaccaaggctgctctctcaggaggcaccaccatgattattgat
ttcgccattcctcagaaaggtggctccctcattgaggccttcgagacctggcgaagctgg
gctgatcccaaagtttgctgcgactacagccttcatgtggcagtgacgtggtggagtgac
caggttaaagaagaaatgaaaatccttgtgcaagataaaggtgttaactctttcaagatg
tttatggcctataaagatctgtacatggtgacagacctggagctgtacgaagccttctct
cggtgcaaggaaattggagcaattgcccaggtccatgcggaaaatggagacttaattgca
gagggagcaaagaagatgttggctctggggataacaggccctgagggccacgagctgtgc
cgcccagaggcagtggaggcagaggccacgctgagagccatcaccatagccagcgctgtg
aactgtcctctctacattgtgcatgtgatgagcaagtctgcagctaaggtgatagcggat
gcaaggagagatgggaaggtggtctatggtgaacccatagcagccagtcttggcacagat
ggcactcactactggaataaagaatggcaccatgcagcccaccatgtcatgggtccacct
ttgcgaccagacccctcaacacccgacttcctcatgaatctgttggctaatgatgatcta
accacaacagggactgataactgcactttcaacacctgccagaaagctcttgggaaggat
gattttaccaagatccccaatggggtgaatggtgttgaagatcggatgtccgtaatatgg
gaaaaaggcgtgcatagtggtaaaatggatgaaaacagatttgtggcagttaccagcaca
aatgcagccaaaatttttaatctctatccaagaaaaggaagaatagctgtaggatcagat
gctgacattgttatttgggacccaaaaggcacaaggactatctcagcaaaaactcatcat
caggctgttaacttcaacattttcgagggcatggtttgccacggggtgccccttgtgact
atttcaagaggcaaagtggtatatgaagccggagtgttcagtgtcacggcaggagatggg
aagtttattcctcgaaaaccatttgctgaatatatttacaaacgaataaagcagcgagac
cggacttgcacacctacccctgtggagcgtgcaccctataagggagaagtcgccacactg
aaatccagagtgacaaaagaagatgccacagcagggaccaggaaacaggcccacccctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (17)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (23)   
   RefSeq(nuc) (17)   
   GenBank (3)   
   EMBL (3)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (94)   

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