KEGG   Homo sapiens (human): 1843
Entry
1843              CDS       T01001                                 
Symbol
DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10
Name
(RefSeq) dual specificity phosphatase 1
  KO
K21278  dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04726  Serotonergic synapse
hsa05012  Parkinson disease
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06463  Parkinson disease
nt06526  MAPK signaling
  Element
N01058  Mutation-inactivated DJ1 to to p53-mediated transcription
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1843 (DUSP1)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1843 (DUSP1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    1843 (DUSP1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1843 (DUSP1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    1843 (DUSP1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     1843 (DUSP1)
    3.1.3.48  protein-tyrosine-phosphatase
     1843 (DUSP1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    1843 (DUSP1)
SSDB
Motif
Pfam: DSPc Rhodanese Y_phosphatase Init_tRNA_PT PTPlike_phytase
Other DBs
NCBI-GeneID: 1843
NCBI-ProteinID: NP_004408
OMIM: 600714
HGNC: 3064
Ensembl: ENSG00000120129
UniProt: P28562 B4DU40
Structure
Position
5:complement(172768096..172771195)
AA seq 367 aa
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC
NT seq 1104 nt   +upstreamnt  +downstreamnt
atggtcatggaagtgggcaccctggacgctggaggcctgcgggcgctgctgggggagcga
gcggcgcaatgcctgctgctggactgccgctccttcttcgctttcaacgccggccacatc
gccggctctgtcaacgtgcgcttcagcaccatcgtgcggcgccgggccaagggcgccatg
ggcctggagcacatcgtgcccaacgccgagctccgcggccgcctgctggccggcgcctac
cacgccgtggtgttgctggacgagcgcagcgccgccctggacggcgccaagcgcgacggc
accctggccctggcggccggcgcgctctgccgcgaggcgcgcgccgcgcaagtcttcttc
ctcaaaggaggatacgaagcgttttcggcttcctgcccggagctgtgcagcaaacagtcg
acccccatggggctcagccttcccctgagtactagcgtccctgacagcgcggaatctggg
tgcagttcctgcagtaccccactctacgatcagggtggcccggtggaaatcctgcccttt
ctgtacctgggcagtgcgtatcacgcttcccgcaaggacatgctggatgccttgggcatc
actgccttgatcaacgtctcagccaattgtcccaaccattttgagggtcactaccagtac
aagagcatccctgtggaggacaaccacaaggcagacatcagctcctggttcaacgaggcc
attgacttcatagactccatcaagaatgctggaggaagggtgtttgtccactgccaggca
ggcatttcccggtcagccaccatctgccttgcttaccttatgaggactaatcgagtcaag
ctggacgaggcctttgagtttgtgaagcagaggcgaagcatcatctctcccaacttcagc
ttcatgggccagctgctgcagtttgagtcccaggtgctggctccgcactgttcggcagag
gctgggagccccgccatggctgtgctcgaccgaggcacctccaccaccaccgtgttcaac
ttccccgtctccatccctgtccactccacgaacagtgcgctgagctaccttcagagcccc
attacgacctctcccagctgctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (71)   

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