KEGG   Homo sapiens (human): 1846
Entry
1846              CDS       T01001                                 
Symbol
DUSP4, HVH2, MKP-2, MKP2, TYP
Name
(RefSeq) dual specificity phosphatase 4
  KO
K04459  dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04148  Efferocytosis
Network
nt06526  MAPK signaling
nt06535  Efferocytosis
  Element
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
N01774  ERK-DUSP4 negative feedback pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1846 (DUSP4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1846 (DUSP4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    1846 (DUSP4)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     1846 (DUSP4)
    3.1.3.48  protein-tyrosine-phosphatase
     1846 (DUSP4)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    1846 (DUSP4)
SSDB
Motif
Pfam: DSPc Rhodanese Y_phosphatase CDKN3 PTPlike_phytase
Other DBs
NCBI-GeneID: 1846
NCBI-ProteinID: NP_001385
OMIM: 602747
HGNC: 3070
Ensembl: ENSG00000120875
UniProt: Q13115
Structure
Position
8:complement(29333064..29350684)
AA seq 394 aa
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY
ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE
DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD
LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY
QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR
VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP
TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
NT seq 1185 nt   +upstreamnt  +downstreamnt
atggtgacgatggaggagctgcgggagatggactgcagtgtgctcaaaaggctgatgaac
cgggacgagaatggcggcggcgcgggcggcagcggcagccacggcaccctggggctgccg
agcggcggcaagtgcctgctgctggactgcagaccgttcctggcgcacagcgcgggctac
atcctaggttcggtcaacgtgcgctgtaacaccatcgtgcggcggcgggctaagggctcc
gtgagcctggagcagatcctgcccgccgaggaggaggtacgcgcccgcttgcgctccggc
ctctactcggcggtcatcgtctacgacgagcgcagcccgcgcgccgagagcctccgcgag
gacagcaccgtgtcgctggtggtgcaggcgctgcgccgcaacgccgagcgcaccgacatc
tgcctgctcaaaggcggctatgagaggttttcctccgagtacccagaattctgttctaaa
accaaggccctggcagccatcccacccccggttccccccagtgccacagagcccttggac
ctgggctgcagctcctgtgggaccccactacacgaccaggggggtcctgtggagatcctt
cccttcctctacctcggcagtgcctaccatgctgcccggagagacatgctggacgccctg
ggcatcacggctctgttgaatgtctcctcggactgcccaaaccactttgaaggacactat
cagtacaagtgcatcccagtggaagataaccacaaggccgacatcagctcctggttcatg
gaagccatagagtacatcgatgccgtgaaggactgccgtgggcgcgtgctggtgcactgc
caggcgggcatctcgcggtcggccaccatctgcctggcctacctgatgatgaagaaacgg
gtgaggctggaggaggccttcgagttcgttaagcagcgccgcagcatcatctcgcccaac
ttcagcttcatggggcagctgctgcagttcgagtcccaggtgctggccacgtcctgtgct
gcggaggctgctagcccctcgggacccctgcgggagcggggcaagacccccgccaccccc
acctcgcagttcgtcttcagctttccggtctccgtgggcgtgcactcggcccccagcagc
ctgccctacctgcacagccccatcaccacctctcccagctgttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (65)   

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