KEGG   Homo sapiens (human): 1859
Entry
1859              CDS       T01001                                 
Symbol
DYRK1A, DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Name
(RefSeq) dual specificity tyrosine phosphorylation regulated kinase 1A
  KO
K08825  dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]
Organism
hsa  Homo sapiens (human)
Disease
H00773  Autosomal dominant intellectual developmental disorder
Drug target
Lorecivivint: D11588
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1859 (DYRK1A)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1859 (DYRK1A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.1  dual-specificity kinase
     1859 (DYRK1A)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  DYRK family [OT]
   1859 (DYRK1A)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Kinases
    1859 (DYRK1A)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Filament_head
Other DBs
NCBI-GeneID: 1859
NCBI-ProteinID: NP_001387
OMIM: 600855
HGNC: 3091
Ensembl: ENSG00000157540
UniProt: Q13627
Structure
Position
21:37365573..37526358
AA seq 763 aa
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
NT seq 2292 nt   +upstreamnt  +downstreamnt
atgcatacaggaggagagacttcagcatgcaaaccttcatctgttcggcttgcaccgtca
ttttcattccatgctgctggccttcagatggctggacagatgccccattcacatcagtac
agtgaccgtcgccagccaaacataagtgaccaacaggtttctgccttatcatattctgac
cagattcagcaacctctaactaaccaggtgatgcctgatattgtcatgttacagaggcgg
atgccccaaaccttccgtgacccagcaactgctcccctgagaaaactttctgttgacttg
atcaaaacatacaagcatattaatgaggtttactatgcaaaaaagaagcgaagacaccaa
cagggccagggagacgattctagtcataagaaggaacggaaggtttacaatgatggttat
gatgatgataactatgattatattgtaaaaaacggagaaaagtggatggatcgttacgaa
attgactccttgataggcaaaggttcctttggacaggttgtaaaggcatatgatcgtgtg
gagcaagaatgggttgccattaaaataataaagaacaagaaggcttttctgaatcaagca
cagatagaagtgcgacttcttgagctcatgaacaaacatgacactgaaatgaaatactac
atagtgcatttgaaacgccactttatgtttcgaaaccatctctgtttagtttttgaaatg
ctgtcctacaacctctatgacttgctgagaaacaccaatttccgaggggtctctttgaac
ctaacacgaaagtttgcgcaacagatgtgcactgcactgcttttccttgcgactccagaa
cttagtatcattcactgtgatctaaaacctgaaaatatccttctttgtaaccccaaacgc
agtgcaatcaagatagttgactttggcagttcttgtcagttggggcagaggatataccag
tatattcagagtcgcttttatcggtctccagaggtgctactgggaatgccttatgacctt
gccattgatatgtggtccctcgggtgtattttggttgaaatgcacactggagaacctctg
ttcagtggtgccaatgaggtagatcagatgaataaaatagtggaagttctgggtattcca
cctgctcatattcttgaccaagcaccaaaagcaagaaagttctttgagaagttgccagat
ggcacttggaacttaaagaagaccaaagatggaaaacgggagtacaaaccaccaggaacc
cgtaaacttcataacattcttggagtggaaacaggaggacctggtgggcgacgtgctggg
gagtcaggtcatacggtcgctgactacttgaagttcaaagacctcattttaaggatgctt
gattatgaccccaaaactcgaattcaaccttattatgctctgcagcacagtttcttcaag
aaaacagctgatgaaggtacaaatacaagtaatagtgtatctacaagccccgccatggag
cagtctcagtcttcgggcaccacctccagtacatcgtcaagctcaggtggctcatcgggg
acaagcaacagtgggagagcccggtcggatccgacgcaccagcatcggcacagtggtggg
cacttcacagctgccgtgcaggccatggactgcgagacacacagtccccaggtgcgtcag
caatttcctgctcctcttggttggtcaggcactgaagctcctacacaggtcactgttgaa
actcatcctgttcaagaaacaacctttcatgtagcccctcaacagaatgcattgcatcat
caccatggtaacagttcccatcaccatcaccaccaccaccaccatcaccaccaccatgga
caacaagccttgggtaaccggaccaggccaagggtctacaattctccaacgaatagctcc
tctacccaagattctatggaggttggccacagtcaccactccatgacatccctgtcttcc
tcaacgacttcttcctcgacatcttcctcctctactggtaaccaaggcaatcaggcctac
cagaatcgcccagtggctgctaataccttggactttggacagaatggagctatggacgtt
aatttgaccgtctactccaatccccgccaagagactggcatagctggacatccaacatac
caattttctgctaatacaggtcctgcacattacatgactgaaggacatctgacaatgagg
caaggggctgatagagaagagtcccccatgacaggagtttgtgtgcaacagagtcctgta
gctagctcgtga

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Ontology (4)   
   KEGG BRITE (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (42)   
   RefSeq(nuc) (8)   
   GenBank (17)   
   EMBL (17)   
3D Structure (78)   
   PDB (78)   
Protein domain (3)   
   Pfam (3)   
All databases (156)   

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