KEGG T01001: 1869

Homo sapiens (human): 1869

Entry

1869              CDS       T01001

Symbol

E2F1, E2F-1, RBAP1, RBBP3, RBP3

Name

(RefSeq) E2F transcription factor 1

K17454

transcription factor E2F1

Organism

hsa Homo sapiens (human)

Pathway

hsa01522

Endocrine resistance

hsa04110

Cell cycle

hsa04137

Mitophagy - animal

hsa04218

Cellular senescence

hsa04934

Cushing syndrome

hsa05160

Hepatitis C

hsa05161

Hepatitis B

hsa05163

Human cytomegalovirus infection

hsa05165

Human papillomavirus infection

hsa05166

Human T-cell leukemia virus 1 infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05169

Epstein-Barr virus infection

hsa05200

Pathways in cancer

hsa05206

MicroRNAs in cancer

hsa05207

Chemical carcinogenesis - receptor activation

hsa05212

Pancreatic cancer

hsa05214

Glioma

hsa05215

Prostate cancer

hsa05218

Melanoma

hsa05219

Bladder cancer

hsa05220

Chronic myeloid leukemia

hsa05222

Small cell lung cancer

hsa05223

Non-small cell lung cancer

hsa05224

Breast cancer

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
nt06360  Cushing syndrome

Element

N00066

MDM2-p21-Cell cycle G1/S

N00067

Deleted p14(ARF) to p21-cell cycle G1/S

N00068

Amplified MDM2 to p21-cell cycle G1/S

N00069

p16-Cell cycle G1/S

N00070

Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S

N00071

Deleted p16(INK4a) to p16-cell cycle G1/S

N00072

Amplified CDK4 to cell cycle G1/S

N00073

Mutation-activated CDK4 to cell cycle G1/S

N00074

Loss of RB1 to cell cycle G1/S

N00075

Mutation-inactivated RB1 to cell cycle G1/S

N00076

Mutation-inactivated p14(ARF) to p21-cell cycle G1/S

N00088

Amplified MYC to p15-cell cycle G1/S

N00089

Amplified MYC to cell cycle G1/S

N00090

p15-Cell cycle G1/S

N00091

p27-Cell cycle G1/S

N00092

Amplified MYC to p27-cell cycle G1/S

N00093

Loss of CDKN1B to p27-cell cycle G1/S

N00168

KSHV vCyclin to cell cycle G1/S

N00170

KSHV LANA to cell cycle G1/S

N00254

CDKN1B-reduced expression to p27-cell cycle G1/S

N00255

Amplified CCNE to cell cycle G1/S

N00264

EBV EBNA3C to p27-Cell cycle G1/S

N00275

Amplified CCND1 to cell cycle G1/S

N00316

Mutation-inactivated CDKN1B to p27-cell cycle G1/S

N00347

p300-p21-Cell cycle G1/S

N00360

HPV E7 to p27-cell cycle G1/S

N00361

HPV E7 to cell cycle G1/S

N00422

HCMV IE2-86 to cell cycle G1/S

N00423

HCMV IE1-72 to cell cycle G1/S

N00424

HCMV pp71 to cell cycle G1/S

N00482

EBV EBNA3C to p27-Cell cycle G1/S

N00483

EBV EBNA3C to cell cycle G1/S

N00484

EBV EBNA3C to cell cycle G1/S

N00497

HTLV-1 Tax to p21-cell cycle G1/S

N00498

HTLV-1 Tax to p21-cell cycle G1/S

N00536

MDM2-p21-Cell cycle G1/S

N00537

HBV HBx to cell cycle G1/S

N01336

CHRNA7-E2F signaling pathway

N01337

NNK/NNN to CHRNA7-E2F signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    1869 (E2F1)
  09143 Cell growth and death
   04110 Cell cycle
    1869 (E2F1)
   04218 Cellular senescence
    1869 (E2F1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1869 (E2F1)
   05206 MicroRNAs in cancer
    1869 (E2F1)
   05207 Chemical carcinogenesis - receptor activation
    1869 (E2F1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1869 (E2F1)
   05225 Hepatocellular carcinoma
    1869 (E2F1)
   05226 Gastric cancer
    1869 (E2F1)
   05214 Glioma
    1869 (E2F1)
   05220 Chronic myeloid leukemia
    1869 (E2F1)
   05218 Melanoma
    1869 (E2F1)
   05219 Bladder cancer
    1869 (E2F1)
   05215 Prostate cancer
    1869 (E2F1)
   05224 Breast cancer
    1869 (E2F1)
   05222 Small cell lung cancer
    1869 (E2F1)
   05223 Non-small cell lung cancer
    1869 (E2F1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1869 (E2F1)
   05161 Hepatitis B
    1869 (E2F1)
   05160 Hepatitis C
    1869 (E2F1)
   05163 Human cytomegalovirus infection
    1869 (E2F1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1869 (E2F1)
   05169 Epstein-Barr virus infection
    1869 (E2F1)
   05165 Human papillomavirus infection
    1869 (E2F1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1869 (E2F1)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1869 (E2F1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1869 (E2F1)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1869 (E2F1)

SSDB

Motif

Pfam:

E2F_CC-MB E2F_TDP TP1

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

20:complement(33675477..33686385)

AA seq 437 aa
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD
PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK
SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI
AKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS
QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPE
ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS
RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG
IRDLFDCDFGDLTPLDF

NT seq 1314 nt +upstreamnt +downstreamnt
atggccttggccggggcccctgcgggcggcccatgcgcgccggcgctggaggccctgctc
ggggccggcgcgctgcggctgctcgactcctcgcagatcgtcatcatctccgccgcgcag
gacgccagcgccccgccggctcccaccggccccgcggcgcccgccgccggcccctgcgac
cctgacctgctgctcttcgccacaccgcaggcgccccggcccacacccagtgcgccgcgg
cccgcgctcggccgcccgccggtgaagcggaggctggacctggaaactgaccatcagtac
ctggccgagagcagtgggccagctcggggcagaggccgccatccaggaaaaggtgtgaaa
tccccgggggagaagtcacgctatgagacctcactgaatctgaccaccaagcgcttcctg
gagctgctgagccactcggctgacggtgtcgtcgacctgaactgggctgccgaggtgctg
aaggtgcagaagcggcgcatctatgacatcaccaacgtccttgagggcatccagctcatt
gccaagaagtccaagaaccacatccagtggctgggcagccacaccacagtgggcgtcggc
ggacggcttgaggggttgacccaggacctccgacagctgcaggagagcgagcagcagctg
gaccacctgatgaatatctgtactacgcagctgcgcctgctctccgaggacactgacagc
cagcgcctggcctacgtgacgtgtcaggaccttcgtagcattgcagaccctgcagagcag
atggttatggtgatcaaagcccctcctgagacccagctccaagccgtggactcttcggag
aactttcagatctcccttaagagcaaacaaggcccgatcgatgttttcctgtgccctgag
gagaccgtaggtgggatcagccctgggaagaccccatcccaggaggtcacttctgaggag
gagaacagggccactgactctgccaccatagtgtcaccaccaccatcatctcccccctca
tccctcaccacagatcccagccagtctctactcagcctggagcaagaaccgctgttgtcc
cggatgggcagcctgcgggctcccgtggacgaggaccgcctgtccccgctggtggcggcc
gactcgctcctggagcatgtgcgggaggacttctccggcctcctccctgaggagttcatc
agcctttccccaccccacgaggccctcgactaccacttcggcctcgaggagggcgagggc
atcagagacctcttcgactgtgactttggggacctcacccccctggatttctga

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