KEGG   Homo sapiens (human): 192670
Entry
192670            CDS       T01001                                 
Symbol
AGO4, EIF2C4
Name
(RefSeq) argonaute RISC component 4
  KO
K11593  eukaryotic translation initiation factor 2C
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    192670 (AGO4)
   03036 Chromosome and associated proteins [BR:hsa03036]
    192670 (AGO4)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     192670 (AGO4)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Gene silencing
   RISC (RNA-induced silencing complex)
    192670 (AGO4)
   RNA interference (RNAi) pathway
    RITS (RNA-induced transcriptional silencing) complex
     192670 (AGO4)
   microRNA pathway
    RISC loading complex
     192670 (AGO4)
SSDB
Motif
Pfam: Piwi ArgoMid PAZ ArgoN ArgoL1 ArgoL2
Other DBs
NCBI-GeneID: 192670
NCBI-ProteinID: NP_060099
OMIM: 607356
HGNC: 18424
Ensembl: ENSG00000134698
UniProt: Q9HCK5
Structure
Position
1:35807636..35857890
AA seq 861 aa
MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRV
NREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKV
SVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYH
PLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPL
TDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ
YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR
SAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVA
TPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQ
PCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQ
VKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK
PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR
FKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCA
DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE
LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRD
PQALAKAVQIHHDTQHTMYFA
NT seq 2586 nt   +upstreamnt  +downstreamnt
atggaggcgctgggacccggacctccggctagcctgtttcagccacctcgtcgtcctggc
cttggaactgttggaaaaccaattcgactgttagccaatcattttcaggttcagattcct
aaaatagatgtgtatcactatgatgtggatattaagcctgaaaaacggcctcgtagagtc
aacagggaggtagtagatacaatggtgcggcacttcaagatgcaaatatttggtgatcgg
cagcctgggtatgatggcaaaagaaacatgtacacagcacatccactaccaattggacgg
gatagggttgatatggaggtgactcttccaggcgagggtaaagaccaaacatttaaagtg
tctgttcagtgggtgtcagttgtgagccttcagttgcttttagaagctttggctgggcac
ttgaatgaagtcccagatgactcagtacaagcacttgatgttatcacaagacaccttccc
tccatgaggtacaccccagtgggccgttcctttttctcacccccggaaggttactaccac
cctctgggagggggcagggaggtctggtttggttttcatcagtctgtgagacctgccatg
tggaatatgatgctcaacattgatgtatctgcaactgctttctaccgggctcagcctatc
attgagttcatgtgtgaggttttagacattcagaacatcaatgaacagaccaaacctcta
acagactcccagcgtgtcaaatttaccaaagaaatcagaggtctcaaagttgaggtgacc
cactgtggacagatgaaacgaaaataccgagtttgtaatgtgactagacggccagccagt
catcaaacttttcctttgcagctagaaaacggtcaagctatggaatgtacagtagctcaa
tattttaagcaaaagtatagtctgcaactgaaatacccccatcttccctgtctccaagtg
ggacaagaacaaaagcatacatacttgccactcgaggtctgtaatatagtggcaggacag
cgatgtatcaagaagctcacagacaatcagacttccacaatgatcaaagctacagcaaga
tctgctcctgacagacaggaagagatcagtagactggtgaagagcaacagtatggtgggt
ggacctgatccataccttaaagaatttggtattgttgtccacaatgaaatgacagagctc
acaggcagggtacttccagcaccaatgctgcaatatggaggccggaataaaacagtagcc
acacccaaccagggtgtctgggacatgcgaggaaagcagttttatgctggcattgaaatt
aaagtttgggcagttgcttgttttgcacctcagaaacaatgtagggaagatttactaaag
agtttcactgaccagctgcgtaaaatctctaaggatgcaggaatgcccatccagggtcag
ccatgtttctgcaagtatgcacaaggtgcagacagtgtggagcctatgtttaaacatctg
aaaatgacttatgtgggcctacagctaatagtggttatcctgcctggaaagacaccagta
tatgcggaggtgaaacgtgttggagatacccttctaggtatggccacacagtgtgtccag
gtaaaaaatgtagtgaagacctcacctcaaaccctttccaatctttgcctgaagataaat
gcaaaacttggaggaattaacaatgtgcttgtgcctcatcaaaggccctcggtgttccag
cagcctgtcatcttcctgggagcggatgtcacacaccccccagcaggggatgggaagaaa
ccttccattgctgctgtggttggcagtatggatggccaccccagccggtactgtgccacc
gttcgggtgcagacttcccggcaggagatctcccaagagctcctctacagtcaagaggtc
atccaggacctgactaacatggttcgagagctgctgattcagttctacaaatccacacgc
ttcaaacccactcggatcatctattaccgtggaggggtatctgagggacaaatgaaacag
gtagcttggccagaactaatagcaattcgaaaggcatgtattagcttggaagaagattac
cggccaggaataacttatattgtggtgcaaaaaagacatcacacacgactcttctgtgca
gataaaacagaaagggtagggaaaagtggcaatgtaccagcaggcactacagtggatagt
accatcacacatccatctgagtttgacttttacctctgtagtcatgcaggaattcaggga
accagccgtccctcacattaccaggtcttgtgggatgacaactgcttcactgcagatgaa
ctccagctactgacttaccagctgtgtcacacctatgtgaggtgcactcgctcagtctct
attccagcccctgcatattatgcccggcttgtagcatttagggcaaggtatcatctggtg
gataaagatcatgacagtgcggaaggcagtcatgtgtcaggacagagcaacggccgggat
cctcaggccttggctaaggctgtgcaaatccaccatgatacccagcacacgatgtatttt
gcctga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (34)   
   RefSeq(nuc) (22)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   Pfam (6)   
All databases (82)   

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