KEGG   Homo sapiens (human): 1954
Entry
1954              CDS       T01001                                 
Symbol
MEGF8, C19orf49, CRPT2, EGFL4, SBP1
Name
(RefSeq) multiple EGF like domains 8
  KO
K23664  multipile epidermal growth factor-like domains protein 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
Network
nt06535  Efferocytosis
  Element
N01749  Find-me signal (CX3CL1)
Disease
H01888  Carpenter syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    1954 (MEGF8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    1954 (MEGF8)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 Laminin domain-containing proteins
  Laminin EGF-like domain-containing proteins
   1954 (MEGF8)
SSDB
Motif
Pfam: Kelch_3 Kelch_4 Kelch_5 Kelch_1 Kelch_6 CUB Laminin_EGF EGF_3 EGF_CA PSI PSI_integrin EGF_2 hEGF EGF DL-JAG_EGF-like
Other DBs
NCBI-GeneID: 1954
NCBI-ProteinID: NP_001258867
OMIM: 604267
HGNC: 3233
Ensembl: ENSG00000105429
UniProt: Q7Z7M0
Position
19:42325635..42378765
AA seq 2845 aa
MALGKVLAMALVLALAVLGSLSPGARAGDCKGQRQVLREAPGFVTDGAGNYSVNGNCEWL
IEAPSPQHRILLDFLFLDTECTYDYLFVYDGDSPRGPLLASLSGSTRPPPIEASSGKMLL
HLFSDANYNLLGFNASFRFSLCPGGCQSHGQCQPPGVCACEPGWGGPDCGLQECSAYCGS
HGTCASPLGPCRCEPGFLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPG
LLAVFGGQDLNNALGDLVLYNFSANTWESWDLSPAPAARHSHVAVAWAGSLVLMGGELAD
GSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFS
SGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGHRPSTARFSVRV
NSTELFHVDRHVWTTLKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDG
IFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSGRPRGDL
MAYKVPPFVFQAPAPDYHLDYCSMYTDHSVCSRDPECSWCQGACQAAPPPGTPLGACPAA
SCLGLGRLLGDCQACLAFSSPTAPPRGPGTLGWCVHNESCLPRPEQARCRGEQISGTVGW
WGPAPVFVTSLEACVTQSFLPGLHLLTFQQPPNTSQPDKVSIVRSTTITLTPSAETDVSL
VYRGFIYPMLPGGPGGPGAEDVAVWTRAQRLHVLARMARGPDTENMEEVGRWVAHQEKET
RRLQRPGSARLFPLPGRDHKYAVEIQGQLNGSAGPGHSELTLLWDRTGVPGGSEISFFFL
EPYRSSSCTSYSSCLGCLADQGCGWCLTSATCHLRQGGAHCGDDGAGGSLLVLVPTLCPL
CEEHRDCHACTQDPFCEWHQSTSRKGDAACSRRGRGRGALKSPEECPPLCSQRLTCEDCL
ANSSQCAWCQSTHTCFLFAAYLARYPHGGCRGWDDSVHSEPRCRSCDGFLTCHECLQSHE
CGWCGNEDNPTLGRCLQGDFSGPLGGGNCSLWVGEGLGLPVALPARWAYARCPDVDECRL
GLARCHPRATCLNTPLSYECHCQRGYQGDGISHCNRTCLEDCGHGVCSGPPDFTCVCDLG
WTSDLPPPTPAPGPPAPRCSRDCGCSFHSHCRKRGPGFCDECQDWTWGEHCERCRPGSFG
NATGSRGCRPCQCNGHGDPRRGHCDNLSGLCFCQDHTEGAHCQLCSPGYYGDPRAGGSCF
RECGGRALLTNVSSVALGSRRVGGLLPPGGGAARAGPGLSYCVWVVSATEELQPCAPGTL
CPPLTLTFSPDSSTPCTLSYVLAFDGFPRFLDTGVVQSDRSLIAAFCGQRRDRPLTVQAL
SGLLVLHWEANGSSSWGFNASVGSARCGSGGPGSCPVPQECVPQDGAAGAGLCRCPQGWA
GPHCRMALCPENCNAHTGAGTCNQSLGVCICAEGFGGPDCATKLDGGQLVWETLMDSRLS
ADTASRFLHRLGHTMVDGPDATLWMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAEDGG
PGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFWVLNLTTLQWRQEKAPQTVELPAV
AGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYH
EATDSLYVFGGFRFHVELAAPSPELYSLHCPDRTWSLLAPSQGAKRDRMRNVRGSSRGLG
QVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVL
GGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGGFG
GVALGRLLALTLPPDPCRLLSSPEACNQSGACTWCHGACLSGDQAHRLGCGGSPCSPMPR
SPEECRRLRTCSECLARHPRTLQPGDGEASTPRCKWCTNCPEGACIGRNGSCTSENDCRI
NQREVFWAGNCSEAACGAADCEQCTREGKCMWTRQFKRTGETRRILSVQPTYDWTCFSHS
LLNVSPMPVESSPPLPCPTPCHLLPNCTSCLDSKGADGGWQHCVWSSSLQQCLSPSYLPL
RCMAGGCGRLLRGPESCSLGCAQATQCALCLRRPHCGWCAWGGQDGGGRCMEGGLSGPRD
GLTCGRPGASWAFLSCPPEDECANGHHDCNETQNCHDQPHGYECSCKTGYTMDNMTGLCR
PVCAQGCVNGSCVEPDHCRCHFGFVGRNCSTECRCNRHSECAGVGARDHCLLCRNHTKGS
HCEQCLPLFVGSAVGGGTCRPCHAFCRGNSHICISRKELQMSKGEPKKYSLDPEEIENWV
TEGPSEDEAVCVNCQNNSYGEKCESCLQGYFLLDGKCTKCQCNGHADTCNEQDGTGCPCQ
NNTETGTCQGSSPSDRRDCYKYQCAKCRESFHGSPLGGQQCYRLISVEQECCLDPTSQTN
CFHEPKRRALGPGRTVLFGVQPKFTNVDIRLTLDVTFGAVDLYVSTSYDTFVVRVAPDTG
VHTVHIQPPPAPPPPPPPADGGPRGAGDPGGAGASSGPGAPAEPRVREVWPRGLITYVTV
TEPSAVLVVRGVRDRLVITYPHEHHALKSSRFYLLLLGVGDPSGPGANGSADSQGLLFFR
QDQAHIDLFVFFSVFFSCFFLFLSLCVLLWKAKQALDQRQEQRRHLQEMTKMASRPFAKV
TVCFPPDPTAPASAWKPAGLPPPAFRRSEPFLAPLLLTGAGGPWGPMGGGCCPPAIPATT
AGLRAGPITLEPTEDGMAGVATLLLQLPGGPHAPNGACLGSALVTLRHRLHEYCGGGGGA
GGSGHGTGAGRKGLLSQDNLTSMSL
NT seq 8538 nt   +upstreamnt  +downstreamnt
atggccctgggcaaggttctggccatggcactggttttggccttggccgtgctggggtcg
ctgtcccctggggcccgggcgggggactgcaaggggcagcggcaggtgctgcgggaggcg
ccaggcttcgtgacggatggtgcgggcaactacagcgtcaatggcaactgcgagtggctc
atcgaggccccaagcccccagcaccggatcctgctggacttccttttcctggacacagag
tgcacgtatgactacctgttcgtgtatgacggtgactccccgcgagggccgctgcttgcc
agtctaagtgggagcacccgacctccgcccatcgaagcttcctcaggcaagatgctgctg
cacctcttcagtgatgccaactacaacctgctgggctttaacgcctcattccgcttctcc
ctgtgcccgggtggctgccagagccacgggcagtgccagccaccgggtgtgtgtgcctgc
gagccgggctgggggggtcctgactgtggcctgcaggagtgctcagcctactgtggcagc
cacggcacctgcgcctcgcccctgggaccatgccgctgtgagcctggcttcttgggacgt
gcctgtgacctgcacctgtgggagaaccagggggctgggtggtggcacaacgtgagtgcc
agggaccctgccttctctgcccgtattggggcagctggcgccttcctgtccccaccaggg
ctgctggcagttttcggaggccaggacctcaacaatgccctgggtgacctcgtcctatac
aacttctccgccaacacctgggagtcttgggacctgagtcctgccccggctgcccgtcac
tcccatgtggccgtggcctgggccggctccctggtactgatgggtggtgagctggctgac
ggctcgctcaccaacgacgtgtgggccttcagtccactgggcaggggccactgggagctc
ctggcaccacctgcctccagctcctcggggcccccaggcctggcaggtcacgcggctgcc
ctggtggatgatgtctggctatatgtgtctggaggccgcaccccgcacgacctcttctcc
tctggcctcttccgtttccgccttgacagcaccagcgggggctattgggagcaggtgatt
ccggcaggcggacggccccctgctgccactggccactccatggtgttccatgccccctcc
cgtgccctgctggtccatggtggacaccggccctccactgcccggttctctgtgcgagtg
aactccactgagcttttccacgtggatcggcatgtgtggacgacgctgaaggggcgggat
gggcttcagggcccaagggagcgagccttccacacagccagtgttctgggcaattacatg
gtggtctatgggggcaatgtgcacacccattaccaggaggaaaagtgctacgaagatggc
atcttcttctaccaccttggctgccatcaatgggtgtcaggagctgagcttgccccgcca
ggaacccctgagggccgagcagcgcctcccagtggtcggtactcacatgtagctgcggtg
cttggtggcagcgtcctgttggtggctggggggtacagcggccggccccgtggggacttg
atggcgtacaaggtgcccccctttgtgttccaggcacctgcccctgactaccacttggac
tactgctccatgtacacagaccacagcgtctgctcccgggacccggaatgcagttggtgc
caaggagcctgccaagctgcaccccctcctgggacccccttgggggcttgtccagccgcc
agctgcctgggcctgggccgcctcctgggtgactgccaggcctgcctggccttcagcagc
cccacagcccctccacggggacctggcaccctgggctggtgcgtgcacaatgagagctgc
ctccctaggcctgagcaggcccgctgccgaggggagcagatctcaggcactgtgggctgg
tgggggcctgcgcctgtcttcgtcacgtccctggaggcctgcgtcacccagagcttcctg
cctggcctgcacttgctcacctttcagcagccgcccaatacctcccagcctgacaaggtc
tcaattgtccgcagcacgaccatcaccctaacacccagcgcagagacagatgtgtccctg
gtctaccgtggcttcatctacccaatgctgcctggagggccaggtggaccaggggctgag
gacgtggccgtgtggacgcgggcccagcgcctacacgtcctggcccggatggcccgtggc
cctgacacggagaacatggaggaggtggggcgctgggtggctcatcaggagaaggagacg
cggcggctgcagcgccctgggtctgctcgcctcttccctctgcctgggcgggaccacaag
tatgcagtagagatccagggccagctcaatggctcggcaggccctgggcacagcgagcta
actctgctgtgggatcggactggtgtgccaggaggcagcgagatctccttcttcttcctg
gagccctaccgctcgtcgtcctgcacctcctattcttcctgcctgggctgcttggcagac
cagggctgtggctggtgcctgaccagtgccacctgccacctgcgccagggcggagcccat
tgcggggatgacggggctggtgggtccctgctggtgctggtgcctaccctctgcccactc
tgcgaggagcatcgggactgccacgcctgcacccaggaccccttctgtgagtggcatcag
agcaccagccgcaaaggggacgcggcatgcagccggcggggccggggtcggggtgccctg
aagagtccagaggagtgtcccccgctctgcagccagcgactgacctgtgaggactgcctg
gccaactctagccagtgcgcctggtgccagtccacccacacctgcttcctgtttgctgcc
tacttggcccggtacccacacgggggctgtcgaggctgggacgacagtgtacactcggag
ccacggtgccggagctgcgatggcttcctgacctgccatgagtgtctgcagagccacgag
tgtggctggtgtggcaatgaggacaaccccacactgggacggtgcctacagggggacttc
tcagggcccctcggtgggggtaactgctccctgtgggtgggggagggcctggggcttccc
gtggccctccctgcccgctgggcatacgcccgctgtcctgacgtggatgagtgtcgcctg
ggcctggcccggtgccacccgcgggcgacctgcctgaacacgcccctcagctacgagtgt
cactgccagcggggctaccagggtgatggcatctcacactgcaaccgcacgtgcttggag
gactgtggccatggtgtgtgcagtggccccccggactttacctgcgtgtgtgacctaggc
tggacatcagacctgccccctcccacacccgccccgggtccgccagccccccgctgctcc
cgggactgtggctgcagcttccacagccactgccgcaagcggggccctggcttctgcgac
gagtgccaggactggacatggggggagcactgcgaacgatgccggcccggcagcttcggc
aacgccacaggctctaggggctgccggccctgccagtgcaacgggcacggggacccacgc
cgtggccactgcgacaacctcagtgggctctgcttctgccaggaccacaccgagggtgcc
cactgccagctctgctccccaggctattatggggatccccgggccggtggttcctgcttt
cgggagtgtgggggtcgcgccctcctcaccaacgtgtcctcagtggcactgggctcacgc
cgggtcggggggctgctgcctccaggtggcggggctgcaagagccgggcctggcctgtcc
tactgtgtgtgggttgtctcggccactgaggagctacagccctgtgctcccgggaccctc
tgtcccccactcaccctcaccttctcccccgacagcagcaccccctgcacgctgagctac
gtcctggcgtttgatggattcccacgcttcctggacactggtgttgtccagtcggaccgc
agcctcatagctgccttctgcggccagcgacgggacaggcccctcactgttcaggccctg
tctgggctgctcgtgctgcactgggaggccaatggctcctcatcctggggcttcaatgct
tcggtgggctctgcccgctgtgggtcagggggccccgggagctgtcccgtcccccaggaa
tgcgtgccccaggacggtgctgcaggtgcggggctctgccgatgtcctcagggctgggct
ggcccacactgccgcatggctctgtgtcctgagaactgcaatgcccacactggggcagga
acttgtaaccagagcctgggtgtgtgcatctgtgccgagggcttcgggggccccgactgc
gccaccaagctggatggcgggcagctggtctgggagaccctcatggacagccgcctctca
gccgacactgccagccgcttcctgcaccgcctgggccacaccatggtggatggacccgat
gccaccttgtggatgtttgggggcctgggcctgccccaggggctgctgggaaacctgtac
aggtactcagtgagtgagcggcggtggacacagatgctggcgggagccgaggacgggggc
ccaggcccatcgccccgctccttccatgcagccgcatatgtgcccgctggccgtggtgcc
atgtatctgctggggggacttaccgctggaggcgtcacccgtgatttctgggtcctcaac
ctcaccaccctgcaatggcggcaggagaaggccccccagaccgtggagctgccagccgtt
gctggtcacacccttactgcccgccgaggcctgtctctgctcctggtgggcggttactcc
ccggaaaatggcttcaaccagcagctgctggagtaccagctggcaaccggcacctgggtg
tcaggagcccagagtgggacaccccccacaggtctctatggtcactctgctgtctaccac
gaggccaccgactccctctacgtgtttggggggttccgattccatgtggagctggcggcc
ccatcccccgagctctactccctgcactgtcctgaccgcacctggagtctgctggcccct
tctcagggggcaaagcgagatcgtatgaggaatgtgcgtggctcatctcggggtctgggc
caagttcctggggagcagcctgggtcatgggggttccgggaagtcaggaagaagatggct
ctgtgggctgctcttgctggtacaggaggtttcctggaggaaatctcacctcacctgaag
gagccccgcccccggcttttccacgcctcagccctgttaggggacaccatggtggttctt
ggggggcgctcggaccctgacgagttcagcagcgacgttctgctctaccaggtcaactgc
aatgcctggcttctgcccgacctcacccgctcggcctctgtggggcccccaatggaggag
tctgtggcccatgctgtggcagcagtcgggagccgcctgtatatctctgggggtttcggg
ggagtggccctgggccgcctgctggcactgaccctgccccctgacccctgccgcctgctg
tcctcacctgaagcttgtaaccagtctggggcctgcacctggtgccatggggcctgcttg
tccggggatcaggcccacaggctgggctgcgggggctccccctgctccccaatgcctcgc
tccccggaggaatgtcgacgtctccggacctgcagtgagtgcctggcccgccatcctcgg
accctgcaacctggagatggagaggcgtccaccccccgctgtaagtggtgtaccaactgc
cccgaaggtgcttgcattggacgcaatgggtcctgcacctctgagaatgactgtcggatc
aaccagcgagaggtcttctgggcagggaactgctccgaggctgcgtgcggggctgctgac
tgcgagcagtgcacgcgggagggcaagtgcatgtggacgcggcagttcaagaggacaggg
gagacccgccgcatcctctccgtgcagcccacctatgactggacgtgcttcagccactct
ctgctgaatgtgtcccccatgccggtggaatcatcacccccactgccctgccccacccct
tgtcacctcctacccaactgtacctcctgcctggactctaagggagcagatgggggctgg
cagcactgtgtttggagcagcagcctgcagcagtgtctgagcccttcctacctgcccctg
cgatgtatggccggaggctgtgggcggctgctccggggacctgagagctgctccctgggc
tgtgctcaggcaactcagtgcgccttgtgcctgcggcgcccccattgcggctggtgtgcc
tgggggggccaggatgggggtggccgctgcatggagggtggactcagcggcccccgtgat
gggctgacatgtgggcgtccgggggcctcctgggccttcctgtcctgcccccctgaggac
gagtgtgcaaacgggcaccacgactgcaacgagacgcagaattgccacgaccagccccac
ggctatgagtgcagctgcaagaccggctataccatggacaacatgacagggctgtgccgc
cctgtgtgcgcccagggctgcgtgaacggctcatgtgtggagcccgaccactgccgctgc
cactttggctttgtgggccgcaactgctccacggaatgccgctgcaaccgccacagtgaa
tgcgctggtgttggggcgcgtgaccactgcttgctctgccgcaaccacaccaagggcagc
cactgtgagcagtgcctcccgctgtttgtgggttcagctgtcggaggcgggacctgccgg
ccctgccacgccttttgtcgtggaaatagccacatctgcatctccaggaaggagttacaa
atgtccaagggagagccaaagaagtactcactggacccagaggagattgaaaactgggtg
acagagggtcctagtgaagacgaggccgtgtgcgtgaactgccagaataacagctatggg
gagaaatgcgagagctgcctgcagggctacttcctcctggacgggaagtgcaccaaatgc
cagtgtaatggccacgcggacacatgtaacgagcaggatgggacgggctgtccatgtcag
aataacacagagacgggcacatgccagggcagctcccccagtgaccgtcgagactgctac
aagtaccagtgcgccaagtgccgggaatcatttcacgggagtccgctgggcggccagcag
tgctaccgcctcatctcggtggagcaggagtgctgcctggaccccacgtcccagaccaac
tgcttccatgagcccaaacgccgggcgctaggccccggccgcactgtcctctttggcgtg
cagcccaaattcaccaacgtggacatccgcctgacgctggacgtgaccttcggggccgtg
gacctctatgtctccacctcctatgacaccttcgtggtccgtgtggcccctgacactggc
gtccatactgtacacatccagccacccccagccccaccacctccaccaccccctgcagat
ggtgggccccggggggctggggatccaggaggagcaggggccagcagtgggccgggcgcc
ccagcagagccacgggtacgggaggtatggccgcggggcctgattacctacgtgacggtg
acggagccgtcggcagtgctggtggtccgcggcgtgcgggaccggctggtcatcacctac
ccacacgagcaccatgccctcaagtcgagccgcttctacctgctgctgctgggcgtggga
gacccaagtgggcccggcgccaacggctcagccgactcgcagggcctgctcttcttccgg
caggaccaggcccacattgacctgtttgtcttcttctccgtcttcttctcctgcttcttc
ctcttcctctcactctgtgtgctcctctggaaggccaagcaggctctggaccagcggcag
gagcagcgccggcacttgcaggagatgaccaagatggccagccgccccttcgccaaggtc
accgtctgcttcccacctgaccctactgccccggcctccgcctggaagccggctgggctc
ccacctcccgccttccgccgctctgagcccttcctggcacccctgctgctgacaggggcc
ggtgggccctggggacccatgggagggggctgctgcccaccagccatccccgccaccact
gctgggctgcgagctgggcccatcactctcgagcccacagaagatggcatggctggcgtg
gccacactgctgctccagctgcctggcgggccccatgcacccaacggcgcctgcctgggg
tcagccctcgtcacactgcggcacaggctgcacgagtactgtgggggtggtgggggtgct
gggggcagtgggcatgggactggtgcgggccggaagggactgttgagccaggacaacctc
accagcatgtccctctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (123)   
   KEGG ORTHOLOGY (1)   
   RefGene (117)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (23)   
   RefSeq(nuc) (3)   
   GenBank (10)   
   EMBL (10)   
Protein domain (15)   
   Pfam (15)   
All databases (174)   

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