KEGG   Homo sapiens (human): 1981
Entry
1981              CDS       T01001                                 
Symbol
EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
Name
(RefSeq) eukaryotic translation initiation factor 4 gamma 1
  KO
K03260  translation initiation factor 4G
Organism
hsa  Homo sapiens (human)
Pathway
hsa05416  Viral myocarditis
Disease
H00057  Parkinson disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09166 Cardiovascular disease
   05416 Viral myocarditis
    1981 (EIF4G1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1981 (EIF4G1)
   03012 Translation factors [BR:hsa03012]
    1981 (EIF4G1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     1981 (EIF4G1)
   mRNA cycle factors
    Stress granule specific factors
     1981 (EIF4G1)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-4
    1981 (EIF4G1)
SSDB
Motif
Pfam: MIF4G MA3 W2 eIF4G1-like_eIF4E-bd RabGAP-TBC
Other DBs
NCBI-GeneID: 1981
NCBI-ProteinID: NP_937884
OMIM: 600495
HGNC: 3296
Ensembl: ENSG00000114867
UniProt: Q04637 Q96I65
Structure
Position
3:184314606..184335358
AA seq 1599 aa
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS
SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI
IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE
PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ
WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM
KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR
KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN
QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV
QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV
VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ
PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK
EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY
EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL
GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS
EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD
VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF
YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
NT seq 4800 nt   +upstreamnt  +downstreamnt
atgaacaaagctccacagtccacaggccccccacccgccccatcccccggactcccacag
ccagcgtttcccccggggcagacagcgccggtggtgttcagtacgccacaagcgacacaa
atgaacacgccttctcagccccgccagcacttctaccctagccgggcccagcccccgagc
agtgcagcctcccgagtgcagagtgcagcccctgcccgccctggcccagctgcccatgtc
taccctgctggatcccaagtaatgatgatcccttcccagatctcctacccagcctcccag
ggggcctactacatccctggacaggggcgttccacatacgttgtcccgacacagcagtac
cctgtgcagccaggagccccaggcttctatccaggtgcaagccctacagaatttgggacc
tacgctggcgcctactatccagcccaaggggtgcagcagtttcccactggcgtggccccc
accccagttttgatgaaccagccaccccagattgctcccaagagggagcgtaagacgatc
cgaattcgagatccaaaccaaggaggaaaggatatcacagaggagatcatgtctggggcc
cgcactgcctccacacccacccctccccagacgggaggcggtctggagcctcaagctaat
ggggagacgccccaggttgctgtcattgtccggccagatgaccggtcacagggagcaatc
attgctgaccggccagggctgcctggcccagagcatagcccttcagaatcccagccttcg
tcgccttctccgaccccatcaccatccccagtcttggaaccggggtctgagcctaatctc
gcagtcctctctattcctggggacactatgacaactatacaaatgtctgtagaagaatca
acccccatctcccgtgaaactggggagccatatcgcctctctccagaacccactcctctc
gccgaacccatactggaagtagaagtgacacttagcaaaccggttccagaatctgagttt
tcttccagtcctctccaggctcccacccctttggcatctcacacagtggaaattcatgag
cctaatggcatggtcccatctgaagatctggaaccagaggtggagtcaagcccagagctt
gctcctcccccagcttgcccctccgaatcccctgtgcccattgctccaactgcccaacct
gaggaactgctcaacggagccccctcgccaccagctgtggacttaagcccagtcagtgag
ccagaggagcaggccaaggaggtgacagcatcaatggcgccccccaccatcccctctgct
actccagctacggctccttcagctacttccccagctcaggaggaggaaatggaagaagaa
gaagaagaggaagaaggagaagcaggagaagcaggagaagctgagagtgagaaaggagga
gaggaactgctccccccagagagtacccctattccagccaacttgtctcagaatttggag
gcagcagcagccactcaagtggcagtatctgtgccaaagaggagacggaaaattaaggag
ctaaataagaaggaggctgttggagaccttctggatgccttcaaggaggcgaacccggca
gtaccagaggtggaaaatcagcctcctgcaggcagcaatccaggcccagagtctgagggc
agtggtgtgcccccacgtcctgaggaagcagatgagacctgggactcaaaggaagacaaa
attcacaatgctgagaacatccagcccggggaacagaagtatgaatataagtcagatcag
tggaagcctctaaacctagaggagaaaaaacgttacgaccgtgagttcctgcttggtttt
cagttcatctttgccagtatgcagaagccagagggattgccacatatcagtgacgtggtg
ctggacaaggccaataaaacaccactgcggccactggatcccactagactacaaggcata
aattgtggcccagacttcactccatcctttgccaaccttggccggacaacccttagcacc
cgtgggcccccaaggggtgggccaggtggggagctgccccgtgggccggctggcctggga
ccccggcgctctcagcagggaccccgaaaagaaccacgcaagatcattgccacagtgtta
atgaccgaagatataaaactgaacaaagcagagaaagcctggaaacccagcagcaagcgg
acggcggctgataaggatcgaggggaagaagatgctgatggcagcaaaacccaggaccta
ttccgcagggtgcgctccatcctgaataaactgacaccccagatgttccagcagctgatg
aagcaagtgacgcagctggccatcgacaccgaggaacgcctcaaaggggtcattgacctc
atttttgagaaggccatttcagagcccaacttctctgtggcctatgccaacatgtgccgc
tgcctcatggcgctgaaagtgcccactacggaaaagccaacagtgactgtgaacttccga
aagctgttgttgaatcgatgtcagaaggagtttgagaaagacaaagatgatgatgaggtt
tttgagaagaagcaaaaagagatggatgaagctgctacggcagaggaacgaggacgcctg
aaggaagagctggaagaggctcgggacatagcccggcggcgctctttagggaatatcaag
tttattggagagttgttcaaactgaagatgttaacagaggcaataatgcatgactgtgtg
gtcaaactgcttaagaaccatgatgaagagtcccttgagtgcctttgtcgtctgctcacc
accattggcaaagacctggactttgaaaaagccaagccccgaatggatcagtatttcaac
cagatggaaaaaatcattaaagaaaagaagacgtcatcccgcatccgctttatgctgcag
gacgtgctggatctgcgagggagcaattgggtgccacgccgaggggatcagggtcccaag
accattgaccagatccataaggaggctgagatggaagaacatcgagagcacatcaaagtg
cagcagctcatggccaagggcagtgacaagcgtcggggcggtcctccaggccctcccatc
agccgtggacttccccttgtggatgatggtggctggaacacagttcccatcagcaaaggt
agccgccccattgacacctcacgactcaccaagatcaccaagcctggctccatcgattct
aacaaccagctctttgcacctggagggcgactgagctggggcaagggcagcagcggaggc
tcaggagccaagccctcagacgcagcatcagaagctgctcgcccagctactagtactttg
aatcgcttctcagcccttcaacaagcggtacccacagaaagcacagataatagacgtgtg
gtgcagaggagtagcttgagccgagaacgaggcgagaaagctggagaccgaggagaccgc
ctagagcggagtgaacggggaggggaccgtggggaccggcttgatcgtgcgcggacacct
gctaccaagcggagcttcagcaaggaagtggaggagcggagtagagaacggccctcccag
cctgaggggctgcgcaaggcagctagcctcacggaggatcgggaccgtgggcgggatgcc
gtgaagcgagaagctgccctacccccagtgagccccctgaaggcggctctctctgaggag
gagttagagaagaaatccaaggctatcattgaggaatatctccatctcaatgacatgaaa
gaggcagtccagtgcgtgcaggagctggcctcaccctccttgctcttcatctttgtacgg
catggtgtcgagtctacgctggagcgcagtgccattgctcgtgagcatatggggcagctg
ctgcaccagctgctctgtgctgggcatctgtctactgctcagtactaccaagggttgtat
gaaatcttggaattggctgaggacatggaaattgacatcccccacgtgtggctctaccta
gcggaactggtaacacccattctgcaggaaggtggggtgcccatgggggagctgttcagg
gagattacaaagcctctgagaccgttgggcaaagctgcttccctgttgctggagatcctg
ggcctcctgtgcaaaagcatgggtcctaaaaaggtggggacgctgtggcgagaagccggg
cttagctggaaggaatttctacctgaaggccaggacattggtgcattcgtcgctgaacag
aaggtggagtataccctgggagaggagtcggaagcccctggccagagggcactcccctcc
gaggagctgaacaggcagctggagaagctgctgaaggagggcagcagtaaccagcgggtg
ttcgactggatagaggccaacctgagtgagcagcagatagtatccaacacgttagttcga
gccctcatgacggctgtctgctattctgcaattatttttgagactcccctccgagtggac
gttgcagtgctgaaagcgcgagcgaagctgctgcagaaatacctgtgtgacgagcagaag
gagctacaggcgctctacgccctccaggcccttgtagtgaccttagaacagcctcccaac
ctgctgcggatgttctttgacgcactgtatgacgaggacgtggtgaaggaggatgccttc
tacagttgggagagtagcaaggaccccgctgagcagcagggcaagggtgtggcccttaaa
tctgtcacagccttcttcaagtggctccgtgaagcagaggaggagtctgaccacaactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (80)   
   RefSeq(nuc) (8)   
   GenBank (36)   
   EMBL (36)   
3D Structure (13)   
   PDB (13)   
Protein domain (5)   
   Pfam (5)   
All databases (150)   

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