KEGG   Homo sapiens (human): 2043
Entry
2043              CDS       T01001                                 
Symbol
EPHA4, EK8, HEK8, SEK, TYRO1
Name
(RefSeq) EPH receptor A4
  KO
K05105  Eph receptor A4 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Network
nt06511  NOTCH signaling
  Element
N01481  Notch-MESP2 signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    2043 (EPHA4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2043 (EPHA4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2043 (EPHA4)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  EPH family [OT]
   2043 (EPHA4)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Ephrin_lbd Pkinase fn3 EphA2_TM SAM_2 SAM_1 Pur_ac_phosph_N Ephrin_rec_like fn3_2 CRLF2-like_D2 ABC1 Kdo Haspin_kinase DUF6479 DUF6377 TM_ErbB1
Other DBs
NCBI-GeneID: 2043
NCBI-ProteinID: NP_001291465
OMIM: 602188
HGNC: 3388
Ensembl: ENSG00000116106
UniProt: P54764
Structure
Position
2:complement(221418027..221574202)
AA seq 986 aa
MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIM
DEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKE
TFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK
DVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSV
WEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDI
SYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVS
KYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYE
KDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRII
GDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPF
TYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT
DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTV
IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT
TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG
YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNT
ALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAIT
HQNKILSSVQAMRTQMQQMHGRMVPV
NT seq 2961 nt   +upstreamnt  +downstreamnt
atggctgggattttctatttcgccctattttcgtgtctcttcgggatttgcgacgctgtc
acaggttccagggtataccccgcgaatgaagttaccttattggattccagatctgttcag
ggagaacttgggtggatagcaagccctctggaaggagggtgggaggaagtgagtatcatg
gatgaaaaaaatacaccaatccgaacctaccaagtgtgcaatgtgatggaacccagccag
aataactggctacgaactgattggatcacccgagaaggggctcagagggtgtatattgag
attaaattcaccttgagggactgcaatagtcttccgggcgtcatggggacttgcaaggag
acgtttaacctgtactactatgaatcagacaacgacaaagagcgtttcatcagagagaac
cagtttgtcaaaattgacaccattgctgctgatgagagcttcacccaagtggacattggt
gacagaatcatgaagctgaacaccgagatccgggatgtagggccattaagcaaaaagggg
ttttacctggcttttcaggatgtgggggcctgcatcgccctggtatcagtccgtgtgttc
tataaaaagtgtccactcacagtccgcaatctggcccagtttcctgacaccatcacaggg
gctgatacgtcttccctggtggaagttcgaggctcctgtgtcaacaactcagaagagaaa
gatgtgccaaaaatgtactgtggggcagatggtgaatggctggtacccattggcaactgc
ctatgcaacgctgggcatgaggagcggagcggagaatgccaagcttgcaaaattggatat
tacaaggctctctccacggatgccacctgtgccaagtgcccaccccacagctactctgtc
tgggaaggagccacctcgtgcacctgtgaccgaggctttttcagagctgacaacgatgct
gcctctatgccctgcacccgtccaccatctgctcccctgaacttgatttcaaatgtcaac
gagacatctgtgaacttggaatggagtagccctcagaatacaggtggccgccaggacatt
tcctataatgtggtatgcaagaaatgtggagctggtgaccccagcaagtgccgaccctgt
ggaagtggggtccactacaccccacagcagaatggcttgaagaccaccaaagtctccatc
actgacctcctagctcataccaattacacctttgaaatctgggctgtgaatggagtgtcc
aaatataaccctaacccagaccaatcagtttctgtcactgtgaccaccaaccaagcagca
ccatcatccattgctttggtccaggctaaagaagtcacaagatacagtgtggcactggct
tggctggaaccagatcggcccaatggggtaatcctggaatatgaagtcaagtattatgag
aaggatcagaatgagcgaagctatcgtatagttcggacagctgccaggaacacagatatc
aaaggcctgaaccctctcacttcctatgttttccacgtgcgagccaggacagcagctggc
tatggagacttcagtgagcccttggaggttacaaccaacacagtgccttcccggatcatt
ggagatggggctaactccacagtccttctggtctctgtctcgggcagtgtggtgctggtg
gtaattctcattgcagcttttgtcatcagccggagacggagtaaatacagtaaagccaaa
caagaagcggatgaagagaaacatttgaatcaaggtgtaagaacatatgtggaccccttt
acgtacgaagatcccaaccaagcagtgcgagagtttgccaaagaaattgacgcatcctgc
attaagattgaaaaagttataggagttggtgaatttggtgaggtatgcagtgggcgtctc
aaagtgcctggcaagagagagatctgtgtggctatcaagactctgaaagctggttataca
gacaaacagaggagagacttcctgagtgaggccagcatcatgggacagtttgaccatccg
aacatcattcacttggaaggcgtggtcactaaatgtaaaccagtaatgatcataacagag
tacatggagaatggctccttggatgcattcctcaggaaaaatgatggcagatttacagtc
attcagctggtgggcatgcttcgtggcattgggtctgggatgaagtatttatctgatatg
agctatgtgcatcgtgatctggccgcacggaacatcctggtgaacagcaacttggtctgc
aaagtgtctgattttggcatgtcccgagtgcttgaggatgatccggaagcagcttacacc
accaggggtggcaagattcctatccggtggactgcgccagaagcaattgcctatcgtaaa
ttcacatcagcaagtgatgtatggagctatggaatcgttatgtgggaagtgatgtcgtac
ggggagaggccctattgggatatgtccaatcaagatgtgattaaagccattgaggaaggc
tatcggttaccccctccaatggactgccccattgcgctccaccagctgatgctagactgc
tggcagaaggagaggagcgacaggcctaaatttgggcagattgtcaacatgttggacaaa
ctcatccgcaaccccaacagcttgaagaggacagggacggagagctccagacctaacact
gccttgttggatccaagctcccctgaattctctgctgtggtatcagtgggcgattggctc
caggccattaaaatggaccggtataaggataacttcacagctgctggttataccacacta
gaggctgtggtgcacgtgaaccaggaggacctggcaagaattggtatcacagccatcacg
caccagaataagattttgagcagtgtccaggcaatgcgaacccaaatgcagcagatgcac
ggcagaatggttcccgtctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (42)   
   RefSeq(nuc) (4)   
   GenBank (19)   
   EMBL (19)   
3D Structure (16)   
   PDB (16)   
Protein domain (17)   
   Pfam (17)   
All databases (101)   

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