KEGG   Homo sapiens (human): 2047
Entry
2047              CDS       T01001                                 
Symbol
EPHB1, ELK, EPHT2, Hek6, NET
Name
(RefSeq) EPH receptor B1
  KO
K05110  Eph receptor B1 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Drug target
Sitravatinib (DG03045): D11140 D11541
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    2047 (EPHB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2047 (EPHB1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2047 (EPHB1)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  EPH family [OT]
   2047 (EPHB1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Ephrin_lbd Pkinase fn3 EphA2_TM SAM_1 SAM_2 Pur_ac_phosph_N ABC1 Ephrin_rec_like VSP CRLF2-like_D2 cEGF DAP10 Haspin_kinase EGF_2
Other DBs
NCBI-GeneID: 2047
NCBI-ProteinID: NP_004432
OMIM: 600600
HGNC: 3392
Ensembl: ENSG00000154928
UniProt: P54762
Structure
Position
3:134795260..135260467
AA seq 984 aa
MALDYLLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQV
CNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSV
IATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDY
GACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYC
NGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPI
CTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIIC
KKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPP
QHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFN
SSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLP
LIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTY
EDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK
QRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ
LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTS
SLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD
YRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQ
PLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAG
HQKKILNSIHSMRVQISQSPTAMA
NT seq 2955 nt   +upstreamnt  +downstreamnt
atggccctggattatctactactgctcctcctggcatccgcagtggctgcgatggaagaa
acgttaatggacaccagaacggctactgcagagctgggctggacggccaatcctgcgtcc
gggtgggaagaagtcagtggctacgatgaaaacctgaacaccatccgcacctaccaggtg
tgcaatgtcttcgagcccaaccagaacaattggctgctcaccaccttcatcaaccggcgg
ggggcccatcgcatctacacagagatgcgcttcactgtgagagactgcagcagcctccct
aatgtcccaggatcctgcaaggagaccttcaacttgtattactatgagactgactctgtc
attgccaccaagaagtcagccttctggtctgaggccccctacctcaaagtagacaccatt
gctgcagatgagagcttctcccaggtggactttgggggaaggctgatgaaggtaaacaca
gaagtcaggagctttgggcctcttactcggaatggtttttacctcgcttttcaggattat
ggagcctgtatgtctcttctttctgtccgtgtcttcttcaaaaagtgtcccagcattgtg
caaaattttgcagtgtttccagagactatgacaggggcagagagcacatctctggtgatt
gctcggggcacatgcatccccaacgcagaggaagtggacgtgcccatcaaactctactgc
aacggggatggggaatggatggtgcctattgggcgatgcacctgcaagcctggctatgag
cctgagaacagcgtggcatgcaaggcttgccctgcagggacattcaaggccagccaggaa
gctgaaggctgctcccactgcccctccaacagccgctcccctgcagaggcgtctcccatc
tgcacctgtcggaccggttattaccgagcggactttgaccctccagaagtggcatgcact
agcgtcccatcaggtccccgcaatgttatctccatcgtcaatgagacgtccatcattctg
gagtggcaccctccaagggagacaggtgggcgggatgatgtgacctacaacatcatctgc
aaaaagtgccgggcagaccgccggagctgctcccgctgtgacgacaatgtggagtttgtg
cccaggcagctgggcctgacggagtgccgcgtctccatcagcagcctgtgggcccacacc
ccctacacctttgacatccaggccatcaatggagtctccagcaagagtcccttcccccca
cagcacgtctctgtcaacatcaccacaaaccaagccgccccctccaccgttcccatcatg
caccaagtcagtgccactatgaggagcatcaccttgtcatggccacagccggagcagccc
aatggcatcatcctggactatgagatccggtactatgagaaggaacacaatgagttcaac
tcctccatggccaggagtcagaccaacacagcaaggattgatgggctgcggcctggcatg
gtatatgtggtacaggtgcgtgcccgcactgttgctggctacggcaagttcagtggcaag
atgtgcttccagactctgactgacgatgattacaagtcagagctgagggagcagctgccc
ctgattgctggctcggcagcggccggggtcgtgttcgttgtgtccttggtggccatctct
atcgtctgtagcaggaaacgggcttatagcaaagaggctgtgtacagcgataagctccag
cattacagcacaggccgaggctccccagggatgaagatctacattgaccccttcacttac
gaggatcccaacgaagctgtccgggagtttgccaaggagattgatgtatcttttgtgaaa
attgaagaggtcatcggagcaggggagtttggagaagtgtacaaggggcgtttgaaactg
ccaggcaagagggaaatctacgtggccatcaagaccctgaaggcagggtactcggagaag
cagcgtcgggactttctgagtgaggcgagcatcatgggccagttcgaccatcctaacatc
attcgcctggagggtgtggtcaccaagagtcggcctgtcatgatcatcacagagttcatg
gagaatggtgcattggattctttcctcaggcaaaatgacgggcagttcaccgtgatccag
cttgtgggtatgctcaggggcatcgctgctggcatgaagtacctggctgagatgaattat
gtgcatcgggacctggctgctaggaacattctggtcaacagtaacctggtgtgcaaggtg
tccgactttggcctctcccgctacctccaggatgacacctcagatcccacctacaccagc
tccttgggagggaagatccctgtgagatggacagctccagaggccatcgcctaccgcaag
ttcacttcagccagcgacgtttggagctatgggatcgtcatgtgggaagtcatgtcattt
ggagagagaccctattgggatatgtccaaccaagatgtcatcaatgccatcgagcaggac
taccggctgcccccacccatggactgtccagctgctctacaccagctcatgctggactgt
tggcagaaggaccggaacagccggccccggtttgcggagattgtcaacaccctagataag
atgatccggaacccggcaagtctcaagactgtggcaaccatcaccgccgtgccttcccag
cccctgctcgaccgctccatcccagacttcacggcctttaccaccgtggatgactggctc
agcgccatcaaaatggtccagtacagggacagcttcctcactgctggcttcacctccctc
cagctggtcacccagatgacatcagaagacctcctgagaataggcatcaccttggcaggc
catcagaagaagatcctgaacagcattcattctatgagggtccagataagtcagtcacca
acggcaatggcatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (8)   
   PDB (8)   
Protein domain (16)   
   Pfam (16)   
All databases (71)   

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