KEGG   Homo sapiens (human): 2159
Entry
2159              CDS       T01001                                 
Symbol
F10, FX, FXA
Name
(RefSeq) coagulation factor X
  KO
K01314  coagulation factor X [EC:3.4.21.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
  Element
N01510  Common pathway of coagulation cascade, F10 activation
Disease
H02257  Factor X deficiency
Drug target
Andexanet alfa: D11029<JP/US>
Apixaban: D03213<JP/US>
Betrixaban: D08873
Darexaban maleate: D09817
Denecimig: D12797
Edoxaban (DG01398): D09546<JP/US> D09710 D11568
Emicizumab: D10821<JP/US>
Eribaxaban: D08913
Factor VIII inhibitor bypassing activity: D12421<JP>
Fidexaban: D04183
Fondaparinux: D01844<JP/US>
Idraparinux sodium: D10471
Letaxaban: D09923
Razaxaban hydrochloride: D04029
Rivaroxaban: D07086<JP/US>
Tifacogin: D06142
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2159 (F10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    2159 (F10)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2159 (F10)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.6  coagulation factor Xa
     2159 (F10)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   2159 (F10)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   2159 (F10)
SSDB
Motif
Pfam: Trypsin Gla FXa_inhibition cEGF EGF hEGF DUF1986 EGF_3 Trypsin_2
Other DBs
NCBI-GeneID: 2159
NCBI-ProteinID: NP_000495
OMIM: 613872
HGNC: 3528
Ensembl: ENSG00000126218
CPD: C01065
UniProt: P00742 Q5JVE7
Structure
Position
13:113122799..113149529
AA seq 488 aa
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
NT seq 1467 nt   +upstreamnt  +downstreamnt
atggggcgcccactgcacctcgtcctgctcagtgcctccctggctggcctcctgctgctc
ggggaaagtctgttcatccgcagggagcaggccaacaacatcctggcgagggtcacgagg
gccaattcctttcttgaagagatgaagaaaggacacctcgaaagagagtgcatggaagag
acctgctcatacgaagaggcccgcgaggtctttgaggacagcgacaagacgaatgaattc
tggaataaatacaaagatggcgaccagtgtgagaccagtccttgccagaaccagggcaaa
tgtaaagacggcctcggggaatacacctgcacctgtttagaaggattcgaaggcaaaaac
tgtgaattattcacacggaagctctgcagcctggacaacggggactgtgaccagttctgc
cacgaggaacagaactctgtggtgtgctcctgcgcccgcgggtacaccctggctgacaac
ggcaaggcctgcattcccacagggccctacccctgtgggaaacagaccctggaacgcagg
aagaggtcagtggcccaggccaccagcagcagcggggaggcccctgacagcatcacatgg
aagccatatgatgcagccgacctggaccccaccgagaaccccttcgacctgcttgacttc
aaccagacgcagcctgagaggggcgacaacaacctcaccaggatcgtgggaggccaggaa
tgcaaggacggggagtgtccctggcaggccctgctcatcaatgaggaaaacgagggtttc
tgtggtggaaccattctgagcgagttctacatcctaacggcagcccactgtctctaccaa
gccaagagattcaaggtgagggtaggggaccggaacacggagcaggaggagggcggtgag
gcggtgcacgaggtggaggtggtcatcaagcacaaccggttcacaaaggagacctatgac
ttcgacatcgccgtgctccggctcaagacccccatcaccttccgcatgaacgtggcgcct
gcctgcctccccgagcgtgactgggccgagtccacgctgatgacgcagaagacggggatt
gtgagcggcttcgggcgcacccacgagaagggccggcagtccaccaggctcaagatgctg
gaggtgccctacgtggaccgcaacagctgcaagctgtccagcagcttcatcatcacccag
aacatgttctgtgccggctacgacaccaagcaggaggatgcctgccagggggacagcggg
ggcccgcacgtcacccgcttcaaggacacctacttcgtgacaggcatcgtcagctgggga
gagggctgtgcccgtaaggggaagtacgggatctacaccaaggtcaccgccttcctcaag
tggatcgacaggtccatgaaaaccaggggcttgcccaaggccaagagccatgccccggag
gtcataacgtcctctccattaaagtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (18)   
   KEGG DRUG (18)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
3D Structure (160)   
   PDB (160)   
Protein domain (9)   
   Pfam (9)   
All databases (251)   

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