KEGG   Homo sapiens (human): 2193
Entry
2193              CDS       T01001                                 
Symbol
FARSA, CML33, FARSL, FARSLA, FRSA, PheHA, RILDBC2
Name
(RefSeq) phenylalanyl-tRNA synthetase subunit alpha
  KO
K01889  phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02466  Rajab interstitial lung disease with brain calcification
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    2193 (FARSA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    2193 (FARSA)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    2193 (FARSA)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.20  phenylalanine---tRNA ligase
     2193 (FARSA)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (U)
   2193 (FARSA)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    2193 (FARSA)
 Prokaryotic type
    2193 (FARSA)
SSDB
Motif
Pfam: tRNA-synt_2d PheRS_DBD1 PheRS_DBD3 PheRS_DBD2 MarR_2 tRNA_synthFbeta tRNA-synt_2 HTH_11 DUF1204
Other DBs
NCBI-GeneID: 2193
NCBI-ProteinID: NP_004452
OMIM: 602918
HGNC: 3592
Ensembl: ENSG00000179115
UniProt: Q9Y285 Q6IBR2
Structure
Position
19:complement(12922479..12933711)
AA seq 508 aa
MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKH
WELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAA
DGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSA
FSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLE
MGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTH
SQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNE
TLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVF
SYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGH
KVNLQMVYDSPLCRLDAEPRPPPTQEAA
NT seq 1527 nt   +upstreamnt  +downstreamnt
atggcggatggtcaggtggcggaactgctgctccggcggctggaggcgtctgatggcggc
ctggacagcgccgagttggcggctgagctgggcatggagcaccaggcggtggtgggcgcc
gtgaagagccttcaggcgctgggcgaggtcatcgaggctgaacttcggtccaccaagcac
tgggagcttactgcggagggcgaggagattgcccgggagggcagccatgaggcccgtgtg
tttcgaagcattcccccagagggcctggcccagagcgagcttatgcgactgcccagtggc
aaagtgggcttcagcaaggccatgtccaacaagtggattcgggtggacaagagtgcggct
gacgggccccgggtgttccgagtggtggacagcatggaggatgaggtgcagcggcggctc
cagctggtccgggggggacaggctgagaagctgggggagaaggagaggagcgagctgagg
aagaggaagctgttggctgaagtgactctgaagacctactgggtgagcaaaggcagtgcc
tttagtaccagcatctccaagcaagagacagagctgagcccagagatgatctccagtggc
tcttggcgggaccggcccttcaagccctacaacttcttggcccacggtgtcctccccgac
agcggccaccttcacccgctgctcaaggtccgctcccagttccgacagatcttcctggag
atggggttcaccgagatgccgactgataacttcattgagagctccttctggaactttgac
gccctcttccagccccagcagcacccagcccgtgaccagcacgacaccttcttccttcga
gatccagcggaggccctgcagctcccaatggactatgtccagcgggtcaagcggacccac
tctcagggcggctacggctcacaggggtacaagtataactggaagctggacgaggcccgg
aaaaacctactgcgaacccacaccacatcagccagcgcccgtgcgctctaccgccttgcc
cagaagaagcccttcactccggtcaagtacttctccatcgaccgcgtattccggaatgag
accctggacgccacgcacctggctgagttccaccagatcgagggcgtggtggcggatcat
ggtctcaccttgggccacctcatgggcgttctgcgggagttcttcaccaagctgggtatc
acgcaactccgcttcaagccagcctacaacccatacacagagcccagcatggaggtgttc
agctaccaccaaggcctgaagaagtgggtggaggtcggaaactcgggggtcttccgtcca
gagatgctgctgcccatggggcttcccgagaacgtgtcggtcattgcctggggcctctcc
ctggagcgcccaacgatgatcaaatatggcatcaacaatatccgggagctggtgggccac
aaggtgaacctgcagatggtgtatgacagtcccctgtgccgcctggatgccgagccgagg
ccccctcccacacaggaggctgcgtga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (9)   
   Pfam (9)   
All databases (73)   

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