KEGG   Homo sapiens (human): 2235
Entry
2235              CDS       T01001                                 
Symbol
FECH, EPP, EPP1, FCE
Name
(RefSeq) ferrochelatase
  KO
K01772  protoporphyrin/coproporphyrin ferrochelatase [EC:4.98.1.1 4.99.1.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00860  Porphyrin metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00868  Heme biosynthesis, animals and fungi, glycine => heme
Network
nt06011  Heme biosynthesis
  Element
N00601  Heme biosynthesis
Disease
H00201  Erythropoietic porphyria
H01763  Porphyria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    2235 (FECH)
Enzymes [BR:hsa01000]
 4. Lyases
  4.98  ATP-independent chelatases
   4.98.1  Forming coordination complexes
    4.98.1.1  protoporphyrin ferrochelatase
     2235 (FECH)
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.9  coproporphyrin ferrochelatase
     2235 (FECH)
SSDB
Motif
Pfam: Ferrochelatase
Other DBs
NCBI-GeneID: 2235
NCBI-ProteinID: NP_000131
OMIM: 612386
HGNC: 3647
Ensembl: ENSG00000066926
UniProt: P22830 Q7KZA3
Structure
Position
18:complement(57544377..57586702)
AA seq 423 aa
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
NT seq 1272 nt   +upstreamnt  +downstreamnt
atgcgttcactcggcgcaaacatggctgcggccctgcgcgccgcgggcgtcctgctccgc
gatccgctggcatccagcagctggagggtctgtcagccatggaggtggaagtcaggtgca
gctgcagcggccgtcaccacagaaacagcccagcatgcccagggtgcaaaacctcaagtt
caaccgcagaagaggaagccgaaaactggaatattaatgctaaacatgggaggccctgaa
actcttggagatgttcacgacttccttctgagactcttcttggaccgagacctcatgaca
cttcctattcagaataagctggcaccattcatcgccaaacgccgaacccccaagattcaa
gagcagtaccgcaggattggaggcggatcccccatcaagatatggacttccaagcaggga
gagggcatggtgaagctgctggatgaattgtcccccaacacagcccctcacaaatactat
attggatttcggtacgtccatcctttaacagaagaagcaattgaagagatggagagagat
ggcctagaaagggctattgctttcacacagtatccacagtacagctgctccaccacaggc
agcagcttaaatgccatttacagatactataatcaagtgggacggaagcccacgatgaag
tggagcactattgacaggtggcccacacatcacctcctcatccagtgctttgcagatcat
attctaaaggaactggaccattttccacttgagaagagaagcgaggtggtcattctgttt
tctgctcactcactgcccatgtctgtggtcaacagaggcgacccatatcctcaggaggta
agcgccactgtccaaaaagtcatggaaaggctggagtactgcaacccctaccgactggtg
tggcaatccaaggttggtccaatgccctggttgggtcctcaaacagacgaatctatcaaa
gggctttgtgagagggggaggaagaatatcctcttggttccgatagcatttaccagtgac
catattgaaacgctgtatgagctggacatcgagtactctcaagttttagccaaggagtgt
ggagttgaaaacatcagaagagctgagtctcttaatggaaatccattgttctctaaggcc
ctggccgacttggtgcattcacacatccagtcaaacgagctgtgttccaagcagctgacc
ctgagctgtccgctctgtgtcaatcctgtctgcagggagactaaatccttcttcaccagc
cagcagctgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (3)   
   KEGG MODULE (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (37)   
   RefSeq(nuc) (7)   
   GenBank (15)   
   EMBL (15)   
3D Structure (25)   
   PDB (25)   
Protein domain (1)   
   Pfam (1)   
All databases (113)   

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