KEGG   Homo sapiens (human): 2237
Entry
2237              CDS       T01001                                 
Symbol
FEN1, FEN-1, MF1, RAD2
Name
(RefSeq) flap structure-specific endonuclease 1
  KO
K04799  flap endonuclease-1 [EC:3.1.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03450  Non-homologous end-joining
Network
nt06504  Base excision repair
nt06509  DNA replication
  Element
N01436  Long patch BER
N01472  Okazaki fragment maturation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    2237 (FEN1)
   03410 Base excision repair
    2237 (FEN1)
   03450 Non-homologous end-joining
    2237 (FEN1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    2237 (FEN1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    2237 (FEN1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2237 (FEN1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   Other elongation factors
    2237 (FEN1)
 Prokaryotic type
   Elongation factors (archaeal)
    Other elongation factors
     2237 (FEN1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     2237 (FEN1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2237 (FEN1)
SSDB
Motif
Pfam: XPG_N XPG_I 5_3_exonuc HHH_5 Maelstrom
Other DBs
NCBI-GeneID: 2237
NCBI-ProteinID: NP_004102
OMIM: 600393
HGNC: 3650
Ensembl: ENSG00000168496
UniProt: P39748 Q6FHX6
Structure
Position
11:61792911..61797238
AA seq 380 aa
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
NT seq 1143 nt   +upstreamnt  +downstreamnt
atgggaattcaaggcctggccaaactaattgctgatgtggcccccagtgccatccgggag
aatgacatcaagagctactttggccgtaaggtggccattgatgcctctatgagcatttat
cagttcctgattgctgttcgccagggtggggatgtgctgcagaatgaggagggtgagacc
accagccacctgatgggcatgttctaccgcaccattcgcatgatggagaacggcatcaag
cccgtgtatgtctttgatggcaagccgccacagctcaagtcaggcgagctggccaaacgc
agtgagcggcgggctgaggcagagaagcagctgcagcaggctcaggctgctggggccgag
caggaggtggaaaaattcactaagcggctggtgaaggtcactaagcagcacaatgatgag
tgcaaacatctgctgagcctcatgggcatcccttatcttgatgcacccagtgaggcagag
gccagctgtgctgccctggtgaaggctggcaaagtctatgctgcggctaccgaggacatg
gactgcctcaccttcggcagccctgtgctaatgcgacacctgactgccagtgaagccaaa
aagctgccaatccaggaattccacctgagccggattctgcaggagctgggcctgaaccag
gaacagtttgtggatctgtgcatcctgctaggcagtgactactgtgagagtatccggggt
attgggcccaagcgggctgtggacctcatccagaagcacaagagcatcgaggagatcgtg
cggcgacttgaccccaacaagtaccctgtgccagaaaattggctccacaaggaggctcac
cagctcttcttggaacctgaggtgctggacccagagtctgtggagctgaagtggagcgag
ccaaatgaagaagagctgatcaagttcatgtgtggtgaaaagcagttctctgaggagcga
atccgcagtggggtcaagaggctgagtaagagccgccaaggcagcacccagggccgcctg
gatgatttcttcaaggtgaccggctcactctcttcagctaagcgcaaggagccagaaccc
aagggatccactaagaagaaggcaaagactggggcagcagggaagtttaaaaggggaaaa
taa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (4)   
   KEGG NETWORK (4)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (17)   
   PDB (17)   
Protein domain (5)   
   Pfam (5)   
All databases (79)   

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