KEGG   Homo sapiens (human): 2243
Entry
2243              CDS       T01001                                 
Symbol
FGA, Fib2
Name
(RefSeq) fibrinogen alpha chain
  KO
K03903  fibrinogen alpha chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06514  Coagulation cascade
  Element
N01502  Lectin pathway of coagulation cascade, fibrinogen to fibrin
N01513  Common pathway of coagulation cascade, fibrinogen to fibrin
Disease
H00222  Afibrinogenemia
H00223  Inherited thrombophilia
H00845  Familial amyloidosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2243 (FGA)
   04611 Platelet activation
    2243 (FGA)
   04613 Neutrophil extracellular trap formation
    2243 (FGA)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    2243 (FGA)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2243 (FGA)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    2243 (FGA)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   2243 (FGA)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   2243 (FGA)
 Hyaluronan
  Extracellular matrix or blood plasma proteins
   2243 (FGA)
SSDB
Motif
Pfam: Fibrinogen_C Fib_alpha Fibrinogen_aC DUF6387
Other DBs
NCBI-GeneID: 2243
NCBI-ProteinID: NP_000499
OMIM: 134820
HGNC: 3661
Ensembl: ENSG00000171560
CPD: C00290 C00952
UniProt: P02671
Structure
Position
4:complement(154583126..154590742)
AA seq 866 aa
MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDW
NYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSA
NNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSC
RGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQ
LQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSS
GPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTW
NPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNV
SPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTK
EVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEF
VSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKS
YKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFS
VYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQR
GSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSH
NNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENG
VVWVSFRGADYSLRAVRMKIRPLVTQ
NT seq 2601 nt   +upstreamnt  +downstreamnt
atgttttccatgaggatcgtctgcctggtcctaagtgtggtgggcacagcatggactgca
gatagtggtgaaggtgactttctagctgaaggaggaggcgtgcgtggcccaagggttgtg
gaaagacatcaatctgcctgcaaagattcagactggcccttctgctctgatgaagactgg
aactacaaatgcccttctggctgcaggatgaaagggttgattgatgaagtcaatcaagat
tttacaaacagaataaataagctcaaaaattcactatttgaatatcagaagaacaataag
gattctcattcgttgaccactaatataatggaaattttgagaggcgatttttcctcagcc
aataaccgtgataatacctacaaccgagtgtcagaggatctgagaagcagaattgaagtc
ctgaagcgcaaagtcatagaaaaagtacagcatatccagcttctgcagaaaaatgttaga
gctcagttggttgatatgaaacgactggaggtggacattgatattaagatccgatcttgt
cgagggtcatgcagtagggctttagctcgtgaagtagatctgaaggactatgaagatcag
cagaagcaacttgaacaggtcattgccaaagacttacttccctctagagataggcaacac
ttaccactgataaaaatgaaaccagttccagacttggttcccggaaattttaagagccag
cttcagaaggtacccccagagtggaaggcattaacagacatgccgcagatgagaatggag
ttagagagacctggtggaaatgagattactcgaggaggctccacctcttatggaaccgga
tcagagacggaaagccccaggaaccctagcagtgctggaagctggaactctgggagctct
ggacctggaagtactggaaaccgaaaccctgggagctctgggactggagggactgcaacc
tggaaacctgggagctctggacctggaagtactggaagctggaactctgggagctctgga
actggaagtactggaaaccaaaaccctgggagccctagacctggtagtaccggaacctgg
aatcctggcagctctgaacgcggaagtgctgggcactggacctctgagagctctgtatct
ggtagtactggacaatggcactctgaatctggaagttttaggccagatagcccaggctct
gggaacgcgaggcctaacaacccagactggggcacatttgaagaggtgtcaggaaatgta
agtccagggacaaggagagagtaccacacagaaaaactggtcacttctaaaggagataaa
gagctcaggactggtaaagagaaggtcacctctggtagcacaaccaccacgcgtcgttca
tgctctaaaaccgttactaagactgttattggtcctgatggtcacaaagaagttaccaaa
gaagtggtgacctccgaagatggttctgactgtcccgaggcaatggatttaggcacattg
tctggcataggtactctggatgggttccgccataggcaccctgatgaagctgccttcttc
gacactgcctcaactggaaaaacattcccaggtttcttctcacctatgttaggagagttt
gtcagtgagactgagtctaggggctcagaatctggcatcttcacaaatacaaaggaatcc
agttctcatcaccctgggatagctgaattcccttcccgtggtaaatcttcaagttacagc
aaacaatttactagtagcacgagttacaacagaggagactccacatttgaaagcaagagc
tataaaatggcagatgaggccggaagtgaagccgatcatgaaggaacacatagcaccaag
agaggccatgctaaatctcgccctgtcagagactgtgatgatgtcctccaaacacatcct
tcaggtacccaaagtggcattttcaatatcaagctaccgggatccagtaagattttttct
gtttattgcgatcaagagaccagtttgggaggatggcttttgatccagcaaagaatggat
ggatcactgaattttaaccggacctggcaagactacaagagaggtttcggcagcctgaat
gacgagggggaaggagaattctggctaggcaatgactacctccacttactaacccaaagg
ggctctgttcttagggttgaattagaggactgggctgggaatgaagcttatgcagaatat
cacttccgggtaggctctgaggctgaaggctatgccctccaagtctcctcctatgaaggc
actgcgggtgatgctctgattgagggttccgtagaggaaggggcagagtacacctctcac
aacaacatgcagttcagcacctttgacagggatgcagaccagtgggaagagaactgtgca
gaagtctatgggggaggctggtggtataataactgccaagcagccaatctcaatggaatc
tactaccctgggggctcctatgacccaaggaataacagtccttatgagattgagaatgga
gtggtctgggtttcctttagaggggcagattattccctcagggctgttcgcatgaaaatt
aggccccttgtgacccaatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (4)   
   KEGG NETWORK (4)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG ORTHOLOGY (1)   
   RefGene (35)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (55)   
   RefSeq(nuc) (3)   
   GenBank (26)   
   EMBL (26)   
3D Structure (39)   
   PDB (39)   
Protein domain (4)   
   Pfam (4)   
All databases (163)   

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