KEGG   Homo sapiens (human): 22803
Entry
22803             CDS       T01001                                 
Symbol
XRN2
Name
(RefSeq) 5'-3' exoribonuclease 2
  KO
K12619  5'-3' exoribonuclease 2 [EC:3.1.13.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03008  Ribosome biogenesis in eukaryotes
hsa03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03008 Ribosome biogenesis in eukaryotes
    22803 (XRN2)
  09123 Folding, sorting and degradation
   03018 RNA degradation
    22803 (XRN2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    22803 (XRN2)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    22803 (XRN2)
   03009 Ribosome biogenesis [BR:hsa03009]
    22803 (XRN2)
   03016 Transfer RNA biogenesis [BR:hsa03016]
    22803 (XRN2)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     22803 (XRN2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA degradation factors
   5'-3' decay
    5' exonucleases
     22803 (XRN2)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic type
  Pre-60S particles
   RNases
    22803 (XRN2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  tRNA degradation factors
   Rapid tRNA decay (RTD) pathway factors
    22803 (XRN2)
SSDB
Motif
Pfam: XRN_M XRN_N
Other DBs
NCBI-GeneID: 22803
NCBI-ProteinID: NP_036387
OMIM: 608851
HGNC: 12836
Ensembl: ENSG00000088930
UniProt: Q9H0D6
Position
20:21303331..21389825
AA seq 950 aa
MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIH
PCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFR
ASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIAD
RLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLG
LATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGE
FIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAI
DRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKE
KRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSF
TSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQ
SYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMG
VFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRA
ALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQG
KFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAV
LKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVT
YQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQ
NAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN
NT seq 2853 nt   +upstreamnt  +downstreamnt
atgggagtcccggcgttcttccgctggctcagccgcaagtacccgtccatcatagtcaac
tgcgtggaagagaagccaaaagaatgcaatggtgtaaagattccagttgatgccagtaaa
cctaatccaaatgatgtggagtttgataatctgtatttggatatgaatggaatcatccat
ccctgtactcatcctgaagacaaaccagcaccaaaaaatgaagatgaaatgatggttgca
atttttgagtacattgacagacttttcagtattgtaagaccaagaagacttctctacatg
gcaatagatggagtggcaccacgtgctaaaatgaaccagcagcgttcaaggaggttcagg
gcatcaaaagaaggaatggaagcagcagtcgagaagcagcgagtcagggaagaaatattg
gcaaaaggtggctttcttcctccagaagaaataaaagaaagatttgacagcaactgtatt
acaccaggaactgaattcatggacaatcttgctaaatgccttcgctattacatagctgat
cgtttaaataatgaccctgggtggaaaaatttgacagttattttatctgatgctagtgct
cctggtgaaggagaacataaaatcatggattacattagaaggcaaagagcccagcctaac
catgacccaaatactcatcattgtttatgtggagcagatgctgatctcattatgcttggc
cttgccacacatgaaccgaactttaccattattagagaagaattcaaaccaaacaagccc
aaaccatgtggtctttgtaatcagtttggacatgaggtcaaagattgtgaaggtttgcca
agagaaaagaagggaaagcatgatgaacttgccgatagtcttccttgtgcagaaggagag
tttatcttccttcggcttaatgttcttcgtgagtatttggaaagagaactcacaatggcc
agcctaccattcacatttgatgttgagaggagcattgatgactgggttttcatgtgcttc
tttgtgggaaatgacttcctccctcatttgccatcgttagagattagggaaaatgcaatt
gaccgtttggttaacatatacaaaaatgtggtacacaaaactgggggttaccttacagaa
agtggttatgtcaatctgcaaagagtacagatgatcatgttagcagttggtgaagttgag
gatagcatttttaaaaagagaaaggatgatgaggacagttttagaagacgacagaaagaa
aaaagaaagagaatgaagagagatcaaccagctttcactcctagtggaatattaactcct
catgccttgggttcaagaaattcaccaggttctcaagtagccagtaatccgagacaagca
gcctatgaaatgaggatgcagaataactctagtccttcgatatctcctaatacgagtttc
acatctgatggctccccgtctccattaggaggaattaagcgaaaagcagaagacagtgac
agtgaacctgagccagaggataatgtcaggttatgggaagctggctggaagcagcggtac
tacaagaacaaatttgatgtggatgcagctgatgagaaattccgtcggaaagttgtgcag
tcgtacgttgaaggactttgctgggttcttagatattattaccagggctgtgcttcctgg
aagtggtattatccatttcattatgcaccatttgcttcagactttgaaggcattgcagac
atgccatctgattttgagaagggtacgaaaccgtttaaaccactagaacaacttatgggg
gtatttccagctgcaagtggtaattttctacctccatcatggcggaagctcatgagtgat
cctgattctagtataattgacttctatcctgaagattttgctattgatttgaatgggaag
aaatatgcatggcaaggtgttgctctcttgccattcgtggatgagcgaaggctacgagct
gccctagaagaggtatacccagacctcactccagaagagaccagaagaaacagccttgga
ggtgatgtcttatttgtggggaaacatcacccactccatgacttcattttagagctgtac
cagacaggttccacagagccagtggaggtaccccctgaactatgtcatgggattcaagga
aagttttctttggatgaagaagccattcttccagatcaaatagtatgttctcctgttcct
atgttaagggatctgacacagaacactgtagtcagtattaattttaaagacccacagttt
gctgaagattacatttttaaagctgtaatgcttccaggagcaagaaagccagcagcagta
ctgaaacctagtgactgggaaaaatccagcaatggacggcagtggaagcctcagcttggc
tttaaccgtgaccggaggcctgtgcacctggatcaggcagccttcaggactttgggccat
gtgatgccaagaggctcaggaactggcatttacagcaatgctgcaccaccacctgtgact
taccagggaaacttatacaggccgcttttgagaggacaagcccagattccaaaacttatg
tcaaatatgaggccccaggattcctggcgaggtcctcctccccttttccagcagcaaagg
tttgacagaggcgttggggctgaacctctgctcccatggaaccggatgctgcaaacccag
aatgcagccttccagccaaaccagtaccagatgctagctgggcctggtgggtatccaccc
agacgagatgatcgtggagggagacagggatatcccagagaaggaaggaaataccctttg
ccaccaccctcaggaagatacaattggaattaa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (44)   
   RefSeq(nuc) (6)   
   GenBank (19)   
   EMBL (19)   
Protein domain (2)   
   Pfam (2)   
All databases (90)   

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