KEGG   Homo sapiens (human): 22866
Entry
22866             CDS       T01001                                 
Symbol
CNKSR2, CNK2, KSR2, MAGUIN, MRXSHG
Name
(RefSeq) connector enhancer of kinase suppressor of Ras 2
  KO
K17536  connector enhancer of kinase suppressor of Ras 2
Organism
hsa  Homo sapiens (human)
Disease
H00658  X-linked syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    22866 (CNKSR2)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 PDZ domain-containing proteins
  Other PDZ domain-containing proteins
   22866 (CNKSR2)
SSDB
Motif
Pfam: CNK2_3_dom CRIC_ras_sig PH SAM_1 SAM_2 PDZ PDZ_6 PDZ_2 SAM_PNT PH_13
Other DBs
NCBI-GeneID: 22866
NCBI-ProteinID: NP_055742
OMIM: 300724
HGNC: 19701
Ensembl: ENSG00000149970
UniProt: Q8WXI2
Structure
Position
X:21374418..21654689
AA seq 1034 aa
MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRI
GHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKL
PNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYET
ENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHV
ITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM
LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEP
YIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKG
RSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQE
EYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQ
SSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKD
ASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRW
LNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCAS
PYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSG
LHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGG
KPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSES
REEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKS
TLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVIT
SSLAHTHSYIETHV
NT seq 3105 nt   +upstreamnt  +downstreamnt
atggctctgataatggaaccggtgagcaaatggtctccgagtcaagtagtggactggatg
aaaggtcttgatgactgtttgcagcagtatattaagaactttgagagggagaagatcagt
ggggaccagctgctgcgcattacacatcaggagctagaagatctgggggtcagccgcatt
ggccatcaggaactgatcttggaagcagttgaccttctgtgtgcattgaattatggcttg
gaaacagaaaatctaaaaaccctttctcacaagttgaatgcatctgccaaaaatctgcag
aattttataacaggaaggagaaggagtggccattatgatgggaggaccagccgaaaattg
ccaaacgactttctgacctcagttgtggatctgattggagcagccaagagtctgcttgcc
tggttggacaggtcaccatttgctgctgtgacagactattcagttacaagaaataatgtc
atacaactctgcctggagttaacaacaattgtgcaacaggattgtactgtatatgaaaca
gagaataaaattcttcacgtgtgtaaaactctttctggagtctgtgaccacatcatatcc
ctgtcgtcagatcctctggtttcacagtctgctcacctggaagtgattcaactggcaaac
attaaaccaagcgaagggctgggtatgtatattaaatctacatatgatggcctccatgta
attactggaaccacagaaaattcacctgcagatcggtgcaagaaaatccatgctggcgat
gaagtgattcaagttaatcatcagactgtggtggggtggcagttgaaaaatttggtgaat
gcactacgagaggacccgagtggtgttatcttaactttgaaaaagcgacctcagagcatg
cttacctcagcaccagctttactgaaaaatatgagatggaagccccttgctctgcagcct
cttatacctagaagtcccacaagcagcgttgccacgccttccagcaccatcagtacaccc
accaaaagagacagttctgccctccaggatctctacattccccctcctcctgcagaacca
tatattcccagggatgaaaaaggaaaccttccttgtgaagacctcagaggacatatggtg
ggcaagccagtgcataagggatctgaatcaccaaattcatttctggatcaggaatatcga
aagagatttaatattgtcgaagaagatactgtcttatattgctatgaatatgaaaaagga
agatcaagtagtcaaggaagacgagaaagcaccccaacttatggcaagctacgacctata
tctatgccagtggaatataattgggtgggggactatgaagatccaaataagatgaagaga
gatagtagaagagaaaactctctacttcggtatatgagcaatgaaaagattgctcaagaa
gaatacatgtttcagagaaacagcaaaaaggacacagggaagaagtcaaaaaagaagggt
gataagagtaatagcccaactcactattcattgctacctagtttacaaatggatgcactg
agacaagacatcatgggcactcctgtgccagagaccacactataccatacatttcagcag
tcctcactgcagcacaaatcaaagaagaaaaacaaaggtcctatagcaggcaagagcaaa
agacgaatttcttgcaaagatcttggccgtggtgactgtgagggctggctttggaaaaag
aaagatgcgaagagttacttttcacagaaatggaaaaaatattggtttgtcctaaaggat
gcatccctttattggtatattaatgaggaggatgaaaaagcagaaggattcattagcctg
cctgaatttaaaattgatagagccagtgaatgccgcaaaaaatatgcattcaaagcctgt
catcctaaaatcaaaagcttttattttgctgctgaacatcttgatgatatgaacaggtgg
cttaacagaattaatatgctgactgcaggatatgcagaaagagagaggattaagcaggaa
caagattactggagtgagagtgacaaggaagaagcagatactccatcaacaccaaaacaa
gatagccctccacccccatatgatacatacccacgacctccctcgatgagttgcgccagt
ccttatgtggaagcaaaacatagccgactttcctccacggagacttctcagtctcagtct
tctcatgaggagtttcgccaggaagtaactgggagcagtgcagtgtctcccattcgcaag
acagccagtcagcgccgctcctggcaggatttaattgagacgccactgacaagttcaggc
ttacactatcttcagactctgcccctggaggattctgtcttctctgactccgcggccatc
tccccagagcacaggcggcagtctaccctgccaactcagaaatgccacctgcaggatcac
tatgggccataccccttagctgagagtgagaggatgcaagtgctaaatggaaatgggggc
aagcctcgaagttttactctgcctcgagatagcgggttcaaccattgctgtctgaatgct
ccagttagtgcctgtgacccacaggatgacgtgcaacccccagaggtggaggaagaggag
gaggaggaggaggaggaaggggaggcagcaggggaaaacataggagaaaaaagtgaaagc
agagaagaaaagttaggagactcattgcaagatttatacagggcactggagcaggccagt
ctgtcaccactaggagaacatcgtatttcaaccaagatggaatacaagctatcatttata
aaaagatgtaatgatcctgtaatgaatgaaaaactacaccggctgagaattctcaaaagc
actttaaaggccagagaaggggaagtagccattatcgataaagtcctagacaatccagac
ttgacatctaaagaattccaacaatggaagcagatgtacctcgaccttttcttggatatc
tgtcaaaataccacctcaaatgacccactgagtatttcttctgaagtagatgtaatcact
tcctctctagcacacactcattcatacattgaaacgcatgtctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (45)   
   RefSeq(nuc) (11)   
   GenBank (17)   
   EMBL (17)   
3D Structure (2)   
   PDB (2)   
Protein domain (10)   
   Pfam (10)   
All databases (95)   

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