KEGG   Homo sapiens (human): 22894
Entry
22894             CDS       T01001                                 
Symbol
DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p
Name
(RefSeq) DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  KO
K12585  exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    22894 (DIS3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    22894 (DIS3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA degradation factors
   3'-5' decay
    Exosome cofactors
     22894 (DIS3)
SSDB
Motif
Pfam: RNB OB_Dis3 PIN_4 Rrp44_CSD1 Rrp44_S1 CSD2 Toxin_R_bind_C
Other DBs
NCBI-GeneID: 22894
NCBI-ProteinID: NP_055768
OMIM: 607533
HGNC: 20604
Ensembl: ENSG00000083520
UniProt: Q9Y2L1
Structure
Position
13:complement(72752169..72781900)
AA seq 958 aa
MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVC
PQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHF
YTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRN
KEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQG
IKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKS
QWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGML
SKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNL
GDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDP
PGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMV
PELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSA
NMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETN
SMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKS
LAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIR
RYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFF
KSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTV
FHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK
NT seq 2877 nt   +upstreamnt  +downstreamnt
atgctcaagtccaagacgttcttaaaaaagacccgggcgggcggcgtgatgaagatcgtg
cgcgagcactacctgcgagacgacatcggctgcggtgcgcccgggtgcgcagcgtgtgga
ggggcgcacgaggggccggccctggagccgcagccccaggacccggcgagcagcgtctgc
ccgcaaccgcactacttgctgcccgacactaatgtgttactgcaccagattgatgttctt
gaggaccctgccatcaggaatgtaattgtgctacaaacagttcttcaagaagtgagaaat
cgcagtgcccccgtatataaacgcatccgagatgtgactaataaccaagagaagcatttc
tatactttcactaatgagcaccatagagaaacctatgtagaacaagaacagggagaaaat
gctaatgacaggaatgatagagcgattcgagtagcagcaaaatggtacaatgaacatttg
aaaaaaatgtcagcagacaaccagctgcaagttatcttcataacaaatgacaggagaaac
aaagagaaagccatagaagaaggaataccagctttcacttgtgaagaatatgtaaagagc
ctaactgctaaccccgaactcatagatcgtcttgcttgtttgtctgaagaagggaatgaa
atagaaagtggaaaaataatattttcagagcatcttcccttaagtaagctacagcaaggc
ataaaatctggtacataccttcaaggaacatttagagctagcagggaaaattacttggaa
gctacagtatggattcatggcgacaatgaagaaaataaagagataatcttacagggactt
aaacatttaaacagagctgttcacgaagatattgtggctgtggagcttctccccaagagt
cagtgggtagcaccatcttctgtggttttacatgatgaaggtcaaaatgaagaagatgtg
gagaaagaagaagagacagaacgaatgcttaagactgctgtaagcgagaaaatgttgaag
cctacaggtagagttgtaggaataataaaaaggaattggagaccatattgtggcatgctt
tccaagtctgacattaaggagtcaagaagacatctctttacacctgctgataagagaatc
cctcgaattcgcatagaaaccagacaggcttccacattagaaggacggagaattattgtt
gctattgatggttggcccagaaattccagatatccaaatggacactttgtgagaaattta
ggtgatgttggagagaaagagactgaaacagaagttttgttacttgaacacgatgttccc
catcagcctttttcacaggctgttcttagttttctgccaaagatgccctggagcattact
gaaaaggacatgaaaaaccgagaagacctgaggcatctgtgtatttgtagtgtagaccca
ccaggatgtactgatatagacgatgctctacattgtcgagaactcgaaaatggaaatttg
gaggttggtgttcatattgctgatgtgagccattttattaggccaggaaatgccttggat
caagaatcagccagaagaggaacaactgtgtatctttgtgaaaagaggattgacatggtt
ccagagttgcttagctctaacttgtgttccttaaaatgtgacgtggacaggctggcattt
tcatgtatttgggaaatgaatcacaatgctgaaatcttaaaaacgaagtttaccaaaagt
gttattaattcaaaggcatctctgacgtatgctgaagctcagttgagaattgattcagca
aacatgaatgatgatattaccactagtctccgtggactgaataaactagccaaaattctg
aagaaaagaaggattgaaaaaggggctttgactctatcctctcctgaagttcgattccac
atggacagtgaaactcacgatcctatagatctgcagaccaaggaacttagggaaacaaat
tccatggttgaagaatttatgttacttgccaatatttctgttgcaaaaaaaattcatgag
gaattttctgaacatgctctgcttcgaaaacatcctgctccacctccatcaaattatgaa
attcttgttaaggcagccaggtcaaggaatttggaaattaagactgatacagccaagtct
ttggctgagtctttggatcaggccgaatctcctacttttccatatctaaacactctgttg
agaatattagccactcgctgtatgatgcaagctgtgtacttctgttctggaatggataat
gattttcatcactatggcttagcgtctccaatatacacacattttacttcacccattaga
agatacgcagatgtcattgttcatcggcttttggctgtggctattggggctgactgtact
tatccagagttgacagacaaacacaagcttgcagatatatgtaaaaatctaaatttccgg
cacaaaatggctcaatatgcccaacgtgcatcagtggcttttcatacccagttattcttc
aaaagcaaaggaatagtaagtgaagaagcctatattttatttgtaagaaagaatgccatt
gtggtattaattccaaagtatggtttagaagggacagtcttttttgaagaaaaggacaaa
ccaaacccacagcttatttatgatgatgagataccctcacttaaaatagaagatacagtg
ttccatgtatttgataaagttaaagtgaaaatcatgttagactcatctaatcttcaacat
cagaagatccgaatgtccctggtagaaccacagataccaggaataagcattcctactgat
acttcaaacatggaccttaatggaccaaagaaaaagaagatgaagcttggaaaatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (34)   
   RefSeq(nuc) (4)   
   GenBank (15)   
   EMBL (15)   
3D Structure (3)   
   PDB (3)   
Protein domain (7)   
   Pfam (7)   
All databases (72)   

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