KEGG   Homo sapiens (human): 22992
Entry
22992             CDS       T01001                                 
Symbol
KDM2A, CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA
Name
(RefSeq) lysine demethylase 2A
  KO
K10276  F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    22992 (KDM2A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    22992 (KDM2A)
   04121 Ubiquitin system [BR:hsa04121]
    22992 (KDM2A)
   03036 Chromosome and associated proteins [BR:hsa03036]
    22992 (KDM2A)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.27  [histone H3]-dimethyl-L-lysine36 demethylase
     22992 (KDM2A)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    22992 (KDM2A)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     22992 (KDM2A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    22992 (KDM2A)
   Polycomb repressive complex (PRC) and associated proteins
    Noncanonical PRC1 (PRC1.1)
     22992 (KDM2A)
SSDB
Motif
Pfam: PHD_4 zf-CXXC F-box-like JHD F-box JmjC Cupin_8 LRR_4 Cupin_1
Other DBs
NCBI-GeneID: 22992
NCBI-ProteinID: NP_036440
OMIM: 605657
HGNC: 13606
Ensembl: ENSG00000173120
UniProt: Q9Y2K7 I3VM53
Structure
Position
11:67119263..67258082
AA seq 1162 aa
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
NT seq 3489 nt   +upstreamnt  +downstreamnt
atggaacccgaagaagaaaggattcgttacagccagagattgcgtggtaccatgcgacga
cgctatgaagatgatggcatttcagatgatgaaattgaaggaaaaagaacttttgacttg
gaagagaaactgcacaccaacaaatataatgccaattttgttacttttatggaaggaaaa
gattttaatgtagagtatattcagcggggtggcttgagagatcctctgattttcaagaat
tctgatggactcggaataaaaatgccggatccagacttcactgtgaatgatgtcaaaatg
tgtgtggggagtcgtcgcatggtggatgtcatggacgtgaacacacagaaaggcattgaa
atgaccatggctcagtggacacgctactatgagaccccagaggaggagcgagagaaactc
tataatgtcatcagcctcgagtttagccacaccaggctggagaatatggtgcagaggccc
tccacggtggatttcattgactgggtagacaacatgtggccaaggcacttgaaggaaagc
cagactgaatcaacaaatgccatcttggagatgcagtaccctaaagtgcagaagtactgt
ctaatgagtgttcgaggctgctatactgacttccatgtggactttggtggtacctctgtt
tggtatcacatccatcaagggggaaaggtcttctggctcatcccccctacagcccacaac
ctggagctgtacgagaattggctgctgtcagggaaacagggagacatctttctgggtgac
cgggtatcagattgtcagcgcattgagctcaagcagggctataccttcgtcattccctca
ggctggattcatgctgtgtatactcctacagacacattagtgtttgggggcaattttttg
catagcttcaacatccctatgcagttaaaaatatacaacattgaagatcggacacgggtt
ccaaataagtttcgctatccattctactatgagatgtgttggtatgtgttggagcgctat
gtgtactgcataaccaaccgttcccacctaactaaggaatttcagaaagagtccctcagc
atggatttggagttaaatgggttggagtctgggaatggggatgaggaagcagtggatcga
gaaccccgacgcttgagcagcaggcgttctgtcctcactagccctgtagcgaatggagtc
aacctggattatgatggactgggcaaaacctgccgaagtcttccaagtctgaagaaaact
ttggctggggactcatcttctgactgtagccggggctcccacaatggacaagtgtgggat
ccccagtgtgctccccgaaaggacaggcaagtgcatctgacccattttgagcttgaaggc
cttcgctgccttgtagataagttggagtctctgccactgcacaagaaatgtgtccccaca
gggatagaagatgaagatgctctcattgctgatgtaaagattttgctggaggagcttgcc
aacagcgatcccaagttagccctcactggagttcctatagtacagtggccaaaaagggat
aagcttaaattccccactcggccaaaggtgcgggttcctaccatccccattacgaagcct
cacactatgaaaccagctccacggttaacacctgtgaggccagctgctgcctccccgatt
gtgtcaggagccagacggagacgagtgcgatgtcgaaaatgcaaagcctgtgtgcaagga
gagtgtggtgtttgccactactgcagagacatgaagaagtttggggggcctggacgcatg
aagcagtcctgtgtcctccgacagtgcttggcacccagactgcctcactcagtcacatgt
tccctctgtggagaggtggatcagaatgaagagacacaagactttgagaagaaactcatg
gaatgctgtatctgcaatgagattgttcatcctggctgcctccagatggacggagagggg
ttgcttaacgaagaattgccaaattgctgggaatgtccaaagtgctaccaggaggacagc
tcggagaaagcccagaagcggaaaatggaagagagtgacgaagaagctgtgcaagccaaa
gtcctgcggcccctgcggagctgcgatgagcctctcacgcccccgcctcattcacccact
tccatgctgcagctcatccatgacccggtttccccccggggtatggtgactcggtcatcc
cctggggctggccccagcgaccaccacagtgccagccgcgatgagcgcttcaaacggcgg
cagttgctgcggctgcaggccacagagcgcaccatggtacgggaaaaggagaacaatccc
agcggcaaaaaggagctgtctgaagttgagaaagccaagatccggggatcgtacctcact
gtcacgctacagaggcccaccaaagagctccacgggacatccattgtgcccaagctgcag
gccatcacggcctcctctgccaaccttcgccattccccccgtgtgctagtgcagcactgc
ccagcccgaaccccccagcgtggggatgaggaggggctggggggagaggaggaggaagag
gaggaggaggaggaggaagatgacagtgcagaggaggggggtgcagccaggctgaatggc
cggggcagttgggctcaggatggagacgaaagctggatgcagcgggaggtctggatgtct
gtcttccgctacctcagccgcagagaactttgtgaatgtatgcgagtgtgcaagacgtgg
tataaatggtgctgcgacaagagactttggacaaaaattgacttgagtaggtgtaaggcc
attgtgccccaggccctcagtggcatcatcaagaggcagccagtcagccttgacctcagt
tggaccaacatctctaaaaagcaactgacatggctcgtcaataggctgccaggactgaaa
gacctcctcctagcaggctgctcctggtctgcagtctctgccctcagcacctccagctgc
ccccttctcaggacccttgatcttcggtgggcagtaggaatcaaggaccctcaaattcgg
gacttgcttactccaccggctgataaaccaggtcaggacaatcgcagcaagctccggaac
atgaccgacttccggctggcaggccttgacatcacagatgccacgcttcgcctcataatt
cgccacatgcccctcctgtctcgactcgacctcagtcactgcagccaccttacagatcag
tcctccaatctactcactgctgtcgggtcttccactcgctactctctcacagagctcaat
atggcaggttgcaataaattgacagaccagaccctgatctacctacggcgcattgccaac
gtcaccttgatcgaccttcgaggatgcaagcagatcactcgaaaagcctgcgagcacttc
atctcagacttgtccatcaacagcctctactgcctgtctgacgagaagctgatacagaag
atcagctaa

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (24)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (15)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (55)   
   RefSeq(nuc) (13)   
   GenBank (21)   
   EMBL (21)   
3D Structure (6)   
   PDB (6)   
Protein domain (9)   
   Pfam (9)   
All databases (135)   

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