Entry |
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Symbol |
KDM1A, AOF2, BHC110, CPRF, KDM1, LSD1
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Name |
(RefSeq) lysine demethylase 1A
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KO |
K11450 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase [EC:1.14.99.66] |
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Organism |
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Pathway |
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Disease |
H02381 | Cleft palate, psychomotor retardation, and distinctive facial features |
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Drug target |
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Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09159 Environmental adaptation
04714 Thermogenesis
23028 (KDM1A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
23028 (KDM1A)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.99 Miscellaneous
1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase
23028 (KDM1A)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Histone modification proteins
HDAC complexes
BRAF-HDAC complex
23028 (KDM1A)
REST complex
23028 (KDM1A)
Histone demethylases
23028 (KDM1A)
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SSDB |
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Motif |
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Other DBs |
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Structure |
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Position |
1:23019468..23083689
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AA seq |
852 aa
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM |
NT seq |
2559 nt +upstreamnt +downstreamnt
atgttatctgggaagaaggcggcagccgcggcggcggcggctgcagcggcagcaaccggg
acggaggctggccctgggacagcaggcggctccgagaacgggtctgaggtggccgcgcag
cccgcgggcctgtcgggcccagccgaggtcgggccgggggcggtgggggagcgcacaccc
cgcaagaaagagcctccgcgggcctcgccccccgggggcctggcggaaccgccggggtcc
gcagggcctcaggccggccctactgtcgtgcctgggtctgcgacccccatggaaactgga
atagcagagactccggaggggcgtcggaccagccggcgcaagcgggcgaaggtagagtac
agagagatggatgaaagcttggccaacctctcagaagatgagtattattcagaagaagag
agaaatgccaaagcagagaaggaaaagaagcttcccccaccaccccctcaagccccacct
gaggaagaaaatgaaagtgagcctgaagaaccatcgggtgtggagggcgcagctttccag
agccgacttcctcatgaccggatgacttctcaagaagcagcctgttttccagatattatc
agtggaccacaacagacccagaaggtttttcttttcattagaaaccgcacactgcagttg
tggttggataatccaaagattcagctgacatttgaggctactctccaacaattagaagca
ccttataacagtgatactgtgcttgtccaccgagttcacagttatttagagcgtcatggt
cttatcaacttcggcatctataagaggataaaacccctaccaactaaaaagacaggaaag
gtaattattataggctctggggtctcaggcttggcagcagctcgacagttacaaagtttt
ggaatggatgtcacacttttggaagccagggatcgtgtgggtggacgagttgccacattt
cgcaaaggaaactatgtagctgatcttggagccatggtggtaacaggtcttggagggaat
cctatggctgtggtcagcaaacaagtaaatatggaactggccaagatcaagcaaaaatgc
ccactttatgaagccaacggacaagctgttcctaaagagaaagatgaaatggtagagcaa
gagtttaaccggttgctagaagctacatcttaccttagtcatcaactagacttcaatgtc
ctcaataataagcctgtgtcccttggccaggcattggaagttgtcattcagttacaagag
aagcatgtcaaagatgagcagattgaacattggaagaagatagtgaaaactcaggaagaa
ttgaaagaacttcttaataagatggtaaatttgaaagagaaaattaaagaactccatcag
caatacaaagaagcatctgaagtaaagccacccagagatattactgccgagttcttagtg
aaaagcaaacacagggatctgaccgccctatgcaaggaatatgatgaattagctgaaaca
caaggaaagctagaagaaaaacttcaggagttggaagcgaatcccccaagtgatgtatat
ctctcatcaagagacagacaaatacttgattggcattttgcaaatcttgaatttgctaat
gccacacctctctcaactctctcccttaagcactgggatcaggatgatgactttgagttc
actggcagccacctgacagtaaggaatggctactcgtgtgtgcctgtggctttagcagaa
ggcctagacattaaactgaatacagcagtgcgacaggttcgctacacggcttcaggatgt
gaagtgatagctgtgaatacccgctccacgagtcaaacctttatttataaatgcgacgca
gttctctgtacccttcccctgggtgtgctgaagcagcagccaccagccgttcagtttgtg
ccacctctccctgagtggaaaacatctgcagtccaaaggatgggatttggcaaccttaac
aaggtggtgttgtgttttgatcgggtgttctgggatccaagtgtcaatttgttcgggcat
gttggcagtacgactgccagcaggggtgagctcttcctcttctggaacctctataaagct
ccaatactgttggcactagtggcaggagaagctgctggtatcatggaaaacataagtgac
gatgtgattgttggccgatgcctggccattctcaaagggatttttggtagcagtgcagta
cctcagcccaaagaaactgtggtgtctcgttggcgtgctgatccctgggctcggggctct
tattcctatgttgctgcaggatcatctggaaatgactatgatttaatggctcagccaatc
actcctggcccctcgattccaggtgccccacagccgattccacgactcttctttgcggga
gaacatacgatccgtaactacccagccacagtgcatggtgctctgctgagtgggctgcga
gaagcgggaagaattgcagaccagtttttgggggccatgtatacgctgcctcgccaggcc
acaccaggtgttcctgcacagcagtccccaagcatgtga |