KEGG   Homo sapiens (human): 23030
Entry
23030             CDS       T01001                                 
Symbol
KDM4B, JMJD2B, MRD65, TDRD14B
Name
(RefSeq) lysine demethylase 4B
  KO
K06709  [histone H3]-trimethyl-L-lysine9/36 demethylase [EC:1.14.11.66 1.14.11.69]
Organism
hsa  Homo sapiens (human)
Disease
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23030 (KDM4B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.66  [histone H3]-trimethyl-L-lysine9 demethylase
     23030 (KDM4B)
    1.14.11.69  [histone H3]-trimethyl-L-lysine36 demethylase
     23030 (KDM4B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    23030 (KDM4B)
SSDB
Motif
Pfam: JmjC zf-HC5HC2H_2 Tudor_2 zf-HC5HC2H PHD_2 JmjN PHD LBR_tudor DUF4537 SLX1_C
Other DBs
NCBI-GeneID: 23030
NCBI-ProteinID: NP_055830
OMIM: 609765
HGNC: 29136
Ensembl: ENSG00000127663
UniProt: O94953 A0A0C4DFL8
Structure
Position
19:4969113..5153598
AA seq 1096 aa
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY
DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER
KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR
HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY
GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE
EEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW
LPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF
SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQW
KNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN
EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDI
SAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDN
LYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKR
GDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVA
FVESLLQVQGRPGAPF
NT seq 3291 nt   +upstreamnt  +downstreamnt
atggggtctgaggaccacggcgcccagaaccccagctgtaaaatcatgacgtttcgccca
accatggaagaatttaaagacttcaacaaatacgtggcctacatagagtcgcagggagcc
caccgggcgggcctggccaagatcatccccccgaaggagtggaagccgcggcagacgtat
gatgacatcgacgacgtggtgatcccggcgcccatccagcaggtggtgacgggccagtcg
ggcctcttcacgcagtacaatatccagaagaaggccatgacagtgggcgagtaccgccgc
ctggccaacagcgagaagtactgtaccccgcggcaccaggactttgatgaccttgaacgc
aaatactggaagaacctcacctttgtctccccgatctacggggctgacatcagcggctct
ttgtatgatgacgacgtggcccagtggaacatcgggagcctccggaccatcctggacatg
gtggagcgcgagtgcggcaccatcatcgagggcgtgaacacgccctacctgtacttcggc
atgtggaagaccaccttcgcctggcacaccgaggacatggacctgtacagcatcaactac
ctgcactttggggagcctaagtcctggtacgccatcccaccagagcacggcaagcgcctg
gagcggctggccatcggcttcttccccgggagctcgcagggctgcgacgccttcctgcgg
cataagatgaccctcatctcgcccatcatcctgaagaagtacgggatccccttcagccgg
atcacgcaggaggccggggaattcatgatcacatttccctacggctaccacgccggcttc
aatcacgggttcaactgcgcagaatctaccaacttcgccaccctgcggtggattgactac
ggcaaagtggccactcagtgcacgtgccggaaggacatggtcaagatctccatggacgtg
ttcgtgcgcatcctgcagcccgagcgctacgagctgtggaagcagggcaaggacctcacg
gtgctggaccacacgcggcccacggcgctcaccagccccgagctgagctcctggagtgca
tcccgggcctcgctgaaggccaagctcctccgcaggtctcaccggaaacggagccagccc
aagaagccgaagcccgaagaccccaagttccctggggagggtacggctggggcagcgctc
ctagaggaggctgggggcagcgtgaaggaggaggctgggccggaggttgaccccgaggag
gaggaggaggagccgcagccactgccacacggccgggaggccgagggcgcagaagaggac
gggaggggcaagctgcggccaaccaaggccaagagcgagcggaagaagaagagcttcggc
ctgctgcccccacagctgccgcccccgcctgctcacttcccctcagaggaggcgctgtgg
ctgccatccccactggagcccccggtgctgggcccaggccctgcagccatggaggagagc
cccctgccggcaccccttaatgtcgtgccccctgaggtgcccagtgaggagctagaggcc
aagcctcggcccatcatccccatgctgtacgtggtgccgcggccgggcaaggcagccttc
aaccaggagcacgtgtcctgccagcaggcctttgagcactttgcccagaagggtccgacc
tggaaggaaccagtttcccccatggagctgacggggccagaggacggtgcagccagcagt
ggggcaggtcgcatggagaccaaagcccgggccggagaggggcaggcaccgtccacattt
tccaaattgaagatggagatcaagaagagccggcgccatcccctgggccggccgcccacc
cggtccccactgtcggtggtgaagcaggaggcctcaagtgacgaggaggcatcccctttc
tccggggaggaagatgtgagtgacccggacgccttgaggccgctgctgtctctgcagtgg
aagaacagggcggccagcttccaggccgagaggaagttcaacgcagcggctgcgcgcacg
gagccctactgcgccatctgcacgctcttctacccctactgccaggccctacagactgag
aaggaggcacccatagcctccctcggagagggctgcccggccacattaccctccaaaagc
cgtcagaagacccgaccgctcatccctgagatgtgcttcacctctggcggtgagaacacg
gagccgctgcctgccaactcctacatcggcgacgacgggaccagccccctgatcgcctgc
ggcaagtgctgcctgcaggtccatgccagttgctatggcatccgtcccgagctggtcaat
gaaggctggacgtgttcccggtgcgcggcccacgcctggactgcggagtgctgcctgtgc
aacctgcgaggaggtgcgctgcagatgaccaccgataggaggtggatccacgtgatctgt
gccatcgcagtccccgaggcgcgcttcctgaacgtgattgagcgccaccctgtggacatc
agcgccatccccgagcagcggtggaagctgaaatgcgtgtactgccggaagcggatgaag
aaggtgtcaggtgcctgtatccagtgctcctacgagcactgctccacgtccttccacgtg
acctgcgcccacgccgcaggcgtgctcatggagccggacgactggccctatgtggtctcc
atcacctgcctcaagcacaagtcggggggtcacgctgtccaactcctgagggccgtgtcc
ctaggccaggtggtcatcaccaagaaccgcaacgggctgtactaccgctgtcgcgtcatc
ggtgccgcctcgcagacctgctacgaagtgaacttcgacgatggctcctacagcgacaac
ctgtaccctgagagcatcacgagtagggactgtgtccagctgggacccccttccgagggg
gagctggtggagctccggtggactgacggcaacctctacaaggccaagttcatctcctcc
gtcaccagccacatctaccaggtggagtttgaggacgggtcccagctgacggtgaagcgt
ggggacatcttcaccctggaggaggagctgcccaagagggtccgctctcggctgtcactg
agcacgggggcaccgcaggagcccgccttctcgggggaggaggccaaggccgccaagcgc
ccgcgtgtgggcaccccgcttgccacggaggactccgggcggagccaggactacgtggcc
ttcgtggagagcctcctgcaggtgcagggccggcccggagcccccttctag

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   RefGene (28)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (30)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (27)   
DNA sequence (57)   
   RefSeq(nuc) (29)   
   GenBank (14)   
   EMBL (14)   
3D Structure (3)   
   PDB (3)   
Protein domain (10)   
   Pfam (10)   
All databases (145)   

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