KEGG   Homo sapiens (human): 23072
Entry
23072             CDS       T01001                                 
Symbol
HECW1, NEDL1
Name
(RefSeq) HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  KO
K12167  E3 ubiquitin-protein ligase HECW1 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    23072 (HECW1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     23072 (HECW1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   23072 (HECW1)
SSDB
Motif
Pfam: HECT HECW_N HECW1_helix WW C2 Keratin_B2_2 RFXA_RFXANK_bdg
Other DBs
NCBI-GeneID: 23072
NCBI-ProteinID: NP_055867
OMIM: 610384
HGNC: 22195
Ensembl: ENSG00000002746
UniProt: Q76N89
Structure
Position
7:43112647..43566001
AA seq 1606 aa
MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG
VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV
LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK
NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI
FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK
LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE
SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAA
VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA
STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS
ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL
SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS
SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS
SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV
ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID
SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED
SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN
PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL
PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS
EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA
RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC
SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL
EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN
DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL
EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI
ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE
YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE
KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE
NT seq 4821 nt   +upstreamnt  +downstreamnt
atgctgctgcacctgtgtagtgtgaagaatctgtaccagaacaggtttttaggcctggcc
gccatggcgtctccttctagaaactcccagagccgacgccggtgcaaggagccgctccga
tacagctacaaccccgaccagttccacaacatggacctcaggggcggcccccacgatggc
gtcaccattccccgctccaccagcgacactgacctggtcacctcggacagccgctccacg
ctcatggtcagcagctcctactattccatcgggcactctcaggacctggtcatccactgg
gacataaaggaggaagtggacgctggggactggattggcatgtacctcattgatgaggtc
ttgtccgaaaactttctggactataaaaaccgtggagtcaatggttctcatcggggccag
atcatctggaagatcgatgccagctcgtactttgtggaacctgaaactaagatctgcttc
aaatactaccatggagtgagtggggccctgcgagcaaccacccccagtgtcacggtcaaa
aactcggcagctcctatttttaaaagcattggtgctgatgagaccgtccaaggacaagga
agtcggaggctgatcagcttctctctctcagatttccaagccatggggttgaagaaaggg
atgtttttcaacccagacccttatctgaagatttccattcagcctgggaaacacagcatc
ttccccgccctccctcaccatggacaggagaggagatccaagatcataggcaacaccgtg
aaccccatctggcaggccgagcaattcagttttgtgtccttgcccactgacgtgctggaa
attgaggtgaaggacaagtttgccaagagccgccccatcatcaagcgcttcttgggaaag
ctgtcgatgcccgttcaaagactcctggagagacacgccataggggatagggtggtcagc
tacacacttggccgcaggcttccaacagatcatgtgagtggacagctgcaattccgattt
gagatcacttcctccatccacccagatgatgaggagatttccctgagtaccgagcctgag
tcagcccaaattcaggacagccccatgaacaacctgatggaaagcggcagtggggaacct
cggtctgaggcaccagagtcctctgagagctggaagccagagcagctgggtgagggcagt
gtccccgatggtccagggaaccaaagcatagagctttccagaccagctgaggaagcagca
gtcatcacggaggcaggagaccagggcatggtctctgtgggacctgaaggggctggggag
ctcctggcccaggtgcaaaaggacatccagcctgcccccagtgcagaagagctggccgag
cagctggacctgggtgaggaggcatcagcactgctgctggaagacggtgaagccccagcc
agcaccaaggaggagcccttggaggaggaagcaacgacccagagccgggctggaagggaa
gaagaggagaaggagcaggaggaggagggagatgtgtctaccctggagcagggagagggc
aggctgcagctgcgggcctcggtgaagagaaaaagcaggccctgctccttgcctgtgtcc
gagctggagacggtgatcgcgtcagcctgcggggaccccgagaccccgcggacacactac
atccgcatccacaccctgctgcacagcatgccctccgcccagggcggcagcgcggcagag
gaggaggacggcgcggaggaggagtccaccctcaaggactcctcggagaaggatgggctc
agcgaggtggacacggtggccgctgacccgtctgccctggaagaggacagagaagagccc
gagggggctactccaggcacggcgcaccctggccactccgggggccacttccccagcctg
gccaatggcgcggcccaggatggcgacacgcaccccagcaccgggagcgagagcgactcc
agccccaggcaaggcggggaccacagttgcgagggctgtgacgcgtcctgctgcagcccc
tcgtgctacagctcctcgtgctacagcacgtcctgctacagcagctcgtgctacagcgcc
tcgtgctacagcccctcctgctacaacggcaacaggttcgccagccacacgcgcttctcc
tccgtggacagcgccaagatctccgagagcacggtcttctcctcgcaagacgacgaggag
gaggagaacagcgcgttcgagtcggtacccgactccatgcagagccctgagctggacccg
gagtccacgaacggcgctgggccgtggcaagacgagctggccgcccctagcgggcacgtg
gaaagaagcccggaaggtctggaatcccccgtggcaggtccaagcaatcggagagaaggt
gaatgtcctatactccataattcccagccagtaagccagcttccttccctgaggcctgaa
catcatcactacccaacaatcgatgagcctcttccaccaaactgggaagctcgaattgac
agccacgggcgggtcttttatgtggaccacgtgaaccgcacaaccacctggcagcgtccg
acggcagcagccaccccggatggcatgcggagatcggggtccatccagcagatggagcaa
ctcaacaggcggtatcaaaacattcagcgaaccattgcaacagagaggtccgaagaagat
tctggcagccaaagctgcgagcaagccccagcaggaggaggcggaggtggagggagtgac
tcagaagccgaatcttcccagtccagcttagatctaaggagagaagggtcactttctcca
gtgaactcacaaaaaatcaccttgctgctgcagtccccagcggtcaagttcatcaccaac
cccgagttcttcactgtgctacatgccaattatagtgcctaccgagtcttcaccagtagc
acctgcttaaagcacatgattctgaaagtccgacgggatgctcgcaattttgaacgctac
cagcacaaccgggacttggtgaatttcatcaacatgttcgcagacactcggctggaactg
ccccggggctgggagatcaaaacggaccagcagggaaagtcttttttcgtggaccacaac
agtcgagctaccactttcattgacccccgaatccctcttcagaacggtcgtcttcccaat
catctaactcaccgacagcacctccagaggctccgaagttacagcgctggagaggcctca
gaagtttctagaaacagaggagcctctttactggccaggccaggacacagcttagtagct
gctattcgaagccaacatcaacatgagtcattgccactggcatataatgacaagattgtg
gcatttcttcgccagccaaacatttttgaaatgctgcaagagcgtcagccaagcttagca
agaaaccacacactcagggagaaaatccattacattcggactgagggtaatcacgggctt
gagaagttgtcctgtgatgcggatctggtcattttgctgagtctctttgaagaagagatt
atgtcctacgtccccctgcaggctgccttccaccctgggtatagcttctctccccgatgt
tcaccctgttcttcacctcagaactccccaggtttacagagagccagtgcaagagcccct
tccccctaccgaagagactttgaggccaagctccgcaatttctacagaaaactggaagcc
aaaggatttggtcagggtccggggaaaattaagctcattattcgccgggatcatttgttg
gagggaaccttcaatcaggtgatggcctattcgcggaaagagctccagcgaaacaagctc
tacgtcacctttgttggagaggagggcctggactacagtggcccctcgcgggagttcttc
ttccttctgtctcaggagctcttcaacccttactatggactctttgagtactcggcaaat
gatacttacacggtgcagatcagccccatgtccgcatttgtagaaaaccatcttgagtgg
ttcaggtttagcggtcgcatcctgggtctggctctgatccatcagtaccttcttgacgct
ttcttcacgaggcccttctacaaggcactcctgagactgccctgtgatttgagtgacctg
gaatatttggatgaggaattccaccagagtttgcagtggatgaaggacaacaacatcaca
gacatcttagacctcactttcactgttaatgaagaggtttttggacaggtcacggaaagg
gagttgaagtctggaggagccaacacacaggtgacggagaaaaacaagaaggagtacatc
gagcgcatggtgaagtggcgggtggagcgcggcgtggtacagcagaccgaggcgctggtg
cgcggcttctacgaggttgtagactcgaggctggtgtccgtgtttgatgccagggagctg
gagctggtgatagctggcaccgcggaaatcgacctaaatgactggcggaataacactgag
taccggggaggttaccacgatgggcatcttgtgatccgctggttctgggctgcggtggag
cgcttcaataatgagcagaggctgagattactgcagtttgtcacgggaacatccagcgtg
ccctacgaaggcttcgcagccctccgtgggagcaatgggcttcggcgcttctgcatagag
aaatgggggaaaattacttctctccccagggcacacacatgcttcaaccgactggatctt
ccaccgtatccctcgtactccatgttgtatgaaaagctgttaacagcagtagaggaaacc
agcacctttggacttgagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (38)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (36)   
DNA sequence (52)   
   RefSeq(nuc) (36)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (7)   
   Pfam (7)   
All databases (137)   

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