KEGG   Homo sapiens (human): 231
Entry
231               CDS       T01001                                 
Symbol
AKR1B1, ADR, ALDR1, ALR2, AR
Name
(RefSeq) aldo-keto reductase family 1 member B
  KO
K00011  aldehyde reductase [EC:1.1.1.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00040  Pentose and glucuronate interconversions
hsa00051  Fructose and mannose metabolism
hsa00052  Galactose metabolism
hsa00561  Glycerolipid metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
Drug target
Alrestatin sodium: D02835
Caficrestat: D12390
Epalrestat: D01688<JP>
Fidarestat: D01842
Govorestat: D12384
Lidorestat: D03803
Minalrestat: D03805
Ponalrestat: D03806
Ranirestat: D06403
Risarestat: D01715
Sorbinil: D05893
Tolrestat: D02323
Zenarestat: D03807
Zopolrestat: D02328
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    231 (AKR1B1)
   00051 Fructose and mannose metabolism
    231 (AKR1B1)
   00052 Galactose metabolism
    231 (AKR1B1)
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    231 (AKR1B1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    231 (AKR1B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.21  aldose reductase
     231 (AKR1B1)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 231
NCBI-ProteinID: NP_001619
OMIM: 103880
HGNC: 381
Ensembl: ENSG00000085662
UniProt: P15121
Structure
Position
7:complement(134442350..134459239)
AA seq 316 aa
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
NT seq 951 nt   +upstreamnt  +downstreamnt
atggcaagccgtctcctgctcaacaacggcgccaagatgcccatcctggggttgggtacc
tggaagtcccctccagggcaggtgactgaggccgtgaaggtggccattgacgtcgggtac
cgccacatcgactgtgcccatgtgtaccagaatgagaatgaggtgggggtggccattcag
gagaagctcagggagcaggtggtgaagcgtgaggagctcttcatcgtcagcaagctgtgg
tgcacgtaccatgagaagggcctggtgaaaggagcctgccagaagacactcagcgacctg
aagctggactacctggacctctaccttattcactggccgactggctttaagcctgggaag
gaatttttcccattggatgagtcgggcaatgtggttcccagtgacaccaacattctggac
acgtgggcggccatggaagagctggtggatgaagggctggtgaaagctattggcatctcc
aacttcaaccatctccaggtggagatgatcttaaacaaacctggcttgaagtataagcct
gcagttaaccagattgagtgccacccatatctcactcaggagaagttaatccagtactgc
cagtccaaaggcatcgtggtgaccgcctacagccccctcggctctcctgacaggccctgg
gccaagcccgaggacccttctctcctggaggatcccaggatcaaggcgatcgcagccaag
cacaataaaactacagcccaggtcctgatccggttccccatgcagaggaacttggtggtg
atccccaagtctgtgacaccagaacgcattgctgagaactttaaggtctttgactttgaa
ctgagcagccaggatatgaccaccttactcagctacaacaggaactggagggtctgtgcc
ttgttgagctgtacctcccacaaggattaccccttccatgaagagttttga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Drug (14)   
   KEGG DRUG (14)   
Chemical substance (22)   
   KEGG COMPOUND (22)   
Chemical reaction (13)   
   KEGG ENZYME (1)   
   KEGG REACTION (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (18)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (39)   
   RefSeq(nuc) (3)   
   GenBank (18)   
   EMBL (18)   
3D Structure (167)   
   PDB (167)   
Protein domain (1)   
   Pfam (1)   
All databases (299)   

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