KEGG   Homo sapiens (human): 23135
Entry
23135             CDS       T01001                                 
Symbol
KDM6B, JMJD3, NEDCFSA, NEDSST
Name
(RefSeq) lysine demethylase 6B
  KO
K11448  lysine-specific demethylase 6B [EC:1.14.11.68]
Organism
hsa  Homo sapiens (human)
Disease
H02460  Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23135 (KDM6B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.68  [histone H3]-trimethyl-L-lysine27 demethylase
     23135 (KDM6B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    23135 (KDM6B)
SSDB
Motif
Pfam: JmjC KDM6_C-hel KDM6_GATAL
Other DBs
NCBI-GeneID: 23135
NCBI-ProteinID: NP_001335645
OMIM: 611577
HGNC: 29012
Ensembl: ENSG00000132510
UniProt: O15054
Structure
Position
17:7834217..7854796
AA seq 1643 aa
MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPL
PPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESE
HDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLL
HLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGL
PPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPP
ERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDL
RESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIP
GADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPP
PPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDS
HTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLV
PLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGV
GELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVA
PQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPP
LAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPG
PPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPP
PLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAKE
EAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGN
LDLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPG
PPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAA
DVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPV
LLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLT
GTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDP
KNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYM
KVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPI
LDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERY
EWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKK
IAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLE
QYRTEELAQAYDAFTLAPASTSR
NT seq 4932 nt   +upstreamnt  +downstreamnt
atgcatcgggcagtggaccctccaggggcccgcgctgcacgggaagcctttgcccttggg
ggcctgagctgtgctggggcctggagctcctgcccgcctcatccccctcctcgtagcgca
tggctgcctggaggcagatgctcagccagcattgggcagcccccgcttcctgctccccta
cccccttcacatggcagtagttctgggcaccccagcaaaccatattatgctccaggggcg
cccactccaagacccctccatgggaagctggaatccctgcatggctgtgtgcaggcattg
ctccgggagccagcccagccagggctttgggaacagcttgggcaactgtacgagtcagag
cacgatagtgaggaggccacacgctgctaccacagcgcccttcgatacggaggaagcttc
gctgagctggggccccgcattggccgactgcagcaggcccagctctggaactttcatact
ggctcctgccagcaccgagccaaggtcctgcccccactggagcaagtgtggaacttgcta
caccttgagcacaaacggaactatggagccaagcggggaggtcccccggtgaagcgagct
gctgaacccccagtggtgcagcctgtgcctcctgcagcactctcaggcccctcaggggag
gagggcctcagccctggaggcaagcgaaggagaggctgcaactctgaacagactggcctt
cccccagggctgccactgcctccaccaccattaccaccaccaccaccaccaccaccacca
ccaccaccacccctgcctggcctggctaccagccccccatttcagctaaccaagccaggg
ctgtggagtaccctgcatggagatgcctggggcccagagcgcaagggttcagcaccccca
gagcgccaggagcagcggcactcgctgcctcacccatatccatacccagctccagcgtac
accgcgcacccccctggccaccggctggtcccggctgctcccccaggcccaggcccccgc
cccccaggagcagagagccatggctgcctgcctgccacccgtccccccggaagtgacctt
agagagagcagagttcagaggtcgcggatggactccagcgtttcaccagcagcaaccacc
gcctgcgtgccttacgccccttcccggccccctggcctccccggcaccaccaccagcagc
agcagtagcagcagcagcaacactggtctccggggcgtggagccgaacccaggcattccc
ggcgctgaccattaccaaactcccgcgctggaggtctctcaccatggccgcctggggccc
tcggcacacagcagtcggaaaccgttcttgggggctcccgctgccactccccacctatcc
ctgccacctggaccttcctcaccccctccacccccctgtccccgcctcttacgcccccca
ccaccccctgcctggttgaagggtccggcctgccgggcagcccgagaggatggagagatc
ttagaagagctcttctttgggactgagggacccccccgccctgccccaccacccctcccc
catcgcgagggcttcttggggcctccggcctcccgcttttctgtgggcactcaggattct
cacacccctcccactcccccaaccccaaccaccagcagtagcaacagcaacagtggcagc
cacagcagcagccctgctgggcctgtgtcctttcccccaccaccctatctggccagaagt
atagacccccttccccggcctcccagcccagcacagaacccccaggacccacctcttgta
cccctgactcttgccctgcctccagcccctccttcctcctgccaccaaaatacctcagga
agcttcaggcgcccggagagcccccggcccagggtctccttcccaaagacccccgaggtg
gggccggggccacccccaggccccctgagtaaagccccccagcctgtgccgcccggggtt
ggggagctgcctgcccgaggccctcgactctttgattttccccccactccgctggaggac
cagtttgaggagccagccgaattcaagatcctacctgatgggctggccaacatcatgaag
atgctggacgaatccattcgcaaggaagaggaacagcaacaacacgaagcaggcgtggcc
ccccaacccccgctgaaggagccctttgcatctctgcagtctcctttccccaccgacaca
gcccccaccactactgctcctgctgtcgccgtcaccaccaccaccaccaccaccaccacc
accacggccacccaggaagaggagaagaagccaccaccagccctaccaccaccaccgcct
ctagccaagttccctccaccctctcagccacagccaccaccacccccaccccccagcccg
gccagcctgctcaaatccttggcctccgtgctggagggacaaaagtactgttatcggggg
actggagcagctgtttccacccggcctgggcccttgcccaccactcagtattcccctggc
cccccatcaggtgctaccgccctgccgcccacctcagcggcccctagcgcccagggctcc
ccacagccctctgcttcctcgtcatctcagttctctacctcaggcgggccctgggcccgg
gagcgcagggcgggcgaagagccagtcccgggccccatgacccccacccaaccgccccca
cccctatctctgccccctgctcgctctgagtctgaggtgctagaagagatcagccgggct
tgcgagacccttgtggagcgggtgggccggagtgccactgacccagccgacccagtggac
acagcagagccagcggacagtgggactgagcgactgctgccccccgcacaggccaaggag
gaggctggcggggtggcggcagtgtcaggcagctgtaagcggcgacagaaggagcatcag
aaggagcatcggcggcacaggcgggcctgtaaggacagtgtgggtcgtcggccccgtgag
ggcagggcaaaggccaaggccaaggtccccaaagaaaagagccgccgggtgctggggaac
ctggacctgcagagcgaggagatccagggtcgtgagaagtcccggcccgatcttggcggg
gcctccaaggccaagccacccacagctccagcccctccatcagctcctgcaccttctgcc
cagcccacacccccgtcagcctctgtccctggaaagaaggctcgggaggaagccccaggg
ccaccgggtgtcagccgggccgacatgctgaagctgcgctcacttagtgaggggcccccc
aaggagctgaagatccggctcatcaaggtagagagtggtgacaaggagacctttatcgcc
tctgaggtggaagagcggcggctgcgcatggcagacctcaccatcagccactgtgctgct
gacgtcgtgcgcgccagcaggaatgccaaggtgaaagggaagtttcgagagtcctacctt
tcccctgcccagtctgtgaaaccgaagatcaacactgaggagaagctgccccgggaaaaa
ctcaacccccctacacccagcatctatctggagagcaaacgggatgccttctcacctgtc
ctgctgcagttctgtacagaccctcgaaatcccatcacagtgatccggggcctggcgggc
tccctgcggctcaacttgggcctcttctccaccaagaccctggtggaagcgagtggcgaa
cacaccgtggaagttcgcacccaggtgcagcagccctcagatgagaactgggatctgaca
ggcactcggcagatctggccttgtgagagctcccgttcccacaccaccattgccaagtac
gcacagtaccaggcctcatccttccaggagtctctgcaggaggagaaggagagtgaggat
gaggagtcagaggagccagacagcaccactggaacccctcctagcagcgcaccagacccg
aagaaccatcacatcatcaagtttggcaccaacatcgacttgtctgatgctaagcggtgg
aagccccagctgcaggagctgctgaagctgcccgccttcatgcgggtaacatccacgggc
aacatgctgagccacgtgggccacaccatcctgggcatgaacacggtgcagctgtacatg
aaggtgcccggcagccgaacgccaggccaccaggagaataacaacttctgctccgtcaac
atcaacattggcccaggcgactgcgagtggttcgcggtgcacgagcactactgggagacc
atcagcgctttctgtgatcggcacggcgtggactacttgacgggttcctggtggccaatc
ctggatgatctctatgcatccaatattcctgtgtaccgcttcgtgcagcgacccggagac
ctcgtgtggattaatgcggggactgtgcactgggtgcaggccaccggctggtgcaacaac
attgcctggaacgtggggcccctcaccgcctatcagtaccagctggccctggaacgatac
gagtggaatgaggtgaagaacgtcaaatccatcgtgcccatgattcacgtgtcatggaac
gtggctcgcacggtcaaaatcagcgaccccgacttgttcaagatgatcaagttctgcctg
ctgcagtccatgaagcactgccaggtgcaacgcgagagcctggtgcgggcagggaagaaa
atcgcttaccagggccgtgtcaaggacgagccagcctactactgcaacgagtgcgatgtg
gaggtgtttaacatcctgttcgtgacaagtgagaatggcagccgcaacacgtacctggta
cactgcgagggctgtgcccggcgccgcagcgcaggcctgcagggcgtggtggtgctggag
cagtaccgcactgaggagctggctcaggcctacgacgccttcacgctggccccagccagc
acgtcgcgatga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (83)   
   KEGG ORTHOLOGY (1)   
   RefGene (76)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (10)   
   RefSeq(nuc) (2)   
   GenBank (4)   
   EMBL (4)   
3D Structure (6)   
   PDB (6)   
Protein domain (3)   
   Pfam (3)   
All databases (114)   

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