KEGG   Homo sapiens (human): 23239
Entry
23239             CDS       T01001                                 
Symbol
PHLPP1, PHLPP, PLEKHE1, PPM3A, SCOP
Name
(RefSeq) PH domain and leucine rich repeat protein phosphatase 1
  KO
K16340  PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04151  PI3K-Akt signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    23239 (PHLPP1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    23239 (PHLPP1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     23239 (PHLPP1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
   PPM1 phosphatases (PP2C)
    23239 (PHLPP1)
SSDB
Motif
Pfam: LRR_8 PP2C LRR_4 LRR_6 PH
Other DBs
NCBI-GeneID: 23239
NCBI-ProteinID: NP_919431
OMIM: 609396
HGNC: 20610
Ensembl: ENSG00000081913
UniProt: O60346
Position
18:62715541..62980433
AA seq 1717 aa
MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP
SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL
LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK
HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK
GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA
DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS
DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP
RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT
RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLS
GMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKHQH
CLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQ
DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN
VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLE
KLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRD
NKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMD
VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE
RTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT
NNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM
NCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPR
LVLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCD
NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQK
LGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIK
QHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSL
SVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAV
PPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP
GALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNG
SRVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKADFSAVGTIGR
RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKH
HQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL
NT seq 5154 nt   +upstreamnt  +downstreamnt
atggagcccgccgccgcggccacggtacagcgactccccgagctcggcagggaggaccga
gcttcggctccggcggccgccgctgcggcagcagcagcagcagcggcggccgcggcggct
ctggcggcggcggccgggggcggccggagtccggagcccgcgctgaccccggcggccccg
agcggcgggaacggcagcggcagcggggcgcgggaagaggccccaggcgaggcgccgccg
gggccgctgccgggcagagcggggggtgccgggcgcaggaggcggcgcggggcgccccag
cccattgccggcggggctgcccccgtacccggggccggcggcggcgccaactccctcctg
ctgaggagagggcggctgaagaggaatctgtccgcggccgccgcggccgcctcctcgtcg
tcgtcgtcctcggccgctgctgcctcgcactcccccggcgctgccggcctccccgcctcc
tgctcggcctcggcgtcgctgtgcacccggagcctggacaggaagacgctgcttctgaag
caccggcagacgctgcagctgcagccgtcggaccgggactgggtgaggcaccagctccag
cgcggctgcgtgcacgtcttcgaccgccacatggcctcgacctacctgcgcccggtgctc
tgcacactggacaccacggccggcgaggtggccgcccgcctgctgcagctgggccacaaa
ggcggcggcgtggtgaaggtgctgggccaggggcccggagccgccgccgcccgggagccc
gctgaaccgccccccgaggccggcccccggctggcgcccccggagccgcgggactcggag
gtaccgcccgcgaggagcgcgccgggtgccttcggggggcctccgcgcgcgccccccgcc
gacctacccctgcccgtcggcggcccgggcgggtggtcgcgccgcgccagcccagcgccc
tcggactccagccccggcgagccgttcgttgggggccctgtctcttcgccccgcgcccca
cggcctgtggtctccgacaccgagagcttcagtctgagtcccagcgccgagagcgtgtct
gaccggttggacccctacagcagcggcggcggctcctcgtcgtcgtcggaagagctcgag
gccgacgcagcctcggccccgacgggggtcccgggccagccccgccgtcccggccacccc
gcgcagcccctcccgcttccccagacggcttcctcgcctcagccgcagcagaaagccccg
agggccattgacagcccgggcggggccgtccgcgaggggtcgtgcgaggagaaggcagcg
gcagccgtggccccgggaggcctccagtctacccccgggaggagcggggtgaccgcggag
aaggcgcctccgccgcccccgccgcccaccctgtacgtgcagctccacggagagaccacc
cggcgcttggaggcggaggagaagccattgcagatccaaaatgactacctcttccaactg
ggatttggggagctgtggagggtgcaggaggaaggcatggactcggagattggctgcctc
atccgcttctatgcaggaaaacctcacagcacgggtagctctgaacggattcagctctca
ggaatgtataatgtccgtaaaggcaagatgcagttgccagtgaaccgatggacaagacgc
caagtcatcctatgtgggacctgcctgatagtatcatctgtgaaagacagcttgaccgga
aagatgcatgttctgccactaattggtggaaaagtagaagaagtgaaaaagcaccaacac
tgtttagcatttagctcctctggaccccaaagccagacttactacatttgctttgatact
ttcacagaatacttaaggtggctgcgacaagtctccaaggttgcatcccagcgcattagc
tcagtggacctctcgtgttgtagcctggaacatctgcctgccaacctcttctacagccaa
gacctcactcatctcaatttaaaacaaaacttcctaaggcagaaccctagccttccagct
gccagggggcttaatgaactgcaaaggttcaccaagttgaagagtcttaacctttccaat
aatcatttaggggacttcccactggcagtctgcagtattccaaccctggcagagctgaac
gtgtcctgcaatgccctgcgatcagtcccggcagccgttggagtgatgcacaacttacag
acatttttgttggatggaaactttctccaatcccttcctgctgagttggagaacatgaag
cagcttagttatctgggtctttctttcaatgaatttactgacattcccgaagtattggag
aaattgactgctgtggataaactttgtatgtctggaaactgtgtggagacccttaggcta
caggctttaagaaaaatgcctcacattaaacatgtggatctaaggttgaacgtaattagg
aagctgatagcagatgaagtggactttctacagcatgttactcagcttgacctacgagac
aataagcttggtgatctagatgctatgattttcaacaacattgaagttttacactgtgaa
aggaatcaactggtcacattagacatctgtggctatttcctaaaagcgctctatgcctct
tctaatgaacttgttcaacttgatgtttacccagttccaaattatctgtcctacatggat
gtttcaaggaaccgcttagaaaatgtgcctgagtgggtatgtgaaagccgaaagctagaa
gttttggatattggccataatcaaatatgtgaacttcctgcccgcttattttgtaatagc
agtctccggaaactactggcaggacacaaccagttggcaaggctgcctgaaaggctagaa
agaacctcggtggaggtcttggatgtgcaacacaaccagctccttgagctcccacctaac
cttctgatgaaggctgacagcctgagattcctgaacgcctctgcgaacaaactggaaagc
cttcctccagccacgctttccgaagagacaaacagtatcttacaagagttgtatttgaca
aataacagcctcacagacaaatgtgtgcccttgttaacgggacacccccatttgaagatc
cttcacatggcctataaccgacttcagagttttccagcaagtaaaatggcgaaactggag
gaacttgaagaaattgatctcagtgggaataagctgaaagccatcccaacaacgatcatg
aattgcaggcgcatgcacaccgtgattgctcactccaactgcatcgaggtctttcccgaa
gttatgcagctcccagagatcaagtgtgtggacctgagctgtaatgagctaagtgaagtc
acattaccagaaaacctgcctcccaaactgcaggagctagacctgactggaaacccgcgc
cttgtccttgatcacaaaaccctggaactactgaataatatccgctgtttcaagattgat
cagccttctacaggagacgcttccggagccccagctgtatggagtcatggttacactgaa
gcttcgggggtaaaaaacaagttgtgtgtcgcagccctgtcggtgaataacttctgtgac
aaccgcgaagccctgtatggtgtgtttgacggagaccggaatgtggaggtgccctacctt
ctccagtgcactatgagtgacattttggctgaagagctgcaaaaaacaaaaaacgaagaa
gaatacatggtcaatacattcattgtcatgcaaaggaaacttggaactgctgggcagaag
cttggtggtgccgctgtcctttgtcatatcaagcatgaccctgtggatccaggaggatcc
ttcaccttgacctctgctaatgtgggcaagtgccaaacagttctctgtcgaaatggaaag
ccgctgcctctgtccagatcttacatcatgagctgtgaagaagagctgaagaggattaaa
cagcacaaggccattatcactgaggatggcaaggtgaacggagtgactgagtccacgcgc
atcctgggctacaccttcctccatcccagtgtggtgcctcgcccccacgtgcagtccgtg
ctcctgactccccaggatgagttcttcatcctaggcagtaaggggttgtgggacagcctg
tccgtcgaggaggccgtggaagccgtgcgcaacgtgcccgatgccctggctgctgccaag
aagctgtgtaccctggcccagagctacggctgccacgacagcatcagcgctgtggtggtg
cagctcagtgtcactgaggacagcttctgctgctgcgagctcagcgccggtggggctgtg
ccaccacccagtcctggcatctttcctccctcagtgaacatggtgatcaaggatcggccc
tcagatgggctgggcgtgccgtcctccagcagcggcatggcttccgagattagcagtgag
ctctccacttctgagatgagcagcgaggtggggtcaacagcctccgatgagcccccgccc
ggagccctaagcgagaacagccctgcctaccccagtgagcagcgctgcatgctccacccc
atctgtctgtccaactccttccagcgccagctatccagcgccacgttctctagcgccttc
tccgacaacggccttgacagtgacgatgaggagcccatcgagggcgtcttcaccaacggc
agccgggtggaggtggaggtggacatccactgcagccgggccaaggagaaggagaaacag
cagcacctgcttcaggtgccagcagaggccagtgatgagggcattgtcatcagcgccaac
gaggatgagccaggtctgcccaggaaggcagacttctctgccgttgggaccattgggcgc
cggagggccaatggctctgttgcgccccaggaaaggagccacaatgtgatagaggtggct
acagacgcacctcttcgaaagcctggaggctattttgctgccccggctcagccggatcct
gatgatcagtttatcatacccccggagctggaagaggaggtcaaagaaatcatgaagcat
caccaggagcaacagcagcagcagcagccgccaccaccccctcagctccagccgcagctg
ccgcggcactaccagctggaccagctgccagattattacgacacgccactatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (64)   
   KEGG ORTHOLOGY (1)   
   RefGene (52)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (27)   
   RefSeq(nuc) (1)   
   GenBank (13)   
   EMBL (13)   
Protein domain (5)   
   Pfam (5)   
All databases (106)   

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