KEGG   Homo sapiens (human): 2339
Entry
2339              CDS       T01001                                 
Symbol
FNTA, FPTA, PGGT1A, PTAR2
Name
(RefSeq) farnesyltransferase, CAAX box, subunit alpha
  KO
K05955  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [EC:2.5.1.58 2.5.1.59]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
Drug target
Lonafarnib: D04768<JP/US>
Tipifarnib: D03720
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    2339 (FNTA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    2339 (FNTA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.58  protein farnesyltransferase
     2339 (FNTA)
    2.5.1.59  protein geranylgeranyltransferase type I
     2339 (FNTA)
Prenyltransferases [BR:hsa01006]
 Protein prenylation
  Farnesyltransferase/geranylgeranyltransferase 1
   2339 (FNTA)
SSDB
Motif
Pfam: PPTA
Other DBs
NCBI-GeneID: 2339
NCBI-ProteinID: NP_002018
OMIM: 134635
HGNC: 3782
Ensembl: ENSG00000168522
UniProt: P49354
Structure
Position
8:43056323..43085785
AA seq 379 aa
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDS
PSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLR
DPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQR
YFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHSTENDSPTNVQQ
NT seq 1140 nt   +upstreamnt  +downstreamnt
atggcggccaccgagggggtcggggaggctgcgcaagggggcgagcccgggcagccggcg
caacccccgccccagccgcacccaccgccgccccagcagcagcacaaggaagagatggcg
gccgaggctggggaagccgtggcgtcccccatggacgacgggtttgtgagcctggactcg
ccctcctatgtcctgtacagggacagagcagaatgggctgatatagatccggtgccgcag
aatgatggccccaatcccgtggtccagatcatttatagtgacaaatttagagatgtttat
gattacttccgagctgtcctgcagcgtgatgaaagaagtgaacgagcttttaagctaacc
cgggatgctattgagttaaatgcagccaattatacagtgtggcatttccggagagttctt
ttgaagtcacttcagaaggatctacatgaggaaatgaactacatcactgcaataattgag
gagcagcccaaaaactatcaagtttggcatcataggcgagtattagtggaatggctaaga
gatccatctcaggagcttgaatttattgctgatattcttaatcaggatgcaaagaattat
catgcctggcagcatcgacaatgggttattcaggaatttaaactttgggataatgagctg
cagtatgtggaccaacttctgaaagaggatgtgagaaataactctgtctggaaccaaaga
tacttcgttatttctaacaccactggctacaatgatcgtgctgtattggagagagaagtc
caatacactctggaaatgattaaactagtaccacataatgaaagtgcatggaactatttg
aaagggattttgcaggatcgtggtctttccaaatatcctaatctgttaaatcaattactt
gatttacaaccaagtcatagttccccctacctaattgcctttcttgtggatatctatgaa
gacatgctagaaaatcagtgtgacaataaggaagacattcttaataaagcattagagtta
tgtgaaatcctagctaaagaaaaggacactataagaaaggaatattggagatacattgga
agatcccttcaaagcaaacacagcacagaaaatgactcaccaacaaatgtacagcaataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG ENZYME (2)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (32)   
   RefSeq(nuc) (4)   
   GenBank (14)   
   EMBL (14)   
3D Structure (14)   
   PDB (14)   
Protein domain (1)   
   Pfam (1)   
All databases (79)   

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