KEGG   Homo sapiens (human): 23410
Entry
23410             CDS       T01001                                 
Symbol
SIRT3, SIR2L3
Name
(RefSeq) sirtuin 3
  KO
K11413  NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
hsa05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    23410 (SIRT3)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    23410 (SIRT3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23410 (SIRT3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     23410 (SIRT3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     23410 (SIRT3)
SSDB
Motif
Pfam: SIR2 CutC Rad50_zn_hook
Other DBs
NCBI-GeneID: 23410
NCBI-ProteinID: NP_036371
OMIM: 604481
HGNC: 14931
Ensembl: ENSG00000142082
UniProt: Q9NTG7
Structure
Position
11:complement(215030..236931)
AA seq 399 aa
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
NT seq 1200 nt   +upstreamnt  +downstreamnt
atggcgttctggggttggcgcgccgcggcagccctccggctgtggggccgggtagttgaa
cgggtcgaggccgggggaggcgtggggccgtttcaggcctgcggctgtcggctggtgctt
ggcggcagggacgatgtgagtgcggggctgagaggcagccatggggcccgcggtgagccc
ttggacccggcgcgccccttgcagaggcctcccagacccgaggtgcccagggcattccgg
aggcagccgagggcagcagctcccagtttcttcttttcgagtattaaaggtggaagaagg
tccatatctttttctgtgggtgcttcaagtgttgttggaagtggaggcagcagtgacaag
gggaagctttccctgcaggatgtagctgagctgattcgggccagagcctgccagagggtg
gtggtcatggtgggggccggcatcagcacacccagtggcattccagacttcagatcgccg
gggagtggcctgtacagcaacctccagcagtacgatctcccgtaccccgaggccattttt
gaactcccattcttctttcacaaccccaagccctttttcactttggccaaggagctgtac
cctggaaactacaagcccaacgtcactcactactttctccggctgcttcatgacaagggg
ctgcttctgcggctctacacgcagaacatcgatgggcttgagagagtgtcgggcatccct
gcctcaaagctggttgaagctcatggaacctttgcctctgccacctgcacagtctgccaa
agacccttcccaggggaggacattcgggctgacgtgatggcagacagggttccccgctgc
ccggtctgcaccggcgttgtgaagcccgacattgtgttctttggggagccgctgccccag
aggttcttgctgcatgtggttgatttccccatggcagatctgctgctcatccttgggacc
tccctggaggtggagccttttgccagcttgaccgaggccgtgcggagctcagttccccga
ctgctcatcaaccgggacttggtggggcccttggcttggcatcctcgcagcagggacgtg
gcccagctgggggacgtggttcacggcgtggaaagcctagtggagcttctgggctggaca
gaagagatgcgggaccttgtgcagcgggaaactgggaagcttgatggaccagacaaatag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (26)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (81)   
   RefSeq(nuc) (43)   
   GenBank (19)   
   EMBL (19)   
3D Structure (40)   
   PDB (40)   
Protein domain (3)   
   Pfam (3)   
All databases (185)   

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