KEGG   Homo sapiens (human): 23586
Entry
23586             CDS       T01001                                 
Symbol
RIGI, DDX58, RIG-I, RIG1, RLR-1, SGMRT2
Name
(RefSeq) RNA sensor RIG-I
  KO
K12646  ATP-dependent RNA helicase DDX58 [EC:5.6.2.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05164  Influenza A
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06165  Epstein-Barr virus (EBV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06263  Hepatocellular carcinoma
nt06519  RLR signaling
  Element
N00469  RIG-I-IRF7/3 signaling pathway
N00565  HSV US11 to RIG-I-like receptor signaling pathway
N00688  RIG-I-NFKB signaling pathway
N00727  IAV NS1 to RIG-I-like receptor signaling pathway
N00728  IAV NS1 to RIG-I-like receptor signaling pathway
N01564  Post-translational modifications of RIG-I and MDA5
Disease
H01571  Singleton-Merten syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    23586 (RIGI)
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    23586 (RIGI)
   04623 Cytosolic DNA-sensing pathway
    23586 (RIGI)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    23586 (RIGI)
   05160 Hepatitis C
    23586 (RIGI)
   05171 Coronavirus disease - COVID-19
    23586 (RIGI)
   05164 Influenza A
    23586 (RIGI)
   05162 Measles
    23586 (RIGI)
   05168 Herpes simplex virus 1 infection
    23586 (RIGI)
   05169 Epstein-Barr virus infection
    23586 (RIGI)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    23586 (RIGI)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     23586 (RIGI)
Pattern recognition receptors [BR:hsa04054]
 Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   23586 (RIGI)
SSDB
Motif
Pfam: CARD_2 RIG-I_C RIG-I_C-RD DEAD ResIII Helicase_C AAA_25 Syntaxin_2
Other DBs
NCBI-GeneID: 23586
NCBI-ProteinID: NP_055129
OMIM: 609631
HGNC: 19102
Ensembl: ENSG00000107201
UniProt: O95786
Structure
Position
9:complement(32455302..32526196)
AA seq 925 aa
MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKF
LLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIP
TDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERN
KFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSP
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQI
PVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTI
PSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNT
DEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMR
DTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFL
YTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGI
LTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGN
VIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKI
LHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKE
CFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATG
VQTLYSKWKDFHFEKIPFDPAEMSK
NT seq 2778 nt   +upstreamnt  +downstreamnt
atgaccaccgagcagcgacgcagcctgcaagccttccaggattatatccggaagaccctg
gaccctacctacatcctgagctacatggccccctggtttagggaggaagaggtgcagtat
attcaggctgagaaaaacaacaagggcccaatggaggctgccacactttttctcaagttc
ctgttggagctccaggaggaaggctggttccgtggctttttggatgccctagaccatgca
ggttattctggactttatgaagccattgaaagttgggatttcaaaaaaattgaaaagttg
gaggagtatagattacttttaaaacgtttacaaccagaatttaaaaccagaattatccca
accgatatcatttctgatctgtctgaatgtttaattaatcaggaatgtgaagaaattcta
cagatttgctctactaaggggatgatggcaggtgcagagaaattggtggaatgccttctc
agatcagacaaggaaaactggcccaaaactttgaaacttgctttggagaaagaaaggaac
aagttcagtgaactgtggattgtagagaaaggtataaaagatgttgaaacagaagatctt
gaggataagatggaaacttctgacatacagattttctaccaagaagatccagaatgccag
aatcttagtgagaattcatgtccaccttcagaagtgtctgatacaaacttgtacagccca
tttaaaccaagaaattaccaattagagcttgctttgcctgctatgaaaggaaaaaacaca
ataatatgtgctcctacaggttgtggaaaaacctttgtttcactgcttatatgtgaacat
catcttaaaaaattcccacaaggacaaaaggggaaagttgtcttttttgcgaatcagatc
ccagtgtatgaacagcagaaatctgtattctcaaaatactttgaaagacatgggtataga
gttacaggcatttctggagcaacagctgagaatgtcccagtggaacagattgttgagaac
aatgacatcatcattttaactccacagattcttgtgaacaaccttaaaaagggaacgatt
ccatcactatccatctttactttgatgatatttgatgaatgccacaacactagtaaacaa
cacccgtacaatatgatcatgtttaattatctagatcagaaacttggaggatcttcaggc
ccactgccccaggtcattgggctgactgcctcggttggtgttggggatgccaaaaacaca
gatgaagccttggattatatctgcaagctgtgtgcttctcttgatgcgtcagtgatagca
acagtcaaacacaatctggaggaactggagcaagttgtttataagccccagaagtttttc
aggaaagtggaatcacggattagcgacaaatttaaatacatcatagctcagctgatgagg
gacacagagagtctggcaaagagaatctgcaaagacctcgaaaacttatctcaaattcaa
aatagggaatttggaacacagaaatatgaacaatggattgttacagttcagaaagcatgc
atggtgttccagatgccagacaaagatgaagagagcaggatttgtaaagccctgttttta
tacacttcacatttgcggaaatataatgatgccctcattatcagtgagcatgcacgaatg
aaagatgctctggattacttgaaagacttcttcagcaatgtccgagcagcaggattcgat
gagattgagcaagatcttactcagagatttgaagaaaagctgcaggaactagaaagtgtt
tccagggatcccagcaatgagaatcctaaacttgaagacctctgcttcatcttacaagaa
gagtaccacttaaacccagagacaataacaattctctttgtgaaaaccagagcacttgtg
gacgctttaaaaaattggattgaaggaaatcctaaactcagttttctaaaacctggcata
ttgactggacgtggcaaaacaaatcagaacacaggaatgaccctcccggcacagaagtgt
atattggatgcattcaaagccagtggagatcacaatattctgattgccacctcagttgct
gatgaaggcattgacattgcacagtgcaatcttgtcatcctttatgagtatgtgggcaat
gtcatcaaaatgatccaaaccagaggcagaggaagagcaagaggtagcaagtgcttcctt
ctgactagtaatgctggtgtaattgaaaaagaacaaataaacatgtacaaagaaaaaatg
atgaatgactctattttacgccttcagacatgggacgaagcagtatttagggaaaagatt
ctgcatatacagactcatgaaaaattcatcagagatagtcaagaaaaaccaaaacctgta
cctgataaggaaaataaaaaactgctctgcagaaagtgcaaagccttggcatgttacaca
gctgacgtaagagtgatagaggaatgccattacactgtgcttggagatgcttttaaggaa
tgctttgtgagtagaccacatcccaagccaaagcagttttcaagttttgaaaaaagagca
aagatattctgtgcccgacagaactgcagccatgactggggaatccatgtgaagtacaag
acatttgagattccagttataaaaattgaaagttttgtggtggaggatattgcaactgga
gttcagacactgtactcgaagtggaaggactttcattttgagaagataccatttgatcca
gcagaaatgtccaaatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (15)   
   KEGG NETWORK (15)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (33)   
   RefSeq(nuc) (7)   
   GenBank (13)   
   EMBL (13)   
3D Structure (40)   
   PDB (40)   
Protein domain (8)   
   Pfam (8)   
All databases (143)   

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