KEGG   Homo sapiens (human): 23649
Entry
23649             CDS       T01001                                 
Symbol
POLA2
Name
(RefSeq) DNA polymerase alpha 2, accessory subunit
  KO
K02321  DNA polymerase alpha subunit B
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
Network
nt06509  DNA replication
  Element
N01471  Origin unwinding and elongation
Drug target
Clofarabine: D03546<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    23649 (POLA2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    23649 (POLA2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase alpha / primase complex
    23649 (POLA2)
SSDB
Motif
Pfam: DNA_pol_E_B Pol_alpha_B_N
Other DBs
NCBI-GeneID: 23649
NCBI-ProteinID: NP_002680
OMIM: 620063
HGNC: 30073
Ensembl: ENSG00000014138
UniProt: Q14181
Structure
Position
11:65261962..65305985
AA seq 598 aa
MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSE
ILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGS
QKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGV
SWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAF
TPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQ
VVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPL
LDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHL
VFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHL
GAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLII
PSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI
NT seq 1797 nt   +upstreamnt  +downstreamnt
atgtccgcatccgcccagcagctggcggaggagctgcagatcttcggcctagactgcgag
gaggctctaattgagaaattggtagagctttgtgttcagtatggacagaatgaggaggga
atggtaggcgagcttatagccttctgcaccagcacacataaagttggccttacctcagag
atcctgaactcttttgagcatgagtttctgagcaaaagattatcgaaagccaggcatagt
acctgcaaggacagtggccatgcaggagctagagacattgtttccattcaagagctaatt
gaagtggaagaagaagaggaaatcctcttgaactcttacaccacaccttcaaagggttct
cagaagcgagctatctctaccccagaaacccccctaacaaaaaggagtgtgtcaactcgt
agcccccatcagctactctcaccgtcaagtttctctccaagtgctactccctcccagaaa
tacaactcacgaagtaaccgaggagaagtggttacctccttcggcttagcacagggagta
tcttggtctgggagaggaggagctggaaacatcagcctgaaggtcttgggatgtccagag
gcactaactgggagctacaaatccatgtttcagaagctcccagacattcgagaagttctg
acctgtaagatagaagaacttggcagcgaactcaaggaacattacaagattgaagctttc
actcctttgctagccccagcacaggagcctgtcactctgctgggccagattggctgtgat
agcaacgggaagctgaacaacaagtcagtgattctcgagggagaccgggaacattcctcg
ggtgctcaaattccagtggatttatctgagcttaaggaatattctctgtttcctggacag
gttgtaattatggaaggaatcaacaccactggtaggaaacttgttgccaccaaactctac
gagggtgtgccacttccattttatcagcccactgaagaggatgcagactttgagcaaagc
atggtcctggttgcctgtggaccatacaccacatctgacagcatcacgtatgaccccctg
cttgacctgattgctgtcatcaaccatgaccggccagatgtctgcatcctgtttggccct
ttcctggatgctaagcatgaacaggtggagaattgtctactgacaagtccatttgaagac
attttcaagcagtgtctacgaacaattattgaaggcacaagaagctccggctcccacctt
gtctttgtcccgtcattgagagatgtgcaccatgagcctgtgtacccccagccgcctttc
agctactccgatctgtctcgagaggacaaaaagcaagtacagtttgtgtccgagccctgc
agcctctccataaacggagtgatcttcggcttgacatccacagatctgcttttccacctg
ggggccgaggagatcagtagttcttccggaacttcagacagattcagccgaatactcaag
cacatcttgacccagaggagctactacccactctacccgccccaagaagacatggccatt
gactatgagtcgttctatgtttacgcacagctgcctgtcaccccagatgtcctcatcatc
ccgtcagagctgaggtacttcgtgaaggatgtcctcggctgtgtctgtgtgaaccctggg
cgccttaccaaagggcaggtgggaggcaccttcgcccgactctaccttaggaggccggca
gcggacggggcagagaggcagagcccatgcattgctgtgcaggtcgtcaggatctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (37)   
   RefSeq(nuc) (13)   
   GenBank (12)   
   EMBL (12)   
3D Structure (10)   
   PDB (10)   
Protein domain (2)   
   Pfam (2)   
All databases (91)   

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