KEGG   Homo sapiens (human): 2558
Entry
2558              CDS       T01001                                 
Symbol
GABRA5, DEE79, EIEE79
Name
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha5
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alogabat: D12382
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Cipepofol: D12449
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Darigabat: D12146
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279
Gaboxadol: D04282
Ganaxolone: D04300<US>
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP/US> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP/US> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2558 (GABRA5)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2558 (GABRA5)
   04723 Retrograde endocannabinoid signaling
    2558 (GABRA5)
  09157 Sensory system
   04742 Taste transduction
    2558 (GABRA5)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2558 (GABRA5)
   05033 Nicotine addiction
    2558 (GABRA5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2558 (GABRA5)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2558 (GABRA5)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb CytochromB561_N
Other DBs
NCBI-GeneID: 2558
NCBI-ProteinID: NP_000801
OMIM: 137142
HGNC: 4079
Ensembl: ENSG00000186297
UniProt: P31644
Structure
Position
15:26866719..26949208
AA seq 462 aa
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN
SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
NT seq 1389 nt   +upstreamnt  +downstreamnt
atggacaatggaatgttctctggttttatcatgatcaaaaacctccttctcttttgtatt
tccatgaacttatccagtcactttggcttttcacagatgccaaccagttcagtgaaagat
gagaccaatgacaacatcacgatatttaccaggatcttggatgggctcttggatggctac
gacaacagacttcggcccgggctgggagagcgcatcactcaggtgaggaccgacatctac
gtcaccagcttcggcccggtgtccgacacggaaatggagtacaccatagacgtgtttttc
cgacaaagctggaaagatgaaaggcttcggtttaaggggcccatgcagcgcctccctctc
aacaacctccttgccagcaagatctggaccccagacacgttcttccacaacgggaagaag
tccatcgctcacaacatgaccacgcccaacaagctgctgcggctggaggacgacggcacc
ctgctctacaccatgcgcttgaccatctctgcagagtgccccatgcagcttgaggacttc
ccgatggatgcgcacgcttgccctctgaaatttggcagctatgcgtaccctaattctgaa
gtcgtttacgtctggaccaacggctccaccaagtcggtggtggtggcggaagatggctcc
agactgaaccagtaccacctgatggggcagacggtgggcactgagaacatcagcaccagc
acaggcgaatacacaatcatgacagctcacttccacctgaaaaggaagattggctacttt
gtcatccagacctaccttccctgcataatgaccgtgatcttatcacaggtgtccttttgg
ctgaaccgggaatcagtcccagccaggacagtttttggggtcaccacggtgctgaccatg
acgaccctcagcatcagcgccaggaactctctgcccaaagtggcctacgccaccgccatg
gactggttcatagccgtgtgctatgccttcgtcttctcggcgctgatagagtttgccacg
gtcaattactttaccaagagaggctgggcctgggatggcaaaaaagccttggaagcagcc
aagatcaagaaaaagcgtgaagtcatactaaataagtcaacaaacgcttttacaactggg
aagatgtctcaccccccaaacattccgaaggaacagaccccagcagggacgtcgaataca
acctcagtctcagtaaaaccctctgaagagaagacttctgaaagcaaaaagacttacaac
agtatcagcaaaattgacaaaatgtcccgaatcgtattcccagtcttgttcggcactttc
aacttagtttactgggcaacgtatttgaatagggagccggtgataaaaggagccgcctct
ccaaaataa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (108)   
   KEGG DRUG (108)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (146)   
   RefSeq(nuc) (14)   
   GenBank (66)   
   EMBL (66)   
3D Structure (15)   
   PDB (15)   
Protein domain (3)   
   Pfam (3)   
All databases (308)   

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