KEGG   Homo sapiens (human): 25902
Entry
25902             CDS       T01001                                 
Symbol
MTHFD1L, FTHFSDC1, MTC1THFS, dJ292B18.2
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  KO
K13402  monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:6.3.4.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    25902 (MTHFD1L)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     25902 (MTHFD1L)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 25902
NCBI-ProteinID: NP_056255
OMIM: 611427
HGNC: 21055
Ensembl: ENSG00000120254
UniProt: Q6UB35
Position
6:150865702..151101887
AA seq 978 aa
MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSS
CSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAGDDNLMQEINQNLAE
EAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD
GVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLF
QRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSGKV
GCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP
SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGI
TPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEE
FNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARL
KKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYR
QAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKD
AIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGM
EKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCN
LQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVD
LARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGF
GNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRP
CFYDIDLDTETEQVKGLF
NT seq 2937 nt   +upstreamnt  +downstreamnt
atgggcacgcgtctgccgctcgtcctgcgccagctccgccgcccgccccagcccccgggc
cctccgcgccgcctccgtgtgccctgtcgcgctagcagcggcggcggcggaggcggcggc
ggtggccgggagggcctgcttggacagcggcggccgcaggatggccaggcccggagcagc
tgcagccccggcggccgaacgcccgcggcgcgggactccatcgtcagagaagtcattcag
aattcaaaagaagttctaagtttattgcaagaaaaaaaccctgccttcaagccggttctt
gcaattatccaggcaggtgacgacaacttgatgcaggaaatcaaccagaatttggctgag
gaggctggtctgaacatcactcacatttgcctccctccagatagcagtgaagccgagatt
atagatgaaatcttaaagatcaatgaagataccagagtacatggccttgcccttcagatc
tctgagaacttgtttagcaacaaagtcctcaatgccttgaaaccagaaaaagatgtggat
ggagtaacagacataaacctggggaagctggtgcgaggggatgcccatgaatgttttgtt
tcacctgttgccaaagctgtaattgaacttcttgaaaaatcaggtgtcaacctagatgga
aagaagattttggtagtgggggcccatgggtctttggaagctgctctacaatgcctgttc
cagagaaaagggtccatgacaatgagcatccagtggaaaacacgccagcttcaaagcaag
cttcacgaggctgacattgtggtcctaggctcacctaagccagaagagattccccttact
tggatacaaccaggaactactgttctcaactgctcccatgacttcctgtcagggaaggtt
gggtgtggctctccaagaatacattttggtggactcattgaggaagatgatgtgattctc
cttgctgcagctctgcgaattcagaacatggtcagtagtggaaggagatggcttcgtgaa
cagcagcacaggcggtggagacttcactgcttgaaacttcagcctctctcccctgtgcca
agtgacattgagatttcaagaggacaaactccaaaagctgtggatgtccttgccaaggag
attggattgcttgcagatgaaattgaaatctatggcaaaagcaaagccaaagtacgtttg
tccgtgctagaaaggttaaaggatcaagcagatggaaaatacgtcttagttgctgggatc
acacccacccctcttggagaagggaagagcacagtcaccatcgggcttgtgcaggctctg
accgcacacctgaatgtcaactcctttgcctgcttgaggcagccttcccaaggaccgacg
tttggagtgaaaggaggagccgcgggtggtggatatgcccaggtcatccccatggaggag
ttcaaccttcacttgactggagacatccacgccatcaccgctgccaataacttgctggct
gccgccatcgacacgaggattcttcatgaaaacacgcaaacagataaggctctgtataat
cggctggttcctttagtgaatggtgtcagagaattttcagaaattcagcttgctcggcta
aaaaaactgggaataaataagactgatccgagcacactgacagaagaggaagtgagtaaa
tttgcccgtctcgacatcgacccatctaccatcacgtggcagagagtattggatacaaat
gaccgatttctacgaaaaataaccatcgggcagggaaacacagagaagggccattaccgg
caggcgcagtttgacatcgcagtggccagcgagatcatggcggtgctggccctgacggac
agcctcgcagacatgaaggcacggctgggaaggatggtggtggccagtgacaaaagcggg
cagcctgtgacagcagatgatttgggggtgacaggtgctttgacagttttgatgaaagat
gcaataaaaccaaacctgatgcagaccctggaagggacacctgtgttcgtgcatgcgggc
ccttttgctaacattgctcacggcaactcttcagtgttggctgataaaattgccctgaaa
ctggttggtgaagaaggatttgtagtgaccgaagctggctttggtgctgacatcggaatg
gagaaattcttcaacatcaagtgccgagcttccggcttggtgcccaacgtggttgtgtta
gtggcaacggtgcgagctctgaagatgcatggaggcgggccaagtgtaacggctggtgtt
cctcttaagaaagaatatacagaggagaacatccagctggtggcagacggctgctgtaac
ctccagaagcaaattcagatcactcagctctttggggttcccgttgtggtggctctgaat
gtcttcaagaccgacacccgcgctgagattgacttggtgtgtgagcttgcaaagcgggct
ggtgcctttgatgcagtcccctgctatcactggtccgttggtggaaaaggatcggtggac
ttggctcgggctgtgagagaggctgcgagtaaaagaagccgattccagttcctgtatgat
gttcaggttccaattgtggacaagataaggaccattgctcaggctgtctatggagccaaa
gatattgaactctctcctgaggcacaagccaaaatagatcgttacactcaacagggtttt
ggaaatttgcccatctgcatggcaaagacccacctttctctatctcaccaacctgacaaa
aaaggtgtgccaagggacttcatcttacctatcagtgacgtccgggccagcataggcgct
gggttcatttaccctttggtcggaacgatgagcaccatgccaggactgcccacccggccc
tgcttttatgacatagatcttgataccgaaacagaacaagttaaaggcttgttctaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (60)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (58)   
DNA sequence (102)   
   RefSeq(nuc) (60)   
   GenBank (21)   
   EMBL (21)   
Protein domain (3)   
   Pfam (3)   
All databases (207)   

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