KEGG   Homo sapiens (human): 26035
Entry
26035             CDS       T01001                                 
Symbol
GLCE, HSEPI
Name
(RefSeq) glucuronic acid epimerase
  KO
K01793  heparosan-N-sulfate-glucuronate 5-epimerase [EC:5.1.3.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
hsa01100  Metabolic pathways
Module
hsa_M00059  Glycosaminoglycan biosynthesis, heparan sulfate backbone
Network
nt06029  Glycosaminoglycan biosynthesis
  Element
N01582  Heparan sulfate biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    26035 (GLCE)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.17  heparosan-N-sulfate-glucuronate 5-epimerase
     26035 (GLCE)
SSDB
Motif
Pfam: C5-epim_C Glce_b_sandwich DUF4962
Other DBs
NCBI-GeneID: 26035
NCBI-ProteinID: NP_001311022
OMIM: 612134
HGNC: 17855
Ensembl: ENSG00000138604
UniProt: O94923
Structure
Position
15:69160635..69272207
AA seq 617 aa
MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRRSSSGFRVDGFEKRAAASE
SNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVLGLKYEEIDCLINDEHTIKGR
REGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSKVYAQRAPYHPDGVFMSFEGY
NVEVRDRVKCISGVEGVPLSTQWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAE
DRDKNKPNDWTVPKGCFMANVADKSRFTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKF
LTNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKERDIYYGIGPRTSWSTVTRDLVTDLRK
GVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLDNITISTTAHMAAFFAASDWLVRNQDEKG
GWPIMVTRKLGEGFKSLEPGWYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFL
SEQHGVKAVFMNKHDWYEEYPTTPSSFVLNGFMYSLIGLYDLKETAGEKLGKEARSLYER
GMESLKAMLPLYDTGSGTIYDLRHFMLGIAPNLARWDYHTTHINQLQLLSTIDESPVFKE
FVKRWKSYLKGSRAKHN
NT seq 1854 nt   +upstreamnt  +downstreamnt
atgcgttgcttggcagctcgggtcaactataagactttgattattatctgcgcactcttc
actttggtcacagtacttttgtggaataagtgttccagtgacaaagcaatccagtttcca
cggcgttcgagtagtggcttcagagtggatgggtttgaaaaaagagcagcagcatctgag
agtaacaactatatgaaccacgtggccaaacaacagtctgaggaagcattccctcaggaa
cagcagaaagcaccccctgttgttgggggcttcaatagcaatgtgggaagtaaggtgtta
gggctcaaatatgaagaaattgactgtctcataaatgatgaacacacaattaaagggaga
cgagaggggaacgaagtctttcttccattcacttgggttgagaaatattttgatgtttat
ggaaaggtggttcagtatgatggctatgatcggtttgaattctctcatagctattccaaa
gtctatgcacagagagccccctatcaccccgatggtgtgtttatgtcttttgaaggctac
aatgtggaagtccgagacagagtcaagtgcataagtggggttgaaggtgtgccattatct
acacaatggggacctcaaggctatttctatccaatccagattgcacagtatggattaagt
cattacagcaagaatctaactgagaaacctcctcacatagaggtatatgaaacagcagaa
gacagagacaaaaacaagcctaatgactggactgtgccaaagggctgctttatggcgaat
gtggctgataagtctagattcaccaatgtcaaacagtttattgcaccagaaaccagtgaa
ggtgtatccttgcaactgggaaacacaaaagattttattatttcatttgacctcaagttc
ttgacaaatggaagtgtgtccgtggttctagagaccacagaaaagaatcagctcttcact
atacattatgtctcaaatgctcagctaattgcttttaaagaaagagatatatactatggc
attgggcccagaacttcatggagcacagttaccagggacctggtcactgacctcaggaaa
ggagtgggtctttcaaacacaaaagctgtcaagccaaccaaaataatgcccaagaaggtg
gttaggttgattgcaaaaggtaagggattcctcgacaacattaccatctctaccacagcc
cacatggctgcattttttgctgctagtgattggctagtaaggaaccaggatgagaaaggt
ggctggccaattatggtgacccgtaagttaggggaagggttcaagtctttagagccagga
tggtattctgccatggcccaagggcaagccatttctacattagtcagggcctatctgtta
acaaaagaccatatattcctcaattcagctttaagggcaacagccccttataagtttcta
tctgagcagcatggagttaaagctgtgtttatgaataaacatgactggtatgaagaatat
ccaaccacacctagctcttttgttttaaatggctttatgtattctttaattgggctgtat
gacttaaaagaaactgcaggggaaaaactcggaaaagaagcaaggtccttgtatgagcgt
ggcatggaatctcttaaagccatgctgcccttgtatgacactggctcaggaaccatctat
gacctccgtcacttcatgcttggcatcgctcctaacctggctcgctgggactatcatacc
acccacatcaatcagttgcagctactcagtaccattgatgagtccccagtcttcaaagaa
tttgtcaagaggtggaaaagctaccttaaaggcagcagggcaaagcacaactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (31)   
   RefSeq(nuc) (17)   
   GenBank (7)   
   EMBL (7)   
3D Structure (3)   
   PDB (3)   
Protein domain (3)   
   Pfam (3)   
All databases (80)   

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