KEGG   Homo sapiens (human): 26191
Entry
26191             CDS       T01001                                 
Symbol
PTPN22, LYP, LYP1, LYP2, PEP, PTPN22.5, PTPN22.6, PTPN8
Name
(RefSeq) protein tyrosine phosphatase non-receptor type 22
  KO
K18024  tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Disease
H00080  Systemic lupus erythematosus
H00408  Type 1 diabetes mellitus
H00630  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    26191 (PTPN22)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     26191 (PTPN22)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    26191 (PTPN22)
SSDB
Motif
Pfam: Y_phosphatase Y_phosphatase3 DSPc
Other DBs
NCBI-GeneID: 26191
NCBI-ProteinID: NP_057051
OMIM: 600716
HGNC: 9652
Ensembl: ENSG00000134242
UniProt: Q9Y2R2 B4DZW8
Structure
Position
1:complement(113813811..113871759)
AA seq 807 aa
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY
KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS
ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE
ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL
LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC
FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW
PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES
AVLATAPRIDDEIPPPLPVWTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS
EPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIET
YSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNS
SSFLNFGFANRFSKPKGPRNPPPTWNI
NT seq 2424 nt   +upstreamnt  +downstreamnt
atggaccaaagagaaattctgcagaagttcctggatgaggcccaaagcaagaaaattact
aaagaggagtttgccaatgaatttctgaagctgaaaaggcaatctaccaagtacaaggca
gacaaaacctatcctacaactgtggctgagaagcccaagaatatcaagaaaaacagatat
aaggatattttgccctatgattatagccgggtagaactatccctgataacctctgatgag
gattccagctacatcaatgccaacttcattaagggagtttatggacccaaggcttatatt
gccacccagggtcctttatctacaaccctcctggacttctggaggatgatttgggaatat
agtgtccttatcattgttatggcatgcatggagtatgaaatgggaaagaaaaagtgtgag
cgctactgggctgagccaggagagatgcagctggaatttggccctttctctgtatcctgt
gaagctgaaaaaaggaaatctgattatataatcaggactctaaaagttaagttcaatagt
gaaactcgaactatctaccagtttcattacaagaattggccagaccatgatgtaccttca
tctatagaccctattcttgagctcatctgggatgtacgttgttaccaagaggatgacagt
gttcccatatgcattcactgcagtgctggctgtggaaggactggtgttatttgtgctatt
gattatacatggatgttgctaaaagatgggataattcctgagaacttcagtgttttcagt
ttgatccgggaaatgcggacacagaggccttcattagttcaaacgcaggaacaatatgaa
ctggtctacaatgctgtattagaactatttaagagacagatggatgttatcagagataaa
cattctggaacagagagtcaagcaaagcattgtattcctgagaaaaatcacactctccaa
gcagactcttattctcctaatttaccaaaaagtaccacaaaagcagcaaaaatgatgaac
caacaaaggacaaaaatggaaatcaaagaatcttcttcctttgactttaggacttctgaa
ataagtgcaaaagaagagctagttttgcaccctgctaaatcaagcacttcttttgacttt
ctggagctaaattacagttttgacaaaaatgctgacacaaccatgaaatggcagacaaag
gcatttccaatagttggggagcctcttcagaagcatcaaagtttggatttgggctctctt
ttgtttgagggatgttctaattctaaacctgtaaatgcagcaggaagatattttaattca
aaggtgccaataacacggaccaaatcaactccttttgaattgatacagcagagagaaacc
aaggaggtggacagcaaggaaaacttttcttatttggaatctcaaccacatgattcttgt
tttgtagagatgcaggctcaaaaagtaatgcatgtttcttcagcagaactgaattattca
ctgccatatgactctaaacaccaaatacgtaatgcctctaatgtaaagcaccatgactct
agtgctcttggtgtatattcttacatacctttagtggaaaatccttatttttcatcatgg
cctccaagtggtaccagttctaagatgtctcttgatttacctgagaagcaagatggaact
gtttttccttcttctctgttgccaacatcctctacatccctcttctcttattacaattca
catgattctttatcactgaattctccaaccaatatttcctcactattgaaccaggagtca
gctgtactagcaactgctccaaggatagatgatgaaatcccccctccacttcctgtatgg
acacctgaatcatttattgtggttgaggaagctggagaattctcaccaaatgttcccaaa
tccttatcctcagctgtgaaggtaaaaattggaacatcactggaatggggtggaacatct
gaaccaaagaaatttgatgactctgtgatacttagaccaagcaagagtgtaaaactccga
agtcctaaatcagaactacatcaagatcgttcttctcccccacctcctctcccagaaaga
actctagagtccttctttcttgccgatgaagattgtatgcaggcccaatctatagaaaca
tattctactagctatcctgacaccatggaaaattcaacatcttcaaaacagacactgaag
actcctggaaaaagtttcacaaggagtaagagtttgaaaattttgcgaaacatgaaaaag
agtatctgtaattcttgcccaccaaacaagcctgcagaatctgttcagtcaaataactcc
agctcatttctgaattttggttttgcaaaccgtttttcaaaacccaaaggaccaaggaat
ccaccaccaacttggaatatttaa

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Ontology (3)   
   KEGG BRITE (3)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (25)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (22)   
DNA sequence (58)   
   RefSeq(nuc) (22)   
   GenBank (18)   
   EMBL (18)   
3D Structure (9)   
   PDB (9)   
Protein domain (3)   
   Pfam (3)   
All databases (125)   

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